A5025358676- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Hernia repair and management
- Immune Cell Function and Interaction
- Gastrointestinal disorders and treatments
- Frailty in Older Adults
- Inflammatory Biomarkers in Disease Prognosis
- Genetic factors in colorectal cancer
- Abdominal vascular conditions and treatments
- Abdominal Surgery and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Abdominal Trauma and Injuries
- Colorectal Cancer Surgical Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Congenital Diaphragmatic Hernia Studies
Hiroshima Prefectural Hospital
2016-2025
Onomichi General Hospital
2016-2023
Hiroshima University
2010-2018
Creative Research Enterprises (United States)
2016
Chugoku Rosai Hospital
2010
Higashihiroshima Medical Center
2006
CD24 is a heavily glycosylated cell surface protein that expressed in putative stem cells and overexpressed various human malignancies, yet the significant roles of gastric cancer development are still elusive. We investigated involvement aggressiveness, which attributed to its heterogeneity. Cultured showed diverse expression patterns CD24, whereas other defined markers, such as CD44 CD133, were homogenous. Purely sorted CD24-negative strong alteration into CD24-positive type an...
Grade B or C post-pancreatectomy acute pancreatitis (PPAP) is associated with a higher incidence of postoperative complications and mortality. The reason for this the activation proteolytic processes that can lead to pancreatic destruction systemic reactions have adverse consequences such as inflammatory response syndrome, sepsis, death. We report case patient PPAP walled-off necrosis (WON) who was successfully treated necrosectomy using step-up approach. A 73-year-old man referred our...
Signet ring cell carcinoma (SRC) of the gallbladder is a rare type cancer. We report case SRC that was characterized by diffuse presence on mucosa and diagnosed after cholecystectomy. A 40-year-old man referred to our department with upper abdominal pain vomiting. Based findings blood tests, computed tomography, magnetic resonance imaging, acute cholecystitis suspected, emergency laparoscopic cholecystectomy performed. Intraoperative showed mild inflammation. Although tumor remained within...
To assess the safety of enhanced recovery after surgery (ERAS) program in gastrectomy and influences on nutrition state insulin-resistance.Our ERAS involved shortening fasting periods preoperative carbohydrate loading. Eighty patients were randomly assigned to either conventional group (CG) or (EG). We assessed clinical characteristics postoperative outcomes prospectively. The primary endpoint was noninferiority timely discharge from hospital within 12 d. Secondary endpoints incidence...
Formation of a liver abscess due to gastrointestinal perforation by foreign body is rare. In addition, there are few case reports on laparoscopic surgical treatment caused the tract body. A 51-year-old man visited our hospital because fever and anorexia. There were no physical findings except for fever. He had comorbidities or history. Laboratory tests showed increased inflammatory marker enzyme levels. Abdominal ultrasonography hypoechoic lesion in left lobe liver. contrast-enhanced...
Hepatoid adenocarcinoma of the stomach (HAS) is a rare and aggressive subtype gastric cancer (GC), accounting for less than 1% all cases. It characterized by frequent liver metastasis recurrence poorer prognosis conventional GC. However, established treatment guidelines HAS are currently not available.In this report, we present results clinicopathological study 19 patients diagnosed with HAS, including seven metastasis, conducted Hiroshima Surgical Study Group Clinical Oncology (HiSCO)...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of gastrointestinal tract. The tumor size and mitotic count, typical risk category factors, difficult to determine preoperatively. This study aimed evaluate usefulness preoperative 18F-fluoro-2-deoxyglucose positron-emission tomography/computed tomography (18FDG-PET/CT) for predicting malignant potential GISTs by analyzing correlation between maximum standardized uptake value (SUVmax) postoperative factors.Thirty...
Gallbladder torsion is mainly associated with a floating gallbladder. From an anatomical perspective, laparoscopic cholecystectomy more optimal treatment than open cholecystectomy.An 84-year-old woman visited the Onomichi General Hospital because of progressive pain in right upper quadrant her abdomen. Physical examination revealed positive Murphy sign and peritoneal irritation. Laboratory data demonstrated that inflammatory marker levels were increased. Abdominal ultrasonography showed...
Complete spontaneous necrosis of hepatocellular carcinoma (HCC) without any pretreatment or angiography is rare. We present a rare case complete HCC, as confirmed after hepatectomy. The patient, 74-year-old man with history alcoholic hepatitis, was referred to our hospital for confirmation suspected HCC. In March 2015, abdominal ultrasonography detected low echoic mass in segment 8 (S8) the liver. Contrast-enhanced computed tomography (CT) imaging revealed interval growth this tumor and...
Abstract Background Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. Therefore, identifying predictive factors for surgical morbidity, disease recurrence, and long-term survival necessary preventing GC patient mortality. We aimed to evaluate that contribute poor prognoses patients. Methods In this retrospective cohort study, data 182 patients who underwent curative gastrectomy was reviewed. The included patients’ stage preoperative prognostic nutritional...
Percutaneous radiofrequency ablation (RFA) is widely used as an effective treatment of liver tumors. Several reported complications associated with RFA are due to thermal damage neighboring organs. The present report presents a case diaphragmatic hernia and hepatocellular carcinoma (HCC). A 72-year-old woman S5 S8 HCCs was treated repeatedly transcatheter arterial chemoembolization for 3 years. After the third course target recurring HCC, acute abdominal pain dyspnea suddenly occurred....
Although duodenal perforation is currently an infrequent complication of medical procedures, its incidence in the future predictably will increase as endoscopic treatment neoplasms becomes more frequently used. In some cases, difficult to treat even surgically. We report here a novel technique called 'triple-tube-ostomy' for iatrogenic perforation. Since November 2009, there have been three cases duodenum, due various causes, which we treated with our technique. The main principles are...
Abstract Background Preoperative diagnosis of gallbladder amyloidosis is usually difficult. In our case, the patient exhibited dyskinesia, which led us to suspect cholecystic amyloidosis. We were able safely perform surgery before cholecystitis onset. Case presentation A 59-year-old male with a history multiple myeloma and cardiac presented hospital chief complaint epicardial pain. Abdominal ultrasonography computed tomography revealed an enlarged biliary sludge without any specific imaging...
The prognostic prolongation effect of reduction surgery for asymptomatic stage IV gastric cancer (GC) is unfavorable; however, its symptomatic GC remains unclear. We aimed to compare the prognosis gastrectomy and gastrojejunostomy GC.This multicenter retrospective study analyzed record-based data patients undergoing palliative in middle or lower-third regions between January 2015 December 2019. Patients were divided into distal groups. compared clinicopathological features outcomes after...
Laparoscopic and endoscopic cooperative surgery (LECS) is a minimally invasive hybrid procedure that facilitates the precise dissection of gastrointestinal malignancies. We report use LECS as palliative treatment for patient with advanced gastric cancer at high risk due to comorbidities.A 68-year-old woman general malaise was admitted hospital received multiple transfusions anemia. Endoscopy examination detected an ulcerative lesion in stomach. She comorbidities including liver cirrhosis...
Although many anticancer agents for gastric cancer have been developed, the prognosis patients remains poor. Recently, costimulatory immune molecules that reactivate antitumor responses by utilizing host system attracted attention as new therapeutic strategies. CD137 is a molecule reportedly potentiates activity of tumor-targeting monoclonal antibodies (mAbs) enhancing antibody-dependent cellular cytotoxicity. However, it unclear whether stimulates tumor-regulatory in cancer. In this study,...
Acute starvation, which is frequently observed in clinical practice, sometimes augments the cytolytic activity of natural killer cells against neoplastic cells. In this study, we investigated molecular mechanisms underlying enhancement cell function by fasting mice. The total number liver resident a unit weight tissue obtained from C57BL/6J mice did not change after 3-day fast, while proportions tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)+ and CD69+ were significantly...
Morgagni's or Larrey's diaphragmatic hernias are relatively uncommon. If the defect is too large for primary closure, use of a mesh inevitable. Although closure adaptable small defects, it difficult to suture hernial orifice in which anterior rim absent. Herein, we present case patient with hernia that was easily and securely repaired using recently developed laparoscopic extra-abdominal suturing technique via port needle (Endo Close®; Medtronic, Minneapolis, USA).An 89-year-old woman...
Visceral artery aneurysms at the origin of gastric and gastroepiploic are uncommon. Raptured visceral cause high mortality require urgent adequate intervention treatment.A 65-year-old woman was transferred to emergency department with sudden abdominal back pain. Radiographically, we diagnosed intra-abdominal bleeding due a ruptured aneurysm right artery. Although her vital signs were relatively stable, transcatheter arterial embolization (TAE) could not be performed thrombotic occlusion...
Gastric carcinosarcoma with severe venous invasion is extremely rare, and to the best of our knowledge, this first reported case.A 79-year-old man visited Onomichi General Hospital following abnormal upper gastrointestinal series findings. Laboratory data demonstrated no anemia, serum carcinoembryonic antigen (CEA) carbohydrate 19-9 (CA19-9) levels were not elevated. Endoscopy identified a Borrmann type III lesion in cardiac end stomach. Abdominal contrast-enhanced computerized tomography...
Duodenal carcinoma originating in Brunner's gland is rare. Herein, we report a case of duodenal arising from 63-year-old man.On diagnostic imaging, the lesion presented as non-invasive carcinoma; patient also had uncontrolled diabetes and liver cirrhosis. Hence, decided to perform partial duodenectomy reduce operative stress. Pathological examination revealed that tumor consisted tissue gland. Additionally, cells were strongly positive for Mucin-6 protein, which an epithelial marker The...