A5005018426- Pharmacy and Medical Practices
- Pharmaceutical Practices and Patient Outcomes
- Esophageal and GI Pathology
- Glycosylation and Glycoproteins Research
- Lipid Membrane Structure and Behavior
- Carbohydrate Chemistry and Synthesis
- Biochemical Analysis and Sensing Techniques
- Pharmaceutical studies and practices
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Colorectal Cancer Treatments and Studies
- Inflammatory Biomarkers in Disease Prognosis
- Acne and Rosacea Treatments and Effects
- Esophageal Cancer Research and Treatment
- Hernia repair and management
- Cancer Treatment and Pharmacology
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Pneumothorax, Barotrauma, Emphysema
- Abdominal Surgery and Complications
- Photodynamic Therapy Research Studies
- Morinda citrifolia extract uses
- Biological Stains and Phytochemicals
- Minimally Invasive Surgical Techniques
Aso Iizuka Hospital
2023
Kyushu University
2021-2022
Ryukoku University
2015-2020
Shimane University
2017-2020
Showa Pharmaceutical University
2020
Hamamatsu Medical Center
2015
Kyoto Women's University
2015
Nihon University
2010
Takatsuki General Hospital
2003-2009
Kyoto University
2008
Atezolizumab plus bevacizumab and lenvatinib are approved frontline therapies for advanced hepatocellular carcinoma (HCC). Patients with HCC continue to have a poor prognosis despite these therapeutic choices. Previous studies reported CD8+ tumor-infiltrating lymphocytes (TILs) as biomarker predict responsiveness systemic chemotherapy. The present study investigated whether evaluating TILs by immunohistochemistry staining of liver tumor biopsy tissues could help the response patients...
The purpose of the present study is to investigate utility prognostic nutritional index (PNI) as a simple and readily available marker in esophageal squamous cell carcinoma (ESCC).We retrospectively analyzed 169 patients who underwent potentially curative esophagectomy, for histologically verified ESCC. We decided set optimal cutoff value preoperative PNI levels at 49.2, based on cancer-specific survival (CSS) overall (OS) by receiver operating characteristic curve analysis.Multivariate...
// Noriyuki Hirahara 1 , Takeshi Matsubara Yusuke Fujii Shunsuke Kaji Ryoji Hyakudomi Tetsu Yamamoto Yuki Uchida Yoshiko Miyazaki Kazunari Ishitobi Yasunari Kawabata and Yoshitsugu Tajima Department of Digestive General Surgery, Shimane University Faculty Medicine, Izumo, Shimane, Japan Correspondence to: Hirahara, email: norinorihirahara@yahoo.co.jp Keywords: geriatric nutritional risk index; overall survival; cancer-specific gastric cancer; elderly patients Received: April 20, 2020...
High-risk human papillomavirus (HPV) infection in conjunctival and lacrimal sac squamous cell carcinomas (SCCs) has been sporadically reported; however, its prevalence, clinicopathologic significance surrogate markers have not fully elucidated. Here, we attempted to clarify these questions Japanese patients with conjunctiva SCCs. We retrospectively collected 51 SCC 7 samples analyzed them for (1) transcriptionally active high-risk HPV using messenger RNA situ hybridization (2) protein...
This study aimed to compare the nutritional status and energy expenditure of hospitalized patients with Crohn's disease (CD) those ulcerative colitis (UC). Twenty-two CD 18 UC were enrolled in this study. We analyzed upon admission by using screening tools including subjective global assessment, malnutrition universal tool, laboratory tests. measured resting (mREE) indirect calorimetry predicted (pREE) was calculated Harris-Benedict equation. Results presented here indicate no significant...
// Noriyuki Hirahara 1 , Takeshi Matsubara Yusuke Fujii Shunsuke Kaji Ryoji Hyakudomi Tetsu Yamamoto Yuki Uchida Yoshiko Miyazaki Kazunari Ishitobi Yasunari Kawabata and Yoshitsugu Tajima Department of Digestive General Surgery, Shimane University Faculty Medicine, Izumo, 693-8501, Japan Correspondence to: Hirahara, email: norinorihirahara@yahoo.co.jp Keywords: geriatric nutritional risk index; esophageal squamous cell carcinoma; curative esophagectomy; cancer-specific survival; pathological...
Various invertebrates inhabiting hydrothermal vents possess sulfur‐oxidizing bacteria in their tissues; however, the mechanisms by which toxic sulfides are delivered to these endosymbionts remain unknown. Recently, detoxification of using thiotaurine, a sulfur‐containing amino acid, has been suggested. In this study, we propose involvement taurine transporter sulfide deep‐sea mussel Bathymodiolus septemdierum demonstrating: (i) abundance its mRNA gill; (ii) activity under wide range...
The role of the lipoamino acids (serratamolide and ornithine lipid), membrane lipid components Serratia marcescens, was examined in phagocytosis phagosome-lysosome fusion human peripheral polymorphonuclear leukocytes. A mutant strain marcescens (NS 38-09) lacking serratamolide actively phagocytosed by PMN, while wild-type 38) producing more resistant to PMN. Phagocytosis killed Staphylococcus aureus coated with acid (serratamolide), showed that they were cells or serratamic actively....
Sphingomonas paucimobilis, a Gram-negative opportunistic pathogen, is actively phagocytosed by human peripheral polymorphonuclear leukocytes (PMN) in vitro. However, when live or killed cells were delipidated, the phagocytic rate was clearly decreased. Therefore, we have investigated physiological role of membrane lipids processes. S. paucimobilis type strain 2395 produces four classes acidic glycosphingolipids (GL-1, GL-2, GL-3, and GL-4) with common components glucuronic acid, 2-hydroxy...
Abstract The solubility in water at 25.0°C of benzene–hydrocarbon binary mixtures has been studied for different ratios between benzene and toluene, ethylbenzene, (o-, m-, p-)xylene, propylbenzene, chlorobenzene, cyclohexane. Aqueous solutions saturated with mixed solutes were prepared by making use the solute vapor. individual constituent mixture was found to change linearly mole fraction over a whole range composition. This is not case benzene–cyclohexane system: each component deviates...
Aspiration pneumonia is a major cause of death in the elderly. In this study, water swallowing test was introduced as method evaluating ability patients, and evaluation team investigated an appropriate procedure for situation our hospital. We also relationship between patients examined by underlying diseases, complications, medicated drugs. test, water-drinking fixed, made based on time required drinking, profile, episodes, which suspected disorder were detected, confirming usefulness...
The foreign body reaction caused by oil contrast medium, Lipiodol, is rare. We present a rare case of inflammatory granuloma in the inguinal hernia sac after hysterosalpingography with lipiodol. A 30-year-old woman who had left growing mass for 7 months Lipiodol examination infertile. About 3 cm soft was palpable on region, and plane CT scan showed multifocal cystic metal concentration. Thus, laparoscopic herniorrhaphy performed to repair confirm contents lesion. filled mucinous contents....
To determine the potential utility of Polygonum hydropiper (tade) as an anti-dementia functional food, present study assessed acetylcholinesterase inhibitory and anti-inflammatory activities tade crude extracts in human cells. Crude were obtained by homogenizing distilled water then heating resulting extracts. The hot aqueous purified centrifugation freeze-dried. inhibition (AChE) was investigated quantitatively Ellman’s method. Furthermore, vitro effects on leukocytes (phagocytic activity,...
Background/Aim: Systemic chemotherapy with atezolizumab plus bevacizumab is approved for unresectable hepatocellular carcinoma (HCC). It necessary to identify probable predictive biomarkers chemotherapies. HCC rim arterial-phase enhancement (APHE) has been linked aggressive tumor activity. Patients and Methods: We studied the efficacy of using computed tomography (CT) or magnetic resonance imaging (MRI) features. In total, 51 patients who underwent CT MRI were classified by feature APHE....
In the future, home medical care will become increasingly significant. The Heisei 24 annual budget request included 2,000,000,000 yen for “the base pharmacy service which provides care,” more is anticipated, and greater expectations are attached to activity in area of pharmacist. However, as actual setting this care, provided by pharmacists still lacking. community-based pharmacist pursued supported pharmaceutical business, deals with issues patient compatibility. Therefore, current model,...
An anti-thrombin substance (M2) was isolated from a culture broth of Rhizopus javanicus. Accumulation M2 reached maximum peak after 14 to 15 days incubation and then decreased. The yield 500 mg 1 L broth. inhibited thrombin activity, its 50% inhibition concentration in reaction mixture containing 50 microL 12.5 NIH unit/mL 200 0.33% bovine fibrinogen 63 microM. had specific activity for thrombin, but it less responsive plasmin, tissue-type plasminogen activator, urokinase, plasma kallikrein...