Nao Fujimori
A5024065137- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Lung Cancer Research Studies
- Esophageal and GI Pathology
- Neuroblastoma Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- IgG4-Related and Inflammatory Diseases
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biliary and Gastrointestinal Fistulas
- Cancer Treatment and Pharmacology
- Diabetes and associated disorders
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Abdominal vascular conditions and treatments
- Cancer Immunotherapy and Biomarkers
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
Kyushu University
2015-2025
Hudson Institute
2023
The Japanese Society of Gastroenterological Surgery
2022
Japan Clinical Cancer Research Organization
2022
Kyushu University Hospital
2022
National Kyushu Medical Center
2013-2020
National Institute of Diabetes and Digestive and Kidney Diseases
2017
National Institutes of Health
2017
Fukuoka University
2015
National Hospital Organization Kyushu Cancer Center
2008
Objectives This retrospective multicenter study aimed to clarify the clinical impact of endotherapy for painless pancreatic duct (PD) stones compared with that in patients who received conservative treatment without endotherapy. Methods We enrolled 268 suffering from chronic pancreatitis PD (145 and 123 endotherapy) evaluated on radiological outcomes. Results When was set as a reference, complete clearance targeted decreased relative risk atrophy parenchyma after inclusion (hazard ratio [HR]...
Abstract Neuroendocrine neoplasms (NENs) are rare that occur in various organs and present with diverse clinical manifestations. Pathological classification is important the diagnosis of NENs. Treatment strategies must be selected according to status differentiation malignancy by accurately determining whether neoplasm functioning or nonfunctioning, degree disease progression, presence metastasis. The newly revised Clinical Practice Guidelines for Gastroenteropancreatic Neoplasms (GEP-NENs)...
Etoposide plus cisplatin (EP) and irinotecan (IP) are commonly used as community standard regimens for advanced neuroendocrine carcinoma (NEC).To identify whether EP or IP is a more effective regimen in terms of overall survival (OS) patients with NEC the digestive system.This open-label phase 3 randomized clinical trial enrolled chemotherapy-naive aged 20 to 75 years who had recurrent unresectable (according 2010 World Health Organization classification system) arising from gastrointestinal...
We compared the efficacy of modified 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (mFOLFIRINOX) with that gemcitabine plus nab-paclitaxel (GnP) for locally advanced pancreatic cancer (LAPC).Patients untreated LAPC were randomly assigned (1:1) to receive mFOLFIRINOX or GnP. One-year overall survival (OS) was primary endpoint. The major secondary end-points included progression-free (PFS), response rate (RR), carbohydrate antigen 19-9 (CA19-9) response, adverse events. sample size...
Endoscopic ultrasound-guided tissue acquisition (EUS-TA) plays a crucial role in the diagnosis of pancreatic tumors. The present study aimed to investigate current status needle tract seeding (NTS) after EUS-TA tumors based on nationwide survey Japan.
Objectives Endoscopic ultrasound‐guided fine‐needle aspiration/biopsy (EUS‐FNA/B) is the gold standard for diagnosing gastric subepithelial lesions (SELs), but smaller than 20 mm remains challenging. We developed traction‐assisted EUS‐FNB (TA‐EUS‐FNB) using clip‐with‐thread method to enhance diagnostic accuracy by stabilizing lesion and providing counter‐traction easier needle access. This study evaluates effectiveness of TA‐EUS‐FNB in small SELs. Methods In this prospective, randomized,...
Pancreatic neuroendocrine tumors (pNETs) are histologically categorized according to the WHO 2010 classification by their mitotic index or Ki-67 as G1, G2, G3. The present study examined efficacy of endoscopic ultrasonography (EUS) and EUS-guided fine-needle aspiration (EUS-FNA) in diagnosis grading pNET.We retrospectively reviewed 61 pNETs 51 patients who underwent EUS between January 2007 June 2014. All lesions were pathologically diagnosed surgical resection EUS-FNA. We evaluated...
Depth of response (DpR; maximum % reduction from baseline in sum the target lesion diameters) has demonstrated potential predicting prognosis several malignancies. However, its role locally advanced pancreatic cancer (LAPC) is still unclear. In JCOG1407, modified FOLFIRINOX (mFOLFIRINOX) and gemcitabine plus nab-paclitaxel (GnP) exhibited comparable efficacy for LAPC. this exploratory analysis using data we focused on association between DpR prognosis. was classified into three groups at...
Although various self-expandable metallic stents (SEMSs) for malignant hilar biliary obstruction (MHBO) have been introduced, the optimal SEMS MHBO has not yet established. This study aimed to evaluate outcomes of transpapillary placement an uncovered laser-cut with ultra-thin delivery sheath (YABUSAME) MHBO. multicenter, prospective was conducted in 11 hospitals 10 months (from March 2022 December 2022). The primary outcome stent patency rate at 6 months. Key secondary were technical...
Multiple endocrine neoplasia type 1 (MEN1) is an inherited autosomal dominant disease presenting with pancreatic neuroendocrine tumors (pNETs), parathyroid tumors, or pituitary tumors. Using the PubMed database, we reviewed literature on information regarding proper diagnosis and treatment of MEN1-associated pNET. Many cases pNET are functioning pNETs. Gastrinomas insulinomas tend to occur frequently in duodenum pancreas, respectively. In addition diagnostic imaging, selective arterial...
Although patients with autoimmune pancreatitis (AIP) tend to have concurrent diverse disorders, very few studies focused on diabetes mellitus (DM) coexisting AIP.In total 102 AIP DM were divided into three groups. Those before the onset of labeled group A (n=35), those who developed and simultaneously B (n=58) after steroid therapy for C (n=9). The characteristics among groups evaluated.No significant differences noted in age However, mean duration was significantly longer (8.7 years) than...
Although chromogranin A (CGA) is a useful marker for pancreatic neuroendocrine tumors ( pNET ) in the West, its usefulness Japanese populations unclear. To assess this, we evaluated serum CGA levels 189 patients with various diseases, including proven n = 69), cancer (PC) 50), chronic pancreatitis (CP) 50) and autoimmune (AIP) 20), 112 normal controls (controls) using an ELISA kit. The mean level of was significantly higher than any other groups (407.8 ± 984.6 ng/ mL [ ] vs 91.8 101.8 [PC],...
ObjectiveDespite an increase in the number of Japanese patients with pancreatic neuroendocrine neoplasms, long-term outcomes and prognostic factors, especially for those advanced disease, remain unclear.
Although the combination of nanoliposomal irinotecan plus fluorouracil/folinic acid (nal-IRI/FF) exhibited survival benefits in gemcitabine-refractory patients with advanced pancreatic cancer (APC) phase III NAPOLI-1 trial, there is limited data on efficacy and safety this regimen real-world settings Japan. This multicenter, prospective observational study enrolled APC who received nal-IRI/FF after a gemcitabine-based from July 2020 to June 2021. We collected analyzed clinical conducted...