A5073926001- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- HER2/EGFR in Cancer Research
- Nutrition and Health in Aging
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Gastrointestinal disorders and treatments
- Multiple and Secondary Primary Cancers
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Enhanced Recovery After Surgery
- Complement system in diseases
- Colorectal Cancer Surgical Treatments
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Robotics and Sensor-Based Localization
Osaka Prefectural Medical Center
2012-2025
Osaka Police Hospital
2023-2025
Osaka International Cancer Institute
2022-2025
Sakai Municipal Hospital
2021-2024
Osaka National Hospital
2015-2024
Osaka International University
2024
Ebara (Japan)
2022-2024
Kyushu University
2004-2024
Oita University
2023
Kindai University
2023
This study evaluated the continuous use of trastuzumab beyond progression (TBP) in human epidermal growth factor receptor 2 (HER2)-positive advanced gastric or gastroesophageal junction (G/GEJ) cancer.Patients with HER2-positive G/GEJ cancer refractory to first-line chemotherapy combination fluoropyrimidine and platinum were eligible. Patients randomly assigned paclitaxel (80 mg/m2, days 1, 8, 15, every 4 weeks) (PT; initially 8 mg/kg followed by 6 mg/kg, 3 arms. The primary endpoint was...
In patients with glomerulonephritis widespread crescents are associated a poor prognosis. Crescent formation appears to depend on the migration of mononuclear cells into Bowman's space, and therefore interaction between leukocytes glomerular endothelium may be critical event in genesis crescents. We performed present study determine effects mouse monoclonal antibodies adhesion molecules intercellular molecule 1 (ICAM-1) lymphocyte function-associated antigen (LFA-1) model crescentic...
Human epidermal growth factor (HER) 2 positivity and its association with clinicopathological factors remain unclear in Japanese gastric cancer (GC) patients. We performed a prospective, multicenter, observational cohort study to evaluate HER2 protein expression gene amplification metastatic recurrent GC patients, explored correlations features.HER2 were centrally assessed formalin-fixed, paraffin-embedded tissue by immunohistochemistry (IHC) fluorescence situ hybridization (FISH). Patient...
Abstract Purpose We propose a deep learning-based image interpretation system for skeleton segmentation and extraction of hot spots bone metastatic lesion from whole-body scintigram followed by automated measurement scan index (BSI), which will be clinically useful. Methods The proposed employs butterfly-type networks (BtrflyNets) lesions, in pair anterior posterior images are processed simultaneously. BSI is then measured using the segmented bones extracted spots. To further improve...
Abstract Background The increasing incidence of gastric cancer in the elderly underscores need for an in-depth understanding challenges and risks associated with surgical interventions this demographic. This study aims to investigate risk factors prognostic indicators non-cancer-related mortality following curative surgery patients. Methods retrospective analysis examined 684 patients pathological Stage I—III who underwent resection between January 2012 December 2021. focused on aged 70...
AimThe optimal second-line regimen for treating advanced gastric cancer (AGC) remains unclear. While irinotecan (CPT-11) plus cisplatin (CDDP) combination therapy and CPT-11 monotherapy have been explored in the setting, superiority of platinum-based therapies AGC patients initially treated with S-1 has not yet evaluated; therefore, we aimed to examine survival benefit CPT-11/CDDP over monotherapy.MethodsAGC showing progression after or recurrence within 6 months completion adjuvant were...
Abstract Background In the ABSOLUTE trial, weekly nanoparticle albumin-bound paclitaxel (w-nab-PTX) showed non-inferiority to solvent-based (w-sb-PTX) for overall survival (OS). Thus, w-nab-PTX might be an option second-line chemotherapy in advanced gastric cancer (AGC). However, predictive factors efficacies of these agents have not been evaluated. Methods Patients previously enrolled trial were divided into apparent peritoneal metastasis group (PM group) and no (no PM based on baseline...
Lentinan (LNT) is a purified β-1, 3-glucan that augments immune responses. The present study was conducted to assess the efficacy of LNT in combination with S-1 as first-line treatment for unresectable or recurrent gastric cancer.Eligible patients were randomly assigned receive alone plus LNT. primary end-point overall survival (OS). Secondary end-points time-to-treatment failure (TTF), response rate (ORR), safety, quality life (QOL), and biomarker. percentages LNT-binding monocytes...