A5082189270- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Wnt/β-catenin signaling in development and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Multiple and Secondary Primary Cancers
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Renal cell carcinoma treatment
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Cancer-related gene regulation
- Nutrition and Health in Aging
- Enhanced Recovery After Surgery
- Sarcoma Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
Hiroshima City Asa Citizens Hospital
2015-2022
North Medical Center
2022
Hiroshima Prefectural Hospital
2016-2017
Hiroshima University
2004-2016
Citizens Specialty Hospitals
2015-2016
City Hospital
2014-2016
Creative Research Enterprises (United States)
2016
Frontier Science Foundation
2012
Frontier Medical College
2010
Onomichi General Hospital
2002
The mechanisms of carcinogenesis in intrahepatic cholangiocarcinoma (ICC) are not well characterized although alterations several oncogenes and onco-suppressor genes have been reported to occur ICC. In the present study, we focused on Wnt signaling components target by analyzing 24 surgically resected samples Immunohistochemical analysis beta-catenin showed positive staining cytoplasm and/or nucleus 58.3% samples, indicating presence pathway these samples. sequencing analyses, mutations...
In patients with stage IV gastric cancer, systemic chemotherapy is the key treatment. Combination (cis-diamminedichloride platinum plus S-1 and docetaxel S-1) results in long-term survival clinical practice. selected cases, additional (adjuvant) surgery may result further survival. This study aimed to evaluate efficacy of adjuvant following response for advanced cancer. Based on chemotherapy, indications (surgery after chemotherapy) are that resection expected be curative rather than...
To assess the safety of enhanced recovery after surgery (ERAS) program in gastrectomy and influences on nutrition state insulin-resistance.Our ERAS involved shortening fasting periods preoperative carbohydrate loading. Eighty patients were randomly assigned to either conventional group (CG) or (EG). We assessed clinical characteristics postoperative outcomes prospectively. The primary endpoint was noninferiority timely discharge from hospital within 12 d. Secondary endpoints incidence...
We investigated the status of components and target genes Wnt signaling pathway in Japanese anaplastic thyroid cancers (ATCs) present study. Nuclear cytoplasmic positive staining beta-catenin, which might indicate existence alterations pathway, were found 40.9% 63.6% 22 ATC samples, respectively. The adenomatous polyposis coli (APC) Axin 1 gene mutations observed 4.5%, 9.0%, 81.8% Overexpression cyclin D1 c-myc, are was 27.3% 59.1% There no significant correlation between nuclear or...
It is important to discriminate between primary and secondary lung cancer. However, often, the discriminating diagnosis of acinar adenocarcinoma metastasis colorectal cancer based on morphological pathological findings difficult. The purpose this study was evaluate clinical usefulness immunohistochemistry beta-catenin, cytokeratin (CK) 7, CK20 for cancer.We performed CK7, in 19 samples, 10 corresponding samples 11 compared levels accuracy by using antibodies against these antigens.Positive...
Bochdalek hernia is a congenital defect of the diaphragm that usually presents in neonatal period with life-threatening cardiorespiratory distress. It rare for hernias to remain silent until adulthood. Once has been diagnosed, surgical treatment necessary avoid complications such as perforation and necrosis.We present 17-year-old Japanese boy left-upper-quadrant pain two months. Chest radiography showed an elevated left hemidiaphragm. Computed tomography revealed diaphragmatic hernia. The...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of gastrointestinal tract. The tumor size and mitotic count, typical risk category factors, difficult to determine preoperatively. This study aimed evaluate usefulness preoperative 18F-fluoro-2-deoxyglucose positron-emission tomography/computed tomography (18FDG-PET/CT) for predicting malignant potential GISTs by analyzing correlation between maximum standardized uptake value (SUVmax) postoperative factors.Thirty...
We performed a single-institution retrospective study to evaluate the efficacy and toxicities of combination therapy with docetaxel S-1 in patients advanced or recurrent gastric cancer. Eighty-six cancer were enrolled. Patients received docetaxel, 40 mg/m2, on day 1 oral S-1, 80 mg/m2/day, days 14 every 3 weeks. All 84 assessable for response. The overall response rate was 52.4% (44/84) disease control 96.4% (81/84). Median time progression (TTP) survival (OS) 6.5 (95% CI, 4.8-8.1 months)...
A 41-year-old female presented with a 2 cm gastric submucosal tumor that was suspected to be gastrointestinal stromal or other malignancy, and local resection of the stomach performed. However, histopathological examination showed granulomatous gastritis (GG) variety chronic inflammatory cells multinodular granulomas. Although she had past history tuberculosis advanced breast cancer after surgery, there no apparent evidence either metastatic tumor. Other causes GG, such as mycosis, syphilis,...
Abstract A 49-year-old man was admitted to our hospital with a 1-month history of dysphagia. An upper endoscopy revealed lower esophageal submucosal tumor. Immunohistochemical staining the biopsy specimen KIT positivity. Thus, tumor diagnosed as gastrointestinal stromal (GIST). After 6 months imatinib treatment, decreased from 92 mm × 55 80 65 35 in diameter, and surgery performed. The completely resected without rupture, by partial esophagogastric resection through thoracotomy incision,...
Abstract Background Gastrointestinal stromal tumors (GISTs) are morphologically and clinically heterogeneous tumors, their biological behavior is difficult to predict, ranging from benign malignant. The aim of our study was reanalyze the value commonly used prognostic criteria recently reported nomogram in predicting disease recurrence patients with primary resectable GISTs. Methods clinicopathological features 60 GISTs who underwent surgical resection between 1998 2010 at Hiroshima...
Although duodenal perforation is currently an infrequent complication of medical procedures, its incidence in the future predictably will increase as endoscopic treatment neoplasms becomes more frequently used. In some cases, difficult to treat even surgically. We report here a novel technique called 'triple-tube-ostomy' for iatrogenic perforation. Since November 2009, there have been three cases duodenum, due various causes, which we treated with our technique. The main principles are...
The prognostic prolongation effect of reduction surgery for asymptomatic stage IV gastric cancer (GC) is unfavorable; however, its symptomatic GC remains unclear. We aimed to compare the prognosis gastrectomy and gastrojejunostomy GC.This multicenter retrospective study analyzed record-based data patients undergoing palliative in middle or lower-third regions between January 2015 December 2019. Patients were divided into distal groups. compared clinicopathological features outcomes after...
<i>Introduction:</i> It is difficult to confirm the location of an intraluminal gastrointestinal stromal tumor (GIST) and laparoscopically determine appropriate resection line. We report a new technique for GISTs using laparoscopic seromuscular dissection (LSD) technique, which can be preformed regardless location. <i>Methods:</i> Since 2009, 5 patients have undergone LSD GIST. The was confirmed endoscopically, exact line marked laparoscopically. After 10% glycerin...
Acute starvation, which is frequently observed in clinical practice, sometimes augments the cytolytic activity of natural killer cells against neoplastic cells. In this study, we investigated molecular mechanisms underlying enhancement cell function by fasting mice. The total number liver resident a unit weight tissue obtained from C57BL/6J mice did not change after 3-day fast, while proportions tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)+ and CD69+ were significantly...
Neurofibromas are a characteristic of the autosomal dominant disorder Neurofibromatosis type 1 (NF1), also known as von Recklinghausen's disease. Appendiceal neurofibromas extremely rare, and low-grade appendiceal mucinous neoplasms (LAMNs) have not previously been reported in NF1. A 62-year-old man with NF1 was scheduled for elective surgical treatment an asymptomatic, enlarged diffusely thickened appendix that remained after curative antimicrobial acute appendicitis. Laboratory analysis...
Perforating appendicitis and abscess-forming may cause septic disseminated intravascular coagulation (DIC). However, non-perforating acute with DIC is extremely rare.A 67-year-old man was referred to our hospital one day after starting oral antibiotic treatment for appendicitis. Physical examination revealed only slight spontaneous abdominal pain without tenderness peritoneal irritation. Contrast-enhanced computed tomography demonstrated an enlarged appendix (10 mm in diameter) fecalith,...
会陰ヘルニアは，ほとんどが腹会陰式直腸切断術あるいは骨盤内臓全摘術後に発生する続発性会陰ヘルニアである．今回，われわれは腹会陰式直腸切断術後に発生した続発性会陰ヘルニアの1例を経験したので報告する．症例は67歳，男性．直腸癌（Rb，MPN1M0，cStage IIIa）に対し術前化学放射線療法を施行後，両側側方リンパ節郭清を伴う腹会陰式直腸切断術を施行した．術後経過は良好であったが，術後12カ月後頃より会陰部の膨隆が出現した．次第に膨隆は増大傾向し，術後18カ月目の腹部造影CT検査においても会陰部の小腸の脱出を認め，続発性会陰ヘルニアと診断した．術後21カ月目，経腹的にヘルニア修復術を施行した．術中所見として，骨盤底に約10cm大のヘルニア門を認めた．ヘルニア門を覆うようにComposix® mesh （15.2cm×20.3cm）を骨盤底に固定し，骨盤底再建術を施行した．
Background: This study aimed to determine the safety and effectiveness of laparoscopy-assisted distal gastrectomy (LADG) after ESD. Methods: We reviewed patients with gastric cancer who underwent non-curative ESD from May 2000 July 2010, classified them into LADG-ESD open (ODG) (ODG-ESD). In addition, we analyzed standard LADG (LADG-standard) during same period. retrospectively surgical outcomes survival in these 3 groups. Pathological results were compared between ODG-ESD; Results:...