A5043025704- Pain Mechanisms and Treatments
- Trigeminal Neuralgia and Treatments
- Salivary Gland Disorders and Functions
- Botulinum Toxin and Related Neurological Disorders
- Pancreatic and Hepatic Oncology Research
- Olfactory and Sensory Function Studies
- Dental Anxiety and Anesthesia Techniques
- Pancreatitis Pathology and Treatment
- Myofascial pain diagnosis and treatment
- Migraine and Headache Studies
- Neuropeptides and Animal Physiology
- Temporomandibular Joint Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gastrointestinal disorders and treatments
- Anesthesia and Sedative Agents
- Facial Nerve Paralysis Treatment and Research
- Sexual function and dysfunction studies
- Pain Management and Placebo Effect
- Liver Disease Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Spine and Intervertebral Disc Pathology
- Oropharyngeal Anatomy and Pathologies
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Acupuncture Treatment Research Studies
Ehime University
2016-2025
Ehime University Hospital
2023-2024
Nihon University
2014-2023
Weatherford College
2021
Saiseikai Matsuyama Hospital
2017
University of Dental Medicine
2009
Surugadai Nihon University Hospital
2006
Kyushu Dental University
1987-2003
National Institute of Dental and Craniofacial Research
1995
National Institutes of Health
1995
The aim of this study was to investigate whether astroglia in the medullary dorsal horn (trigeminal spinal subnucleus caudalis; Vc) may be involved orofacial neuropathic pain following trigeminal nerve injury. effects intrathecal administration astroglial aconitase inhibitor sodium fluoroacetate (FA) were tested on Vc hyperactivity [as revealed by glial fibrillary acid protein (GFAP) labeling], nocifensive behavior, extracellular signal-regulated kinase phosphorylation (pERK), and neuronal...
Abstract Aim Portal hypertension resulting from liver cirrhosis (LC) can lead to pancreatic congestion and impaired insulin secretion. Therefore, this prospective study aimed assess the association between exocrine function in patients with LC. Methods In our clinical study, were evaluated using shear wave dispersion (SWD) fecal elastase‐1 (FE‐1). Additionally, acinar cells, venous walls, fibrosis assessed an autopsy study. Results The FE‐1 levels lower LC group ( n = 41) than control (312 ±...
This study aimed to evaluate the usefulness of light-cured resin coating restoration materials (RCs) on anterior composite blocks by quantifying color, gloss, and surface roughness before after toothbrush abrasion test shear bond strength thermal cycling test. Four types RCs were used in experiments. The application resulted color changes a decrease gloss test; however, both within clinically acceptable limits. was at value that made bacterial adhesion difficult also had strength. Therefore,...
Fractalkine (FKN) signaling is involved in mechanical allodynia the facial skin following trapezius muscle inflammation. Complete Freund's adjuvant (CFA) injection into produced ipsilateral that was not associated with inflammation and resulted FKN but receptor (CX3CR1) expression, microglial activation enhanced trigeminal spinal subnucleus caudalis (Vc) upper cervical cord (C1–C2). Intra-cisterna magna anti-CX3CR1 or anti-interleukin (IL)-1β neutralizing antibody administration decreased...
Diffusion imaging is a unique noninvasive tool to detect brain white matter trajectory and integrity in vivo. However, this technique suffers from spatial distortion signal pileup or dropout originating local susceptibility gradients eddy currents. Although there are several methods mitigate these problems, most techniques can be applicable either eddy-current induced alone with few exceptions. The present study compared the correction efficiency of FSL tools, "eddy_correct" combination...
Trigeminal nerve injury causes a distinct time window of glial activation in the trigeminal spinal subnucleus caudalis (Vc), which are involved initiation and maintenance phases orofacial neuropathic pain. Microglia-derived factors enable astrocytes. The complement component C1q, promotes astrocytes, is known to be synthesized microglia. However, it unclear whether microglia–astrocyte communication via C1q Here, we analyzed microglia-astrocyte rat model with infraorbital (IONI). mechanical...
Abstract Objective To develop a beta version of preliminary set empirically derived research diagnostic criteria (RDC) for burning mouth syndrome (BMS) through expert consensus, which can then be taken into test period before publication final RDC/BMS. Design A 6 round Delphi process with twelve experts in the field BMS was used. The first formed focus group during purpose RDC and definition agreed upon, as well structure contents. remaining rounds were carried out virtually via email to...
Research suggests that varied etiologic factors are responsible for burning mouth syndrome (BMS). We examined the role of immune and endocrine function in pathology BMS.We conducted a case-control study to evaluate (lymphocyte subpopulations) (hypothalamus-pituitary-adrenal axis sympathetic-adrenomedullary system) 47 female BMS patients age-matched controls presenting at an university clinic. Psychological state was assessed with Zung Self-Rating Depression Scale Taylor Manifest Anxiety...
Burning mouth syndrome (BMS) is an idiopathic orofacial pain condition. Although the pathophysiology of BMS not clearly understood, central and peripheral neuropathic mechanisms are thought to be involved. The authors compared brain response noxious heat stimuli in 16 right-handed women with primary 15 sex- age-matched healthy female controls. A thermal stimulus sequence 32 °C 40 49 was repeated 4 times a cycle. Warm were delivered Peltier thermode placed on right palm or lower lip for s...
Background: The aim of this study is to clarify the neural mechanisms underlying orofacial pain abnormalities after cervical spinal nerve injury. Nocifensive behavior, phosphorylated extracellular signal-regulated kinase (pERK) expression and astroglial cell activation in trigeminal subnucleus caudalis (Vc) upper dorsal horn (C1-C2) neurons were analyzed rats with transection (CNX). Results: head withdrawal threshold mechanical stimulation lateral facial skin latency heating significantly...
The exact mechanism underlying chronic masseter muscle pain, a conspicuous symptom in temporomandibular disorder, remains unclear. We investigated whether expression of P2X3 receptor (P2X3R) is involved mechanical hyperalgesia after contraction (CMM). As compared with sham rats, the head-withdrawal threshold (HWT) to pressure stimulation (MM) (but not similar facial skin) was significantly lower, and IL-1β level higher, CMM rats on day 7 CMM. mean percentage FG-labeled P2X3R-positive neurons...
We report a case of temporal arteritis with sympathetic component in the orofacial region, which responded to stellate ganglion blocks (SGBs).An 81-year-old woman limited mouth opening and pain upon chewing was referred Orofacial Pain Clinic at Nihon University Dental Hospital. The patient also presented blurred vision burning sensation on right side her face. On clinical examination, artery tender palpation, there increased sensitivity region bilaterally. reported jaw opening. Laboratory...