A5085405229- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroblastoma Research and Treatments
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal disorders and treatments
- Neuropeptides and Animal Physiology
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Pancreatic function and diabetes
- Gallbladder and Bile Duct Disorders
- Diabetes and associated disorders
- Pituitary Gland Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Congenital Heart Disease Studies
- Phagocytosis and Immune Regulation
- Diabetes Management and Research
- Receptor Mechanisms and Signaling
- Genetic factors in colorectal cancer
- Gestational Trophoblastic Disease Studies
- Hepatocellular Carcinoma Treatment and Prognosis
Fukuoka International University
2017-2024
International University of Health and Welfare
2017-2024
Sanno Medical Center
2019-2024
Sapporo Higashi Tokushukai Hospital
2024
Kyushu University
2011-2022
The Japanese Society of Gastroenterological Surgery
2016-2022
Japan Cancer Society
2018-2022
Nagoya City University
2021
Mizuho (Japan)
2021
Fukuoka Kinen Hospital
2020
Everolimus, an oral inhibitor of mammalian target rapamycin (mTOR), has shown antitumor activity in patients with advanced pancreatic neuroendocrine tumors, two phase 2 studies. We evaluated the agent a prospective, randomized, 3 study.
Journal Article Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 Get access Hisanori Umehara, Umehara Department of Hematology and Immunology, Kanazawa Medical University, Kanazawa, JapanDivision Internal Medicine, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan Correspondence to: Kazuichi Okazaki, e-mail: umehara@kanazawa-med.ac.jp Search other works by this author on: Oxford Academic Google Scholar Okazaki Division Gastroenterology Hepatology,...
IgG4-related disease (IgG4-RD) is a novel clinical entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration IgG4+ plasma cells. Although IgG4-RD not rare clinically important, its diagnostic criteria have been established. Comprehensive for IgG4-RD, including the involvement of various organs, are intended practical use general physicians nonspecialists. Background: Methods: Two study groups, Umehara Okazaki teams, were organized Ministry Health, Labor...
atic duct and diffuse enlargement of the entire pancreas due to lymphocyte infiltration.In 1995, Japanese investigators 3 firstly proposed a concept "autoimmune pancreatitis (AIP)", in which patients showed diffusely enlarged pancreas, narrowing pancreatogram, increased serum IgG, presence autoantibodies, fibrotic changes with lymphocytic infiltration steroidal efficacy.Thereafter, many AIP cases have been reported from Japan, has accepted as new clinical entity. 4,5The histopathological...
New epidemiological data come from a study performed in Argentina [2] , showing that g-NENs and d-NENs represent 6.9 2.0% of all digestive NENs, respectively.These are similar to the SEER data, where were found 8.7% enteric NENs [3] quite recent prospective Austrian by Niederle et al. [4] represented 5.6% NENs.The proportions with respect overall NEN rates do vary, however; 23% compared 6% 5% Canadian (Ontario) 7.4% Taiwanese [4][5][6][7] .These differences underline need for multicenter...
Multiple endocrine neoplasia type 1 (MEN1) is classically characterized by the development of functional or nonfunctional hyperplasia tumors in tissues (parathyroid, pancreas, pituitary, adrenal). Because effective treatments have been developed for hormone excess state, which was a major cause death these patients past, coupled with recognition that nonendocrine increasingly develop late disease course, natural history has changed. An understanding current causes important to tailor...
Corticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but requirement maintenance corticosteroid is controversial. We conducted a randomised controlled trial to clarify efficacy of in patients with AIP.We multicentre, tertiary setting, trial. After induction remission initial oral prednisolone (PSL) treatment, PSL at 5-7.5 mg/day was continued 3 years or withdrawn 26 weeks. The primary endpoint relapse-free survival over and secondary serious...
Purpose: Patients with pancreatic neuroendocrine neoplasm grade-3 (PanNEN-G3) show variable responses to platinum-based chemotherapy. Recent studies indicated that PanNEN-G3 includes well-differentiated tumor G3 (NET-G3). Here, we examined the clinicopathologic and molecular features of assessed responsiveness chemotherapy survival.Experimental Design: A total 100 patients were collected from 31 institutions, after central review characteristics each histologic subtype [NET-G3 vs. carcinoma...
Abstract Neuroendocrine neoplasms (NENs) are rare that occur in various organs and present with diverse clinical manifestations. Pathological classification is important the diagnosis of NENs. Treatment strategies must be selected according to status differentiation malignancy by accurately determining whether neoplasm functioning or nonfunctioning, degree disease progression, presence metastasis. The newly revised Clinical Practice Guidelines for Gastroenteropancreatic Neoplasms (GEP-NENs)...
As the patients with autoimmune pancreatitis (AIP) are increasing in Japan, practical guideline for managing AIP is required to be established.Three committees (the professional committee making clinical questions [CQs] and statements by Japanese specialists, expert panelist rating modified Delphi method, evaluating moderators) were organized. Fifteen specialists extracted specific from a total of 871 literatures PubMed search (approximately 1963-2008) secondary database made CQs statements....
Multiple endocrine neoplasia type 1 (MEN1) patients frequently develop Zollinger-Ellison syndrome (ZES). These can proliferative changes of gastric enterochromaffin-like (ECL) cells and carcinoids (ECL-cell tumors). ECL-cell have been extensively studied in sporadic ZES be precursor lesions carcinoids, but little is known about factors influencing their severity or development MEN1/ZES patients.Our objective was to prospectively analyze tumors) a large series detect risk deduct clinical...