A5084372818- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Neuroendocrine Tumor Research Advances
- Nutrition and Health in Aging
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Hernia repair and management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Abdominal Surgery and Complications
- Helicobacter pylori-related gastroenterology studies
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- Cancer Diagnosis and Treatment
- Enhanced Recovery After Surgery
- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
Shimane University
2015-2024
Kajima Corporation (Japan)
2021-2023
Matsue Red Cross Hospital
2022
Yamamoto Hospital
2022
Red Cross Hospital
2022
Tsuda University
2022
Shimane University Hospital
2022
Japan Clinical Cancer Research Organization
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Pfizer (Japan)
2019
Etoposide plus cisplatin (EP) and irinotecan (IP) are commonly used as community standard regimens for advanced neuroendocrine carcinoma (NEC).To identify whether EP or IP is a more effective regimen in terms of overall survival (OS) patients with NEC the digestive system.This open-label phase 3 randomized clinical trial enrolled chemotherapy-naive aged 20 to 75 years who had recurrent unresectable (according 2010 World Health Organization classification system) arising from gastrointestinal...
The biological activities of interleukin-17 (IL-17), a newly cloned cytokine, have not been fully elucidated. present study was designed to assess the in vitro and vivo effect transfecting IL-17 gene into tumor cells.A complementary DNA (cDNA) encoding human (hIL-17) obtained by polymerase chain reaction amplification from CD4+ T cell cDNA library inserted plasmid pRc/cytomegalovirus construct an expression vector for hIL-17 gene. Murine Meth-A fibrosarcoma cells were transfected with using...
An ideal tumor marker should be capable of being detected at any stage the disease. However, gastric cancer patients do not always have elevated serum carcinoembryonic antigen (CEA) levels, even in advanced cases. Recently, several studies investigated associations between preoperative PNI and postoperative long-term outcomes. In this study, we focused on significance prognostic nutritional index (PNI) as a potential predictor survival resectable with normal CEA levels. We retrospectively...
The purpose of the present study is to investigate utility prognostic nutritional index (PNI) as a simple and readily available marker in esophageal squamous cell carcinoma (ESCC).We retrospectively analyzed 169 patients who underwent potentially curative esophagectomy, for histologically verified ESCC. We decided set optimal cutoff value preoperative PNI levels at 49.2, based on cancer-specific survival (CSS) overall (OS) by receiver operating characteristic curve analysis.Multivariate...
Despite recent improvements in early detection, progress surgical techniques, and development of chemoradiation therapies, prognosis esophageal cancer remains poor. The aim the present study was to assess whether Glasgow Prognostic Score (GPS), an inflammation-based prognostic score, has value independent conventional clinicopathological criteria patients undergoing curative resection for cancer, even elderly patients.We retrospectively reviewed database 141 consecutive with histologically...
It is now clear that cancer survival determined not only by tumor pathology but also host-related factors, in particular, nutritional status and systemic inflammation. desirable the essential properties of any scale designed or intended to be used for prediction are simple, convenient, objective. In this study, we retrospectively reviewed database patients who underwent curative surgery esophageal our department evaluate controlling (CONUT) neutrophil-lymphocyte ratio (NLR) as predictors...
Several inflammatory response biomarkers, including lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte (NLR), and platelet-to-lymphocyte (PLR) have been reported to predict survival in various cancers. The aim of this study is evaluate the clinical value these biomarkers patients undergoing curative resection for esophageal cancer. LMR, NLR PLR were calculated 147 consecutive who underwent esophagectomy between January 2006 February 2015. We examined prognostic significance NLR,...
It is now widely recognized that outcomes in cancer patients are not determined by their tumor characteristics alone. In this study, we retrospectively analyzed the clinical data of esophageal to evaluate impact red blood cell distribution width (RDW), platelet (PDW), and mean volume (MPV) on cancer-specific survival (CSS). We reviewed a database 144 consecutive who underwent curative esophagectomy for squamous carcinoma at our institute between 2006 2014. multivariate analysis, pathological...
The aim of the current study was to investigate impact preoperative red cell distribution width (RDW) value on overall survival (OS) and cancer-specific (CSS) gastric cancer patients.A total 366 patients who underwent curative gastrectomy were retrospectively reviewed. Among them, RDW evaluated in 165 non-elderly 201 elderly patients.Multivariate analysis revealed that pathological stage (pStage), RDW, carcinoembryonic antigen (CEA), independent prognostic factors OS, while pStage CSS. In...
// Noriyuki Hirahara 1 , Takeshi Matsubara Yusuke Fujii Shunsuke Kaji Ryoji Hyakudomi Tetsu Yamamoto Yuki Uchida Yoshiko Miyazaki Kazunari Ishitobi Yasunari Kawabata and Yoshitsugu Tajima Department of Digestive General Surgery, Shimane University Faculty Medicine, Izumo, Shimane, Japan Correspondence to: Hirahara, email: norinorihirahara@yahoo.co.jp Keywords: geriatric nutritional risk index; overall survival; cancer-specific gastric cancer; elderly patients Received: April 20, 2020...
Background: Systemic immune-inflammation index (SII)-comprising platelet, neutrophil, and lymphocyte count-is an objective reliable biomarker for predicting the prognosis in cancer patients because it comprehensively reflects balance between host inflammatory immune responses. In this study, we clarified prognostic impact of immunoinflammation-based indices, i. e. SII, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), gastric patients. Results: multivariate analysis, American...
Recent evidence suggests that preoperative malnutrition may lead to poor survival in cancer patients. This study aimed determine the ability of prognostic nutritional index (PNI) predict gastric patients.Two hundred and eighteen patients who had undergone laparoscopic gastrectomy were retrospectively reviewed via propensity score-matched analysis.In multivariate analysis overall patients, pTNM stage, carcinoembryonic antigen, PNI independent predictors (OS), stage cancer-specific (CSS)....
Background: Esophageal malignancies have a high morbidity rate worldwide, and minimally invasive surgery has emerged as the primary approach for treating esophageal cancer. In recent years, there been increasing discussion about potential of employing inflatable mediastinoscopic laparoscopic approaches an option esophagectomy. Building on modification technique, we introduced secondary to further minimize surgical trauma. Methods: We conducted retrospective analysis patients who underwent...
Heavy water (deuterium oxide: D2O) contains a neutron and proton in its hydrogen atoms shows variety of biologic activities different from normal light water. In the present study cytotoxic cytostatic activity D2O was assessed using BALB/c-3T3 fibroblast cell line four human digestive organ cancer lines, i.e. HepG2 hepatic, Panc-1 pancreatic, KATO-3 gastric Colo205 colonic lines. Against showed significant effects MTT assay Trypan blue dye exclusion assay, at concentrations higher than 30%...
Here we report the method of anastomosis based on double stapling technique (hereinafter, DST) using a trans-oral anvil delivery system (EEATM OrVilTM) for reconstructing esophagus and lifted jejunum following laparoscopic total gastrectomy or proximal gastric resection. As basic technique, employed Roux-en-Y reconstruction, tract end-to-side was used cut-off stump jejunum. We EEATM OrVilTM as device that permitted mechanical purse-string suture similarly to conventional EEA, endo-Surgitie....
Unnecessary intra-abdominal drain insertion must be avoided, but little is known about the value of prophylactic drainage following laparoscopic distal gastrectomy (LDG). In this study, we investigated significance placement after LDG for gastric cancer. Seventy-eight consecutive patients with cancer who underwent in our department were retrospectively analyzed. The divided into two groups according to a LDG. ‘drain group’ comprised 45 routine use drain, and ‘no-drain 33 did not undergo an...