A5073415346- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Intraperitoneal and Appendiceal Malignancies
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Tracheal and airway disorders
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Dysphagia Assessment and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- Glycosylation and Glycoproteins Research
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Multiple and Secondary Primary Cancers
- Nutrition and Health in Aging
Kindai University
2016-2025
Osaka International Cancer Institute
2024
Japan Clinical Cancer Research Organization
2022
Kindai University Hospital
2021
European Neuroendocrine Tumor Society
2018
Osaka University
2003-2012
Sakai Municipal Hospital
2010
Victor Babeș University of Medicine and Pharmacy Timișoara
2010
Society for Endocrinology
2007
Toyo Suisan (Japan)
2006
Objective: The aim of the study was to determine optimal extent lymph node dissection for 2 histological types esophagogastric junction (EGJ) tumors based on incidence metastasis in a prospective nationwide multicenter study. Background: Because most previous studies were retrospective, surgical procedure EGJ has not been standardized. Methods: Patients with cT2-T4 adenocarcinoma or squamous cell carcinoma located within 2.0 cm enrolled before surgery. Surgeons dissected all nodes...
Abstract This is the second half of English edition Japanese Classification Esophageal Cancer, 12th Edition that was published by Japan Society in 2022.
In Brief Objective: The aims of this prospective study were to investigate the true incidence portal or splenic vein thrombosis (PSVT) after elective laparoscopic splenectomy using contrast-enhanced computed tomography (CT) scan, and outcome anticoagulant therapy for PSVT. Summary Background Data: Although rare, venous system is considered a possible cause death splenectomy. reported ultrasonographically detected PSVT open ranges from 6.3% 10%. Methods: Twenty-two patients underwent (LS...
Etoposide plus cisplatin (EP) and irinotecan (IP) are commonly used as community standard regimens for advanced neuroendocrine carcinoma (NEC).To identify whether EP or IP is a more effective regimen in terms of overall survival (OS) patients with NEC the digestive system.This open-label phase 3 randomized clinical trial enrolled chemotherapy-naive aged 20 to 75 years who had recurrent unresectable (according 2010 World Health Organization classification system) arising from gastrointestinal...
Hepatoma-derived growth factor (HDGF) is a unique nuclear/growth and might play an important role in the development progression of carcinomas. In present study, association HDGF expression with recurrence prognosis gastric carcinoma was examined.HDGF 317 patients (233 males 84 females) ages ranging from 26 to 81 years (median, 60 years) analyzed by immunohistochemistry. Samples >90% tumor cells express positive immunoreactivity similar or stronger than that endothelial both for nucleus...
<i>Objective:</i> Esophageal squamous cell carcinoma (ESCC) is refractory to current therapeutic regimens and more effective therapies are imperative. To this end, we conducted a multicenter phase I/II trial of docetaxel, cisplatin, fluorouracil (DCF) combination chemotherapy for ESCC. <i>Methods:</i> The study subjects were 46 patients with advanced or recurrent Treatment included docetaxel at 60, 70, 75 mg/m<sup>2</sup>, cisplatin 70...
Molecular targeted therapy is expected to be a promising therapeutic approach for the treatment of esophageal squamous cell carcinoma (ESCC); however, gene amplification status molecular genes in ESCC remains largely unclear. The EGFR, HER2, FGFR2 and MET was examined using real-time PCR-based copy number assay 245 surgical specimens formalin-fixed, paraffin-embedded samples. Fluorescence situ hybridization (FISH) comparative genomic analyses verified results assay. EGFR mutation detected...
BALB/c radiation leukemia RL male 1 is an immunogenic tumor. We established bulk and cloned cytotoxic T lymphocyte (CTL) lines from regressor (BALB/c x C57BL/6)F1 (CB6F1) spleen cells that recognized specifically. then obtained antigen peptide by CTL acid extraction. Analysis of the extract reversed-phase high performance liquid chromatography (HPLC) on a semipreparative C18 column revealed fractions eluted in 23 min (peak a) 26 b) showed sensitization activity P815 target for specific CTL....
For esophageal cancer patients, the gastric tube is first choice as an substitute, with colon or jejunum being used when stomach cannot be used. We retrospectively compared these two methods from viewpoint of peri-operative complications and long-term bodyweight alteration. From 1998 to 2005 53 patients who had undergone subtotal esophagectomy due thoracic cancers were given reconstruction (28 cases) (25 cases). Both intestines reconstructed via subcutaneous route anastomosed internal...
// Yosuke Togashi 1 , Tokuzo Arao Hiroaki Kato 2 Kazuko Matsumoto Masato Terashima Hidetoshi Hayashi Marco A de Velasco Yoshihiko Fujita Hideharu Kimura Takushi Yasuda Hitoshi Shiozaki and Kazuto Nishio Department of Genome Biology, Kinki University Faculty Medicine, Osaka-Sayama, Osaka, Japan Surgery, Correspondence: Nishio, email: Keywords : oral cancer overexpressed 1, esophageal squamous cell cancer, pyrroline-5-carboxylate reductase, proline metabolism, reactive oxygen species. Received...
Objective: We conducted a multicenter randomized prospective phase 2 trial of chemoradiotherapy (CRT) versus chemotherapy (CT) as initial induction therapy for conversion surgery (CS) in clinical T4b esophageal cancer. compared treatment effects and adverse events (AEs). Summary Background Data: Although followed by CS is potentially curative cancer, the optimal unclear. Methods: Ninety-nine patients with cancer were randomly allocated to (Group A, n = 49) or CT B, 50) treatment. CRT...
To improve the prognosis of clinically resectable type 4 or large 3 gastric cancer (GC), we performed a phase I/II study neoadjuvant-radiotherapy combined with S-1 plus cisplatin. Phase I, standard + dose-escalation design, was to define recommended II dose. Efficacy and safety were evaluated in II. The three dose levels as follows: level 0, 60 mg/m2 on days 1-14 cisplatin day 1; 1, 80 2, 22-35, 1 22. starting 1. Radiotherapy delivered at total 40 Gy fractions for weeks. A six patients...
Abstract Aim Upfront chemotherapy (uCT) or upfront chemoradiotherapy (uCRT) followed by surgery is generally accepted as the standard treatment for patients with locally advanced esophageal cancer. A substantial proportion of achieve a pathological complete response (pCR) primary tumor treatment. This retrospective study aimed to clarify prognostic factors cancer who pCR in after and whether prognosis receive uCT differs from that uCRT. Methods included 121 achieved 40 Univariate...