A5072903988- Pain Mechanisms and Treatments
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Pain Management and Placebo Effect
- Pediatric Pain Management Techniques
- Musculoskeletal pain and rehabilitation
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Acupuncture Treatment Research Studies
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Dental Anxiety and Anesthesia Techniques
- Veterinary Pharmacology and Anesthesia
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychosomatic Disorders and Their Treatments
- Heart Rate Variability and Autonomic Control
- Traditional Chinese Medicine Studies
- Oral health in cancer treatment
- Education Systems and Policy
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroscience and Neural Engineering
- Pain Management and Treatment
- Stress Responses and Cortisol
- Forecasting Techniques and Applications
- Nausea and vomiting management
Penn Center for AIDS Research
2025
University of Pennsylvania Health System
2025
University of Oxford
2020-2023
University of Utah
2010-2021
University of Hawaiʻi at Mānoa
2020
University of Glasgow
2013-2014
Rutherford Appleton Laboratory
2011-2013
University of Manchester
2010-2012
University of Calgary
2012
University of Washington
1992-2001
The practice and theoretical basis of pain measurement is reviewed critically examined in the areas animal research, human subjects laboratory investigation clinical study. advantages limitations both physiological behavioral methods are discussed each area, subjective report procedures evaluated areas. need for that bridge these emphasized specific issues identified. Progress technology over recent decades directions future work suggested.
Improving regulated medical waste (RMW) management is crucial for enhancing planetary health and cost savings. We sought to assess an educational intervention on clinical staff understanding behavior regarding RMW management. This two-month (2023-2024) controlled, prospective at the University of Pennsylvania Health System surveyed healthcare workers, including physicians, nurses, assistants, from four inpatient medicine floors two dermatology clinics. Half settings were controls. The...
Pain is a complex, multidimensional perception with affective as well sensory features. In part, it somatically focused negative emotion resembling perceived threat. Suffering refers to threat the integrity of self, helplessness in face that threat, and exhaustion psychosocial personal resources for coping. The concepts pain suffering therefore share common ground. Examination central physiological mechanisms underlying pain, emotional arousal, stress helps clarify basis causal influences...
Abstract Background About 240 million patients undergo surgery every year, worldwide. Roughly 50% of these report clinically significant pain. Numerous barriers impede provision adequate management. Lack evidence about appropriateness and effectiveness interventions is one. A registry can provide such information, eventually facilitating better This paper reports the development feasibility PAIN OUT , first international acute pain registry, established with funds from E uropean C ommission,...
Pupillary response to noxious stimulation was investigated in men ( n = 11) and women 9). Subjects experienced repeated trials of electrical fingertip at four intensities, ranging from faint barely tolerable pain. Measures included pupil dilation (PDR), pain report (PR), brain evoked potentials (EPs). The PDR began 0.33 s peaked 1.25 after the stimulus. Multivariate mixed‐effects analyses revealed that (a) increased significantly peak amplitude as stimulus intensity increased, (b) EP peaks...
The effect of 80 min low frequency (2 Hz) electric acupuncture stimulation at facial sites on the perception induced dental pain was evaluated using both threshold and sensory decision theory (SDT) procedures. demonstration a 187% increase in over 20 period acupunctural replicated earlier work by Swedish investigators. SDT analyses indicated that reflected relatively pure change with no significant modification response bias. However, subjects were able to perceive some stimuli presented...
Propofol and alfentanil frequently are administered together for intravenous sedation. This study investigated pharmacokinetic pharmacodynamic interactions between propofol alfentanil, at sedative concentrations, with specific regard to effects on ventilation, analgesia, sedation, nausea.Ten male volunteers underwent steady-state infusions 3 separate days consisting of alone, or a combination the two. Target plasma concentrations were 150, 300, 600 ng/ml 1 h each concentration; it was 40 h....
We used computer-controlled individually tailored infusions to study relationships between plasma drug concentration and opioid effects, evaluate the therapeutic margins of alfentanil, fentanyl morphine in human subjects. In order compare 3 drugs, we infused each different steady-state target concentrations during separate 8 h test periods so that concentration-effect curves could be defined for subject. Dental electrical stimulation produced a consistent degree baseline experimental pain,...
The technology for patient intravenous self-administration of morphine has been successfully implemented in postoperative and other clinical settings can be used with terminal patients who experience pain. question whether use such instrumentation will vulnerable to over-medication or development addiction not addressed. This report reviews two competing theories that bear upon this tests their predictions about pain relief using data obtained from a bone marrow transplant unit. first,...
Pain threshold for electrical stimulation of healthy, unfilled teeth was studied in young and elderly women. Using the methodology Sensory Decision Theory, ability to discriminate between suprathreshold shocks (d') response bias were also assessed. No difference observed groups. The women poorer at discriminating than These results interpreted reflect integrity high-threshold dental pulp afferents a central nervous system deficit on part such shocks. Significant age differences observed....
Radiant heat stimulation was applied to volunteers and rating scale responses were obtained assess the analgesic properties of 33 percent nitrous oxide. The methodology signal detection theory data demonstrate that oxide reduces both sensitivity pain willingness report pain. This method is superior threshold estimation for evaluation analgesics.