A5061109504- Parathyroid Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Renal and related cancers
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Thermal Regulation in Medicine
- Ion Transport and Channel Regulation
- Hormonal Regulation and Hypertension
- Heart Failure Treatment and Management
- Nutrition and Health in Aging
- Anesthesia and Pain Management
- Multiple and Secondary Primary Cancers
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Biomedical Text Mining and Ontologies
- Colorectal and Anal Carcinomas
- Advanced Breast Cancer Therapies
- Pregnancy and preeclampsia studies
- Medical Imaging and Pathology Studies
- Neutropenia and Cancer Infections
- Renin-Angiotensin System Studies
- Chronic Lymphocytic Leukemia Research
- Chemotherapy-induced organ toxicity mitigation
Osaka International Cancer Institute
2019-2024
Toyama City Hospital
2019
Japan Community Healthcare Organization
2017
Chukyo Hospital
2017
Gifu Red Cross Hospital
2017
Osaka Prefectural Medical Center
2008-2016
Osaka City General Hospital
2014-2016
Nagoya University
1999-2014
Sapporo Medical University
2014
Toyama University Hospital
2014
To investigate the clinical, genetic, and neuroradiologic presentations of idiopathic basal ganglia calcification (IBGC) in a nationwide study Japan.We documented clinical neuroimaging data total 69 subjects including 23 from 10 families 46 sporadic cases IBGC Japan. Mutational analysis SLC20A2 was performed.Six new mutations were found patients with IBGC: 4 missense mutations, 1 nonsense mutation, frameshift mutation. Four them familial 2 our survey. The frequency Japan 50%, which as high...
Abstract Background and Aim To investigate the outcomes in eight Japanese patients with cancer treated mycophenolate mofetil (MMF) corticosteroids for immune checkpoint inhibitor treatment‐induced severe immune‐related hepatitis (ir‐hepatitis) efficacy safety of MMF. Methods We retrospectively examined patient background, treatment course, as well examination imaging data using electronic medical records. Results The ratio male to female was 7:1, median age 60 years (27–72 years). There were...
The present study investigated outcomes of infliximab (IFX) treatment among 8 Japanese patients with various types cancer (4 malignant melanoma, 3 lung and 1 renal cancer) who developed severe steroid‑resistant immune‑related adverse events (irAEs) in association immune checkpoint inhibitors (ICIs) to determine its efficacy safety. Information, including patient background, progress, examination data imaging data, was collected retrospectively from electronic medical records. Adverse...
The effect of atrial natriuretic peptide (ANP) on renin release is controversial. Several reports state that ANP inhibits secretion, while others have shown no effect. We investigated the synthetic rat with 24 amino acids (atriopeptin III) in vitro a dynamic superfusion system renal cortical slices as well collagenase-dispersed juxtaglomerular cells. In kidney slices, isoproterenol (5 × 10-8 M) clearly stimulated from angiotensin II (All; 10-5 suppressed release. (10-10-10-6 did not inhibit...
The most recommended treatment for stage IV EGFR-positive lung cancer is osimertinib monotherapy. dosage of fixed at 80 mg/day regardless body surface area (BSA), however some patients withdraw or reduce the due to adverse events (AEs). We performed a retrospective cohort study 98 with EGFR mutation-positive non-small cell (NSCLC), who received mg as initial treatment. investigated impact BSA on efficacy and safety osimertinib. cut-off value was estimated using receiver operating...
Adverse Drug Events (ADE) are key information present in unstructured portions of Electronic Health Records. These pose a significant challenge healthcare, ranging from mild discomfort to severe complications, and can impact patient safety treatment outcomes.
The current study reports comparing the postoperative mechanical properties of anterior capsule between femtosecond laser capsulotomy (FLC) and continuous curvilinear capsulorhexis (CCC) variable size shape in porcine eyes. All CCCs were created using forceps. Irregular or eccentric also to simulate real cataract surgery. For FLC, capsulotomies 5.3 mm diameter LenSx® (Alcon) platform. Fresh eyes used all experiments. edges openings pulled at a constant speed two L-shaped jigs. Stretch force...
Chemotherapy is among the standard treatments for esophageal cancer. The docetaxel, 5-fluorouracil, and cisplatin (DCF) protocol yields a better response rate than 5-fluorouracil plus cisplatin. However, incidence of side effects, such as febrile neutropenia hematologic toxicity, also significantly high with DCF protocol. granulocyte colony-stimulating factor pegfilgrastim are prophylactically administered to prevent neutropenia. This retrospective study evaluated efficacy safety in patients...
Summary: Atrial natriuretic factor (ANF) inhibits basal and stimulated aldosterone production in vitro vivo. Infusions of ANF have been reported to inhibit renin release several species, including humans. A 4-h infusion into 12 patients with mild hypertension reduced plasma at 2 4 h, a rebound increase h after the end infusion. Plasma activity also showed but significant reduction 6 h. The effect on is controversial. Using superfusion system rat renal cortical slices dispersed...
Atrial natriuretic factor (ANF) inhibits basal and stimulated aldosterone production in vitro vivo. Infusions of ANF have been reported to inhibit renin release several species, including humans. A 4-h infusion into 12 patients with mild hypertension reduced plasma at 2 4 h, a rebound increase h after the end infusion. Plasma activity also showed but significant reduction 6 h. The effect on is controversial. Using superfusion system rat renal cortical slices dispersed juxtaglomerular (JG)...
Purpose: To evaluate the color visual acuity (CVA) of young healthy subjects using colored Landolt rings and effect background luminance level on CVA.Materials methods: We measured CVA 20 (age: 23.8 ± 3.8 years) with different colors a computer liquid crystal display, 15 ring (30 cd/m2) 30 cd/m2, then 100 cd/m2. used levels (15–50 four (red, green–yellow, green, blue–green) to CVA.Results: The significantly differed among cd/m2 (p < 0.0001). Green–yellow blue–purple had poor (high LogMAR...
Abstract Purpose To compare the self‐sealing features and dimensional stability between femtosecond laser ( FL ) manual knife corneal incision. Methods For clinical study, 29 consecutive eyes from patients 28 who underwent cataract surgery with incision incision, respectively, were enrolled. Immediately after surgery, of incisions evaluated. Scanning electron microscopy SEM images obtained. experimental clear a or different energy settings (3, 6 9 μ J) created in fresh porcine eyes, followed...
Abstract Background Nanoliposomal irinotecan (nal-IRI) plus 5-fluorouracil (5-FU)/ levo -leucovorin ( Levo -LV) was approved for unresectable pancreatic cancer (UR-PC) in March 2020 Japan. -LV is administered by intravenous infusion over 120 min following 90 of nal-IRI (conventional method), causing a significant burden on both patients and the outpatient chemotherapy room owing to prolonged administration time. Thus, from July 2021, we introduced simultaneous (parallel method) with approval...
We studied the effect of atrial natriuretic factor (ANF) on calcium influx and efflux in rat adrenal glomerulosa cells stimulated by angiotensin II (Ang II) or potassium ion, observed how ANF inhibits initial sustained phases aldosterone response to Ang K+ using a superfusion system dispersed cells. (8 mM) significantly increased Ca2+ rate compared with basal (0.91 +/- 0.10 vs 0.42 0.04 nmol/min/10(6) cells; p less than 0.01). (10(-8) M) did not inhibit K+-induced increase (0.99 0.18 cells)....