A5101638339- Gastric Cancer Management and Outcomes
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Radiation Detection and Scintillator Technologies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Radiation Effects in Electronics
- Tracheal and airway disorders
- Cancer, Lipids, and Metabolism
- Cardiac, Anesthesia and Surgical Outcomes
- Enhanced Recovery After Surgery
- Dental Radiography and Imaging
- Lung Cancer Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pneumothorax, Barotrauma, Emphysema
- Colorectal Cancer Treatments and Studies
- Congenital Diaphragmatic Hernia Studies
- Aortic Disease and Treatment Approaches
- Atomic and Subatomic Physics Research
Hokkaido University
2015-2024
Kyoto University
2024
Hitachi (Japan)
2009-2024
National Cancer Center Hospital East
2022
National Cancer Center
2022
Himeji Medical Center
2022
Juntendo University
2022
Yamato Municipal Hospital
2021
ShinKokura Hospital
2021
Shimane University
2012-2020
An ideal tumor marker should be capable of being detected at any stage the disease. However, gastric cancer patients do not always have elevated serum carcinoembryonic antigen (CEA) levels, even in advanced cases. Recently, several studies investigated associations between preoperative PNI and postoperative long-term outcomes. In this study, we focused on significance prognostic nutritional index (PNI) as a potential predictor survival resectable with normal CEA levels. We retrospectively...
The purpose of the present study is to investigate utility prognostic nutritional index (PNI) as a simple and readily available marker in esophageal squamous cell carcinoma (ESCC).We retrospectively analyzed 169 patients who underwent potentially curative esophagectomy, for histologically verified ESCC. We decided set optimal cutoff value preoperative PNI levels at 49.2, based on cancer-specific survival (CSS) overall (OS) by receiver operating characteristic curve analysis.Multivariate...
Despite recent improvements in early detection, progress surgical techniques, and development of chemoradiation therapies, prognosis esophageal cancer remains poor. The aim the present study was to assess whether Glasgow Prognostic Score (GPS), an inflammation-based prognostic score, has value independent conventional clinicopathological criteria patients undergoing curative resection for cancer, even elderly patients.We retrospectively reviewed database 141 consecutive with histologically...
The aim of the current study was to investigate impact preoperative red cell distribution width (RDW) value on overall survival (OS) and cancer-specific (CSS) gastric cancer patients.A total 366 patients who underwent curative gastrectomy were retrospectively reviewed. Among them, RDW evaluated in 165 non-elderly 201 elderly patients.Multivariate analysis revealed that pathological stage (pStage), RDW, carcinoembryonic antigen (CEA), independent prognostic factors OS, while pStage CSS. In...
// Noriyuki Hirahara 1 , Takeshi Matsubara Yusuke Fujii Shunsuke Kaji Ryoji Hyakudomi Tetsu Yamamoto Yuki Uchida Yoshiko Miyazaki Kazunari Ishitobi Yasunari Kawabata and Yoshitsugu Tajima Department of Digestive General Surgery, Shimane University Faculty Medicine, Izumo, Shimane, Japan Correspondence to: Hirahara, email: norinorihirahara@yahoo.co.jp Keywords: geriatric nutritional risk index; overall survival; cancer-specific gastric cancer; elderly patients Received: April 20, 2020...
Purpose: In spot‐scanning proton therapy, the interplay effect between tumor motion and beam delivery leads to deterioration of dose distribution. To mitigate impact motion, gating in combination with repainting is one most promising methods that have been proposed. This study focused on a synchrotron‐based therapy system integrated real‐time monitoring. The authors investigated effectiveness terms both delivered distribution irradiation time by conducting simulations patients’ data....
Background: Systemic immune-inflammation index (SII)-comprising platelet, neutrophil, and lymphocyte count-is an objective reliable biomarker for predicting the prognosis in cancer patients because it comprehensively reflects balance between host inflammatory immune responses. In this study, we clarified prognostic impact of immunoinflammation-based indices, i. e. SII, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), gastric patients. Results: multivariate analysis, American...
The main purpose in this study was to present the results of beam modeling and how authors systematically investigated influence double triple Gaussian proton kernel models on accuracy dose calculations for spot scanning technique.The important treatment planning software (TPS) because energy, position, absolute had be determined by TPS technique. distribution calculated convolving in-air fluence with kernel. in-water 3D an infinitesimal pencil consisted integral depth (IDD) a lateral...
An efficient synthesis of the C1−C19 segment aplyronine A is described. Stereoselective construction C14−C15 (E)-trisubstituted double bond and C13 stereocenter was achieved by using an asymmetric Nozaki−Hiyama−Kishi coupling.
In the authors' proton therapy system, patient-specific aperture can be attached to nozzle of spot scanning beams shape an irradiation field and reduce lateral fall-off. The authors herein verified this system for clinical application.The prepared four types systems equipped with energy absorber irradiate shallow regions less than 4 g/cm(2). was made 3-cm-thick brass maximum water equivalent penetration used estimated 15 measured in-air profiles at isocenter plane integral depth doses...
Recent evidence suggests that preoperative malnutrition may lead to poor survival in cancer patients. This study aimed determine the ability of prognostic nutritional index (PNI) predict gastric patients.Two hundred and eighteen patients who had undergone laparoscopic gastrectomy were retrospectively reviewed via propensity score-matched analysis.In multivariate analysis overall patients, pTNM stage, carcinoembryonic antigen, PNI independent predictors (OS), stage cancer-specific (CSS)....
Abstract We have developed physical and biological beam modeling for carbon scanning therapy at the Osaka Heavy Ion Therapy Center (Osaka HIMAK). Carbon irradiation is based on continuous scanning, which adopts hybrid energy changes using both accelerator binary range shifters in nozzles. The dose calculation a triple Gaussian pencil‐beam algorithm, we thus method measurements Monte Carlo simulation Gaussian. exploited model conventional linear‐quadratic (LQ) photon equivalent dose, without...
Purpose To evaluate the biological effects of proton beams as part daily clinical routine, fast and accurate calculation dose‐averaged linear energy transfer ( LET d ) is required. In this study, we have developed analytical method based on pencil‐beam algorithm PBA considering off‐axis enhancement by secondary protons. This ‐ dLET was then validated using Monte Carlo simulation MCS results. Methods , values were assigned separately for each individual dose kernel . For kernel, employed a...
Unnecessary intra-abdominal drain insertion must be avoided, but little is known about the value of prophylactic drainage following laparoscopic distal gastrectomy (LDG). In this study, we investigated significance placement after LDG for gastric cancer. Seventy-eight consecutive patients with cancer who underwent in our department were retrospectively analyzed. The divided into two groups according to a LDG. ‘drain group’ comprised 45 routine use drain, and ‘no-drain 33 did not undergo an...
Treatment of superficial tumors that move with respiration (e.g. lung tumors) using spot-scanning proton therapy (SSPT) is a high-priority research area. The recently developed real-time image-gated beam (RGPT) system has proven to be useful for treating moving deep inside the liver. However, when tumors, proton's range small and so sizes straggling, making Bragg-peaks extremely sharp compared those located in deep-seated tumors. extreme sharpness not always beneficial because it...
Abstract Background We describe a novel scoring system, namely the inflammatory response biomarker (IRB) score. The aim of this study is to evaluate clinical value IRB score in patients undergoing curative resection for esophageal squamous cell carcinoma (SCC). Methods retrospectively reviewed who underwent esophagectomy. evaluated both non‐elderly (<70 years) and elderly (≥70 SCC patients. was determined as follows: high lymphocyte‐to‐monocyte ratio (LMR) (>4),...
// Noriyuki Hirahara 1 , Takeshi Matsubara Yusuke Fujii Shunsuke Kaji Ryoji Hyakudomi Tetsu Yamamoto Yuki Uchida Yoshiko Miyazaki Kazunari Ishitobi Yasunari Kawabata and Yoshitsugu Tajima Department of Digestive General Surgery, Shimane University Faculty Medicine, Izumo, 693-8501, Japan Correspondence to: Hirahara, email: norinorihirahara@yahoo.co.jp Keywords: geriatric nutritional risk index; esophageal squamous cell carcinoma; curative esophagectomy; cancer-specific survival; pathological...