A5083990843- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biliary and Gastrointestinal Fistulas
- Plant Virus Research Studies
- Plant-Microbe Interactions and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Plant Stress Responses and Tolerance
- Gastric Cancer Management and Outcomes
- Plant and Fungal Interactions Research
- Pancreatitis Pathology and Treatment
- Bacteriophages and microbial interactions
- Plant Parasitism and Resistance
- Inflammatory Biomarkers in Disease Prognosis
- Liver Diseases and Immunity
- Renal cell carcinoma treatment
- Esophageal Cancer Research and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Legume Nitrogen Fixing Symbiosis
- Plant nutrient uptake and metabolism
- interferon and immune responses
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- MRI in cancer diagnosis
- Insect and Pesticide Research
University of Tsukuba
2024
Nara Institute of Science and Technology
2017-2021
Kyoto University
2011-2017
Shimane University
2012-2016
Nagasaki University
1999-2010
Abstract Legumes control root nodule symbiosis (RNS) in response to environmental nitrogen availability. Despite the recent understanding of molecular basis external nitrate-mediated RNS, it remains mostly elusive how plants regulate physiological processes depending on internal status. In addition, iron (Fe) acts as an essential element that enables symbiotic fixation; however, mechanism Fe accumulation nodules is poorly understood. Here, we focus transcriptome status during RNS Lotus...
ABSTRACT Assembly of viral replicase complexes eukaryotic positive-strand RNA viruses is a regulated process: multiple and host components must be assembled on intracellular membranes ordered into quaternary capable synthesizing RNAs. However, the molecular mechanisms underlying this process are poorly understood. In study, we used model virus, Red clover necrotic mosaic virus (RCNMV), whose complex can detected readily as 480-kDa functional protein complex. We found that heat shock proteins...
Despite recent improvements in early detection, progress surgical techniques, and development of chemoradiation therapies, prognosis esophageal cancer remains poor. The aim the present study was to assess whether Glasgow Prognostic Score (GPS), an inflammation-based prognostic score, has value independent conventional clinicopathological criteria patients undergoing curative resection for cancer, even elderly patients.We retrospectively reviewed database 141 consecutive with histologically...
ABSTRACT Viruses employ an alternative translation mechanism to exploit cellular resources at the expense of host mRNAs and allow preferential translation. Plant RNA viruses often lack both a 5′ cap 3′ poly(A) tail in their genomic RNAs. Instead, cap-independent enhancer elements (CITEs) located untranslated region (UTR) mediate Although eukaryotic initiation factors (eIFs) or ribosomes have been shown bind 3′CITEs, our knowledge is still limited for mechanism, especially factors. Here, we...
The outcome after surgery for intrahepatic cholangiocarcinoma (ICC) is dismal and data on long-term survival are not available. This study evaluated prognostic indicators characteristic features of survivors hepatic resection ICC.Thirty-one patients who had undergone ICC were studied. Univariate multivariate analyses clinicopathological included an intraductal papillary carcinoma component (IDPCC) in the tumour, which was defined as histological demonstration cancer cells growing a fashion...
Abstract Background This study assessed the value of time–signal intensity curve (TIC) obtained from dynamic magnetic resonance imaging (MRI) in evaluation remnant pancreatic fibrosis after pancreaticojejunostomy patients undergoing pancreaticoduodenectomy. Methods Two modes pancreaticojejunostomy—duct-to-mucosa anastomosis (DMA; 24 patients) and pancreatojejunoserosal (PJSA; 22 patients)—were used 46 consecutive All underwent contrast-enhanced MRI pancreas before Retrospective review images...
<b><i>Objectives:</i></b> To identify the risk factors for clinically relevant pancreatic fistula after distal pancreatectomy with a flexible cartridge stapler, TL60. <b><i>Methods:</i></b> Forty consecutive patients who underwent by TL60 stapler were retrospectively reviewed in association postoperative complications. <b><i>Results:</i></b> The overall morbidity rate was 43% (17 patients), and mortality null. Pancreatic...
In plants, a first layer of inducible immunity is conferred by pattern recognition receptors (PRRs) that bind microbe- and damage-associated molecular patterns to activate pattern-triggered (PTI). PTI strengthened or followed another potent form when intracellular recognize pathogen effectors, termed effector-triggered immunity. Immunity signaling regulators have been reported influence abiotic stress responses as well, yet the governing principles mechanisms remain ambiguous. Here, we...
Abstract Background Helicobacter bilis is considered to be a causative factor in the pathogenesis of biliary cancer. This study investigated prevalence H. colonization system patients with pancreaticobiliary maljunction (PBM). Methods Bile juice and tissue samples were collected from 17 PBM 27 controls who had benign disease without PBM. DNA extracted each sample was subjected polymerase chain reaction (PCR) analysis for pylori. Results PCR assays revealed that 12 positive DNA, compared...
The present study was designed to investigate whether an inducible nitric oxide synthase (iNOS)-specific inhibitor, ONO-1714 [(1S, 5S, 6R, 7R)-7-chloro-3-imino-5-methyl-2-azabicyclo[4.1.0] heptane], could prevent inflammation-associated biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters underwent choledochojejunostomy and then received subcutaneous injections of the chemical carcinogen N -nitrosobis(2-oxopropyl)amine every 2 weeks at a dose 10 mg/kg body wt,...
Abstract Pattern recognition receptors (PRRs) bind microbe- and damage-associated molecular patterns (MAMPs/DAMPs, respectively) to enhance host immunity in animals plants. Here, we report that PRRs also confer salt tolerance the model plant Arabidopsis thaliana following of cognate ligands, such as bacterial flagellin EF-Tu endogenous Pep peptides. Pattern-triggered (PTST) requires PRR-associated kinases BAK1 BIK1 , NADPH oxidase RBOHD . Transcriptome profiling reveals an inventory PTST...
The histological detection of lymph node metastasis in patients with gallbladder carcinoma is major prognostic significance. However, it may be difficult to identify nodal involvement by conventional pathological examination hematoxylin-eosin (HE)-stained sections when metastases are microscopic size. In the present study, an attempt was made detect precisely from carcinoma, even low-power examination, using immunohistochemistry anti-cytokeratin antibody.A total 431 specimens dissected...
The prognosis of patients with pancreatic carcinoma remains very poor. To improve the therapeutic results, early detection this cancer is needed. present study was performed to detect pancreas-specific gene, chymotrypsinogen, in peripheral blood from by using reverse transcription polymerase chain reaction (RT-PCR) order evaluate clinical significance gene. Ten carcinoma, two acute pancreatitis, three chronic pancreatitis and ten control subjects were examined for presence chymotrypsinogen...