A5043799958- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Surgical Simulation and Training
- Colorectal Cancer Screening and Detection
- Augmented Reality Applications
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Minimally Invasive Surgical Techniques
- Pancreatitis Pathology and Treatment
- Soft Robotics and Applications
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
Osaka University
2008-2024
Osaka National Hospital
2012-2024
Kansai Medical University
2019-2024
University of Colorado Anschutz Medical Campus
2024
Satou Hospital
2021
Osaka City General Hospital
2019
Osaka Prefectural Medical Center
2016-2019
Kansai University
2019
The Japanese Society of Gastroenterological Surgery
2015
Kyushu University
2010
Abstract Purpose: Myofibroblasts, which are specifically differentiated fibroblasts, thought to play a central role in the desmoplastic reaction, dynamic stromal change closely associated with cancer development. Although fundamental studies suggest that myofibroblasts may either facilitate or inhibit progression, cumulative evidence supports their promoting tumor progression. The aim of this study was assess value stroma as an indicator disease recurrence after colorectal surgery....
Although cancer is a disease with genetic and epigenetic origins, the possible effects of reprogramming by defined factors remain to be fully understood. We studied induction or inhibition cancer-related genes immature status-related whose alterations have been reported in gastrointestinal cells. Retroviral-mediated introduction induced pluripotent stem (iPS) cell was necessary for inducing expression proteins, including Nanog, Ssea4, Tra-1-60, Tra-1-80 esophageal, stomach, colorectal,...
In Brief Objective: The aims of this prospective study were to investigate the true incidence portal or splenic vein thrombosis (PSVT) after elective laparoscopic splenectomy using contrast-enhanced computed tomography (CT) scan, and outcome anticoagulant therapy for PSVT. Summary Background Data: Although rare, venous system is considered a possible cause death splenectomy. reported ultrasonographically detected PSVT open ranges from 6.3% 10%. Methods: Twenty-two patients underwent (LS...
There are currently no accurate serum markers for detecting early risk of colorectal cancer (CRC). We therefore developed a non-targeted metabolomics technology to analyse the pre-treatment CRC patients in order discover putative metabolic associated with CRC. Using tandem-mass spectrometry (MS/MS) high throughput MS we evaluated utility selected and this discriminating between healthy subjects. Biomarker discovery was performed using Fourier transform ion cyclotron resonance mass...
Recent studies have identified vimentin, a type III intermediate filament, among genes differentially expressed in tumours with more invasive features, suggesting an association between vimentin and tumour progression. The aim of this study, was to investigate whether expression colon cancer tissue is clinical relevance. We performed immunostaining 142 colorectal (CRC) samples quantified the amount using computer-assisted image analysis. Vimentin stroma CRC associated shorter survival....
Inconsistent conclusions have been drawn about the clinical significance of micrometastases in lymph nodes (LNs) node-negative colorectal cancer (CRC) patients. We performed a comparative study detection using immunohistochemistry (IHC) by anti-cytokeratin antibody and carcinoembryonic antigen (CEA)-specific reverse-transcriptase polymerase chain reaction (RT-PCR) same patients, an attempt to move closer their application.Sixty-four CRC with RNA good quality available from paraffin-embedded...
Robotic laparoscope positioners are now expected as assisting devices for solo surgery among endoscopic surgeons. In such robotic systems, the human-machine (surgeon-robot) interface is of paramount importance because it means by which surgeon communicates with and controls camera assistant. We have designed a novel interface, called "FAce MOUSe", controlling position laparoscope. The proposed human an image-based system tracks surgeon's facial motions robustly in real time does not require...
Single-site laparoscopic colectomy (SLC) is an emerging concept that, compared with conventional multiport (MLC), yields reduced postoperative pain and improved cosmesis. Complete mesocolic excision (CME) a novel for colon cancer surgery that provides oncologic outcomes; however, there are no reports of SLC CME. We conducted prospective case-control study to evaluate the feasibility safety CME cancer.Prospectively collected data patients stage I-III who underwent (n = 150) or MLC between...
Abstract Purpose: This study aimed to identify novel hypoxia-inducible and prognostic markers in vivo from hypoxic tumor cells. Experimental Design: Using carbonic anhydrase 9 CD34 as a guide for cells, laser capture microdissection was used isolate colorectal cancer (CRC) liver metastases. The samples were analyzed by microarray analysis, parallel with five CRC cell lines cultured under conditions. To evaluate the impact of expression certain genes, total 356 patients or quantitative...
The mechanism behind the spatiotemporal control of cancer cell dynamics and its possible association with proliferation has not been well established. By exploiting intravital imaging technique, we found that motility invasive properties were closely associated cycle. In vivo inoculation human colon cells bearing fluorescence ubiquitination-based cycle indicator (Fucci) demonstrated an unexpected phenomenon: S/G2/M more motile than G1 cells. Microarray analyses showed Arhgap11a,...
Abstract Background Intraperitoneal chemotherapy using paclitaxel is considered an experimental approach for treating peritoneal carcinomatosis. This study aimed to determine the recommended dose, and evaluate clinical efficacy safety, of combination intravenous gemcitabine, nab-paclitaxel intraperitoneal in patients with pancreatic cancer metastasis. Methods The frequencies dose-limiting toxicities were evaluated, dose was determined phase I. primary endpoint II analysis overall survival...