In this work, we present a simple complementary metal-oxide semiconductor (CMOS)-controlled photovoltaic power-transfer platform that is suitable for very small (less than or equal to 1–2 mm) electronic devices such as implantable health-care distributed nodes the Internet of Things. We designed 1.25 mm × CMOS power receiver chip contains integrated cells. characterized CMOS-integrated and successfully demonstrated blue light-emitting diode (LED) operation powered by infrared light. Then,...

We report a lens-free fluorescence imaging device using composite filter composed of an interference and absorption filter, each applied to one side fiber optic plate (FOP). The transmission angled excitation light through the is absorbed by filter. auto-fluorescence reduced reflection from normally incident light. As result, high-performance rejection achieved in device. FOP provides flat, hard surface that does not degrade spatial resolution. demonstrate approximately 108:1 at wavelength...

In this review, we present an implantable microimaging device to observe brain activities of small experimental animals such as mice and rats. Three categories devices are described: optical fiber system, a head-mountable fluorescent microscope, ultrasmall image sensor that can be directly implanted into the brain. Among them, focus on third one, because is powerful tool explore in deep region freely moving mouse. The structure performance shown with some examples images mice.

Abstract To advance the practical application of retinal prostheses with high spatial resolution through parallel stimulation, we developed a dynamic power supply voltage control system designed to enable stable constant-current stimulation in vivo, regardless number active points. The proposed prosthesis integrates CMOS chip, containing current sources and electrode selection circuits, into array implanted eye. This configuration facilitates individual over 1000 electrodes minimal wiring....

This paper introduces an image processing method, used to achieve uniform sensitivity across the imaging plane in a high-frequency electric field system, that employs electro-optical crystal and polarization sensor. The pixels have two directions, 0° 90°, pairs, and, conventionally, their difference is computed first. In contrast, this study proposes method separate each image, perform pixel completion, subsequently intensity correction. proposed was demonstrated improve distribution images...

An observation technique for animal brain activity under freely moving conditions is important to understand functions because an anesthetized condition different from that a nonanesthetized condition. We have developed ultrasmall CMOS imaging device conditions. This composed of image sensor chip and nine LEDs illumination. It weighs only 0.02 g its small size enables experiments be performed without restricting movement. feature advantageous imaging, particularly in situations. In this...

In this paper, we propose and demonstrate an implantable CMOS image sensor with self-resetting pixels. The function is implemented using a four-transistor Schmitt trigger inverter. pixel has no counter for the number of self-resets, because application does not require radiometric (linear) response. fabricated 0.35-μm 2-poly 4-metal standard technology, which results in size 15 μm×15 μm fill factor 31%. effective peak signal-to-noise ratio >59 dB. An prototype comprising 60 × 134 array...

In this article, We demonstrated an image sensor for detecting changes in polarization with high sensitivity.For purpose, we constructed optical system a two-layer structure, comprising external polarizer and polarizers on pixel array.An is used to enhance the rotation while reducing intensity avoid saturation of sensor.Using two can be arranged under optimal conditions achieve polarization-change detection performance.We fabricated using 0.35-µm CMOS process and, by averaging 50 × pixels 96...

In this research, we combined our ultralight micro-imaging device for calcium imaging with microdialysis to simultaneously visualize neural activity in the dorsal raphe nucleus (DRN) and measure serotonin release central of amygdala (CeA) anterior cingulate cortex (ACC). Using platform, observed brain following nociception induced by formalin injection mouse's hind paw. Our showed that DRN fluorescence intensity increased after injection, increase was highly correlated elevation both CeA...

The application of the fluorescence imaging method to living animals, together with use genetically engineered animals and synthesized photo-responsive compounds, is a powerful for investigating brain functions.Here, we report surface deep tissue that uses compact mass-producible semiconductor devices based on complementary metal-oxide (CMOS) technology.An image sensor chip was designed be inserted into tissue, its size 1500 × 450 μm.Sample illumination also key issue intravital...

Abstract To better understand the brain function based on neural activity, a minimally invasive analysis technology in freely moving animal is necessary. Such would provide new knowledge neuroscience and contribute to regenerative medical techniques prosthetics care. An application that combines optogenetics for voluntarily stimulating nerves, imaging visualize activity wearable micro-instrument implantation into could meet abovementioned demand. this end, micro-device can be applied less...

Abstract A self-reset pixel of 15 × µm 2 with high signal-to-noise ratio (effective peak SNR ≃64 dB) for an implantable image sensor has been developed intrinsic signal detection arising from hemodynamic responses in a living mouse brain. For detecting local conversion between oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) brain tissues, imaging device was fabricated our newly designed orange light-emitting diodes (LEDs; λ = 605 nm). We demonstrated the sensory cortical area accompanied by...

We demonstrate a highly sensitive lensless fluorescence imaging device with wide field-of-view by using hybrid bandpass filter composed of interference filters, an absorption filter, and fiber optic plate. The shows high excitation light rejection characteristics even in setup. In this study, we fabricated improved observation performance for target auto-fluorescence. was combined large image sensor area 67 mm2. As demonstration, brain slice from green fluorescent protein transgenic mouse...

Abstract In this paper, we propose an improved on-pixel polarizer structure for image sensor, which was fabricated using the 0.35 μ m standard CMOS process with dual metal layers (Metal 1 and Metal 2), i.e. two of gratings metal-wiring were stacked. By designing line/space ratio as 0.7/0.7 m, extinction significantly at a wavelength 780 nm, over 1.4 times higher than that single-layer grating, detection sensitivity polarization change enhanced by more 1.8 times. We also demonstrated...

Although fluorescence microscopy is the gold standard tool for biomedical research and clinical applications, their use beyond well-established laboratory infrastructures remains limited. The present study investigated a novel on-chip cell analysis platform based on contact microfluidics. Combined of imager complementary metal-oxide semiconductor technology an ultra-thin glass bottom microfluidic chip enabled both to observe living cells with minimal image distortion ease controlling...

Abstract The autofluorescence of mitochondrial flavoprotein is very useful for functional brain imaging because the fluorescence intensity changes as per neural activities. In this study, we developed an implantable device green and detected associated with visual stimulation using device. We examined performance anesthetized mice. set on cortex measured in response to stimulation. A full-field sinusoidal grating a vertical orientation was used applying activate cortex. successfully observed...

This paper presents an implantable fluorescence system with a composite emission filter and fiber-coupled laser excitation.The structure of the short-pass interference absorption filters exhibited band-pass spectrum between 510 570 nm, which is close to green fluorescent protein (GFP) emission.A high-quality excitation light was achieved by utilizing blue through low-numerical-aperture optical fiber.This coupling method beneficial in delivering narrow controllable irradiation specific area...

Wireless epidermal wearable devices attract interests and expectations as a tool for personalized, low-cost health monitoring technology. The concept of the wireless attachable personal has been more widely considered by combining them with biosensors. To bring most advantage out structure device, battery-free approach was introduced to reduce volume extend lifetime device. In this work, an energy harvesting technology noninvasive sensor were applied power system painless measuring system. A...

Dopamine (DA) is the key regulator of reward behavior. The DA neurons in ventral tegmental area (VTA) and their projection areas, which include prefrontal cortex (PFC), nucleus accumbens (NAc), amygdala, play a primary role process reward-driven behavior induced by drugs addiction, including nicotine alcohol. In our previous study, we developed novel platform consisting micro-LED array devices to stimulate large brain rats monkeys with photo-stimulation microdialysis probe estimate release...

A brain functional imaging technique over a long period is important to understand functions related animal behavior. We have developed small implantable CMOS device for measuring activity in freely moving animals. This composed of image sensor chip and LEDs illumination. In this study, we demonstrated intrinsic signal blood flow using the with green LED light source at peak wavelength 535 nm, which corresponds one absorption spectral peaks cells. Brain increases regional flow. The weight...

Angle-selective pixels fabricated by using metal layers of the image sensor chip are proposed. Four incident-angle-selective share one aperture. The selective pixel has a peak at 40° and full width half maximum ∼23°. An composed normal angle-sensitive was designed fabricated. reconstruction high-resolution from blurred five different views is demonstrated.

Optogenetics is a powerful tool for controlling biological functions using light. Optical fibers have been extensively utilized in optical stimulation devices optogenetics. However, the use of results small photo-stimulation region. In this study, micro-LED array were developed to achieve large-area brain large animal, such as macaque monkeys. Planar and linear designed fabricated photo-stimulate prefrontal cortex (PFC) ventral tegmental area (VTA) induce neurochemical response. Device...