A5079989633- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Cancer Cells and Metastasis
- Multiple and Secondary Primary Cancers
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Angiogenesis and VEGF in Cancer
- Anorectal Disease Treatments and Outcomes
- Lung Cancer Research Studies
Osaka Rosai Hospital
2019-2025
Osaka University
2003-2024
Kindai University
2013-2023
Saiseikaisenri Hospital
2023
Osaka National Hospital
2006-2018
Kawasaki Medical School
2017
Roswell Park Comprehensive Cancer Center
2006-2014
Abstract Pancreatic cancer is the most lethal of all solid tumors partially because its chemoresistance. Although gemcitabine widely used as a first selected agent for treatment this disease despite low response rate, molecular mechanisms resistance in pancreatic still remain obscure. The aim study to elucidate resistance. 81‐fold resistant variant MiaPaCa2‐RG was from cell line MiaPaCa2. By microarray analysis between MiaPaCa2 and MiaPaCa2‐RG, 43 genes (0.04%) were altered expression more...
The expression of the Wilms' tumor gene WT1 was examined by immunohistochemistry in 40 cases pancreatic ductal adenocarcinoma. protein expressed 30 (75%) adenocarcinomas, but not remaining 10 (25%). In normal cells, undetectable. No correlations between and clinicopathological parameters such as age, sex, T or N stage, location, differentiation were observed. Treatment with anti‐sense oligomers significantly inhibited growth five human cancer cell lines, PSN1, MiaPaCa2, ASPC1, BxPC3, PCI6,...
Abstract Anti‐metastatic activity of an antitumor agent is exceedingly important because metastasis the primary cause death for most solid cancer patients. In this report, we show that 3 anti‐endoglin (ENG) monoclonal antibodies (mAbs) SN6a, SN6j and SN6k which define individually distinct epitopes ENG tumor vasculature are capable suppressing metastases in multiple models. The models were generated by i.v., s.c. (into flank) or mammary gland fat pad injection 4T1 murine carcinoma cells...
Pancreatic mucinous cystic neoplasm (MCN) is a tumor of the pancreas typically located in pancreatic body or tail middle-aged women. However, MCN rupture rare. This report describes case with spontaneous during follow-up. The patient was 34-year-old woman. Contrast-enhanced computed tomography (CECT) and magnetic resonance imaging (MRI) revealed 130 mm multifocal cyst tail. cyst, characterized by multiple septa cyst-in-cyst structures, diagnosed as an MCN. Initially, opted for periodic...
Desmoplastic small round cell tumor (DSRCT) is a highly malignant sarcoma and an extremely rare tumor, predominantly found in the abdominal pelvic regions. Here, we report case of patient who underwent surgical treatment for multiple desmoplastic intestine. A 38-year-old male visited our hospital after health check revealed positive occult blood his stool colonoscopy tumors descending colon sigmoid colon. Biopsy results poorly differentiated adenocarcinoma. Chest enhanced computed tomography...
Granulomatous mastitis (GM) is a rare chronic inflammatory breast condition with unknown etiology. There still no generally accepted optimal treatment for GM. Corticosteroid and/or wide excision most commonly reported in the literature. Incision and drainage or limited alone has little benefit because of strong tendency recurrence. Corticosteroids also have high failure rate possible side effects. In current series, we treated GM patients without corticosteroids, except one patient. We...
Abstract In the present study, we investigated mechanisms by which anti‐endoglin (EDG; CD105) monoclonal antibodies (mAbs) suppress angiogenesis and tumor growth. Antihuman EDG mAb SN6j specifically bound to murine endothelial cells was internalized into in vitro . effectively suppressed mice Matrigel plug assay. We found that is more effective for suppression immunocompetent than SCID mice. hypothesized T cell immunity important antitumor efficacy of vivo To test this hypothesis, effects...
AIMTo evaluate clinicopathological features and surgical outcomes of gastric cancer in elderly non-elderly patients after inverse probability treatment weighting (IPTW) method using propensity score.June 15, 2017|Volume 9|Issue 6| WJGO|www.wjgnet.comFujiwara Y et al .Age post-gastrectomy morbidity/mortality independent prognostic values for OS. CONCLUSIONWhen the gastrectomy was performed patients, we should recognized high mortality comorbidities that elderly.More extensive lymph node...
Abstract Background The optimal neoadjuvant chemotherapy (NAC) regimen for patients with localized pancreatic ductal adenocarcinoma (PDAC) remains uncertain. This trial aimed to evaluate the efficacy and safety of two regimens, gemcitabine plus nab-paclitaxel (GA) S-1 (GS), in resectable/borderline-resectable (R/BR) PDAC. Patients Methods Treatment-naïve R/BR-PDAC were enrolled randomly allocated. They received cycles (2 months) each standard protocol, followed by radical surgery those...
To reveal the implication in gastric cancer pathogenesis of novel human gene referred to as CA11, which was recently isolated by a differential display technique using normal mucosa and tissue, we examined CA11 expression 50 primary cancers also introduced into cells. RNA dot blot analysis against various organs developmental stages demonstrated that intensively expressed especially stomach tissue. Northern showed tissue down-regulated compared with Semi-quantitative RT-PCR decreased 41 out...
Anaplastic thyroid carcinoma is an aggressive neoplasm and resistant to all sorts of treatment due its rapid growth invasive potential. Peroxisome proliferator-activated receptor gamma (PPARgamma) a nuclear modulating variety biological properties, such as regulating adipogenesis, inhibition cancer cell proliferation or differentiation tumor cells. The purpose this study was evaluate the possibility for therapeutic effect PPARgamma ligands against anaplastic in vitro. Expressions PPARc gene...
We investigated anti-angiogenic/vascular targeting therapy of established tumors in immunocompetent mice using an anti-human endoglin (EDG; CD105) monoclonal antibody (mAb) SN6j. SN6j weakly cross-reacted with murine endothelial cells but reacted neither colon-26 colon carcinoma nor 4T1 mammary cells. Systemic administration naked (unconjugated) showed significant growth suppression and BALB/c (P<0.05). Moreover, the overall survival rate SN6j-treated was significantly higher than that...
To compare the usefulness of self-expanding metallic stent (SEMS) with that transanal drainage tube (TDT) and emergency surgery after failure decompression (ESFD) in patients malignant colonic obstruction (MCO), to evaluate post-decompression histopathologic changes.From January 2010 June 2015, 39 MCO received SEMS, TDT, ESFD. We evaluated outcomes including success rates placement, clinical decompression, findings resected specimens.Technical were 100% for SEMS 78.9% TDT. Clinical 80.0%...
Uridine diphosphate (UDP) N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl transferase 3 (GalNAc-T3), one of the enzymes that catalyze initial glycosylation mucin type O-linked proteins, was shown to associate with differentiation cancer cell lines and prognosis some kinds cancers. In present study, association GalNAc-T3 expression clinicopathologic features pancreatic adenocarcinoma patients' survival examined. The level analyzed immunohistochemically in paraffin-embedded...
Disseminated carcinomatosis of the bone marrow (DCBM) is a condition in which (BM) metastases diffusely invade BM, and frequently accompanied by disseminated intravascular coagulation (DIC). While prostate, lung, breast stomach malignancies, addition to neuroblastoma, are most prevalent non-hematological malignancies metastasize colorectal cancer malignancy that rarely metastasizes BM. The present case describes 65-year-old male patient treated resection one course adjuvant chemotherapy for...