A5025133766- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Pancreatic function and diabetes
- Pregnancy and Medication Impact
- Cardiac Arrhythmias and Treatments
- Pregnancy and preeclampsia studies
- Receptor Mechanisms and Signaling
- Central Venous Catheters and Hemodialysis
- Metabolism, Diabetes, and Cancer
- Parasitic Diseases Research and Treatment
- Renal and Vascular Pathologies
- Diabetes Treatment and Management
- X-ray Diffraction in Crystallography
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Pharmacological Effects and Toxicity Studies
- Genetic and Kidney Cyst Diseases
- Erythropoietin and Anemia Treatment
- Viral Infections and Immunology Research
- Cardiovascular Disease and Adiposity
- Parathyroid Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Orthopedic Surgery and Rehabilitation
Chiba University
2025
Nagasaki Medical Center
2024-2025
Nagasaki University Hospital
2016-2024
Kyocera (Japan)
2024
Takeda (Japan)
2019-2021
St. Luke's International Hospital
2021
Sasebo City General Hospital
2020
Nagasaki University
2013-2019
Jikei University School of Medicine
2014
Sumitomo Chemical (Japan)
2007-2008
Abstract Neuroendocrine neoplasms (NENs) are rare that occur in various organs and present with diverse clinical manifestations. Pathological classification is important the diagnosis of NENs. Treatment strategies must be selected according to status differentiation malignancy by accurately determining whether neoplasm functioning or nonfunctioning, degree disease progression, presence metastasis. The newly revised Clinical Practice Guidelines for Gastroenteropancreatic Neoplasms (GEP-NENs)...
Abstract Circulating phosphate levels are tightly controlled within a narrow range in mammals. By using novel small-molecule inhibitor, we show that the enzymatic activity of inositol hexakisphosphate kinases (IP6K) is essential for regulation vivo. IP6K inhibition suppressed XPR1 , exporter, thereby decreasing cellular export, which resulted increased intracellular ATP levels. The vivo decreased plasma without inhibiting gut intake or kidney reuptake phosphate, demonstrating pivotal role...
The GPR40/FFA1 receptor is a G-protein-coupled expressed in the pancreatic islets and enteroendocrine cells. Here, we report pharmacological profiles of (3S)-3-cyclopropyl-3-{2-[(1-{2-[(2,2-dimethylpropyl)(6-methylpyridin-2-yl)carbamoyl]-5-methoxyphenyl}piperidin-4-yl)methoxy]pyridin-4-yl}propanoic acid (SCO-267), novel full agonist GPR40. Ca2+ signaling insulin glucagon-like peptide-1 (GLP-1) secretion were evaluated GPR40-expressing CHO, MIN6, GLUTag Hormone secretions effects on fasting...
To evaluate the significance of tubulointerstitial lesions in cortical area renal biopsy specimens, clinicopathological studies were performed on 101 cases IgA nephropathy, 31 IgA-negative (non-IgA) proliferative glomerulonephritis and 75 idiopathic membranous glomerulonephritis. The degree was assessed semiquantitatively by light microscopic observation correlated with several histopathological clinical parameters at biopsy, as well status final follow-up (average period: 72 months). In...
A 78-year-old male was admitted to the hospital with acute renal failure and generalized erythema after starting dapagliflozin 10 mg/day for chronic kidney disease (CKD). skin biopsy revealed superficial perivascular dermatitis eosinophils. lymphocytic eosinophilic infiltration of interstitium, focal tubulitis. The patient diagnosed a dapagliflozin-induced drug reaction eosinophilia systemic symptoms (DRESS), followed by interstitial nephritis (AIN), prednisolone therapy therefore initiated....
Usefulness of the Glasgow prognostic score (GPS), modified GPS (mGPS), and high-sensitivity mGPS (HS-mGPS) in prognosis patients undergoing hemodialysis remains unclear. This study aimed to investigate this. The GPS, mGPS, HS-mGPS were calculated retrospectively 339 hemodialysis; their association with all-cause mortality was analyzed using Kaplan-Meier method Cox proportional hazards models. Survival rates decreased according (0, 1, 2), but similar between HS-mGPS. In multivariate model,...
Arsenite [As(III)] is a toxic substance widely present on Earth, and the development of low-cost simple microbial-based As(III) sensors has been attracting attention. Recently, we discovered that protein LuxR, which contains multiple cysteine residues with high affinity for As(III), forms an insoluble structure upon binding to exhibits OFF-switching properties as quorum sensing transcriptional activator. Based this property, LuxR sensor operates new principle distinct from conventional...
GPR40/FFAR1 is a Gq protein-coupled receptor expressed in pancreatic β cells and enteroendocrine cells, mediates insulin incretin secretion to regulate feeding behavior. Several GPR40 full agonists have been reported reduce food intake rodents by regulating gut hormone addition their potent glucose-lowering effects; however, detailed mechanisms of suppression are still unknown. In the present study, we characterized T-3601386, novel compound with agonistic activity for GPR40, using vitro...
Exposure to ethanol during development induces severe brain damage, resulting in a number of CNS dysfunctions including microencephaly and mental retardation. Potential targets ethanol-induced neurotoxicity include neurotrophic factors their signal transduction pathways. In the present study, rat pups were given at dose 5 g kg(-1) via gavage from postnatal day (PND) 8, mRNA expression nerve growth-factor (NGF), brain-derived factor (BDNF), factor-3 (NT-3) cerebral cortex was examined, with...
We undertook an optimization effort involving propan-2-yl 4-({6-[5-(methanesulfonyl)-2,3-dihydro-1H-indol-1-yl]pyrimidin-4-yl}oxy)piperidine-1-carboxylate 1, which we had previously discovered as a novel G protein-coupled receptor 119 (GPR119) agonist. To occupy presumed hydrophobic space between the pyrimidine and piperidine rings in interaction with GPR119, replaced linker oxygen nitrogen. Subsequently, introduction of substituent at bridging nitrogen atom was explored. found that...
BACKGROUND Endocan is expressed in vascular endothelial cells, and its expression enhanced following injury via inflammatory cytokines. Subsequently, endocan secreted into the circulation. Thus, serum levels are considered a marker of injury. However, to best our knowledge, no data on peritoneal dialysis (PD) patients available. MATERIAL AND METHODS This study included 21 PD who underwent equilibration test (PET) more than once between 2011 2015. Serum samples were collected from each...
Although histone acetylation, an epigenetic modification, has been reported to be related the progression of various diseases, its involvement in nephrosclerosis is unclear. Dahl salt-sensitive rats were used as a model this study. The divided into three groups: (i) normal-salt diet group, (ii) high-salt group (HS), and (iii) HS administered daily with curcumin, acetyltransferase inhibitor (HS+C). At 6 weeks after treatment, kidneys dissected. Morphologic changes assessed by Masson's...
A percutaneous renal biopsy is an essential tool for the diagnosis of various diseases; however, post-biopsy bleeding a major complication. Hemocoagulase detoxified and purified snake venom enzyme that widely used to prevent post-procedural bleeding. In this study, we retrospectively analyzed effect hemocoagulase on post-renal We included 221 patients who underwent between April 2017 December 2020 hemoglobin (Hb) decline in were administered periprocedural injection. After biopsy, mean Hb...
Leptin is a hormone mainly produced by white adipose cells, and regulates body fat food intake acting on hypothalamus. receptor expressed not only in the hypothalamus but variety of peripheral tissues, suggesting that leptin has pleiotropic functions. In this study, we investigated effect progression peritoneal fibrosis induced intraperitoneal injection chlorhexidine gluconate (CG) every other day for 2 or 3 weeks mice. This study was conducted male C57BL/6 mice leptin-deficient ob/ob...
Long-term peritoneal dialysis therapy causes inflammation and histological changes in the membrane. Inflammation generally activates fibroblasts results fibroblast–myofibroblast differentiation. Heat-shock protein 47 (HSP 47), a collagen-specific molecular chaperone, is localized myofibroblasts involved progression of fibrosis. Daikenchuto (DKT), Kampo medicine, used to prevent postoperative colon adhesion. It inhibits HSP expression gastrointestinal tract. We examined effect DKT on...
Abstract Candida peritonitis is a crucial disease, however the optimal antifungal therapy regimen has not been clearly defined. Peritoneal fibrosis (PF) can be caused by abdominal surgery, intra-abdominal infection, and malignant diseases, also widely recognized as complication of long-term peritoneal dialysis. However, influence PF on prognosis remains unknown. Here, we evaluated severity within context efficacy micafungin using mice. A mouse model was generated intraperitoneally...