A5070537948- Dementia and Cognitive Impairment Research
- Music Therapy and Health
- Neuroscience and Music Perception
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Multisensory perception and integration
- Olfactory and Sensory Function Studies
- Cerebrovascular and genetic disorders
- Neurobiology of Language and Bilingualism
- Hearing Loss and Rehabilitation
- Cerebrovascular and Carotid Artery Diseases
- Diverse Music Education Insights
- Color perception and design
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- Optical Imaging and Spectroscopy Techniques
- Metalloenzymes and iron-sulfur proteins
- RNA regulation and disease
- Spatial Neglect and Hemispheric Dysfunction
- Moyamoya disease diagnosis and treatment
- Gait Recognition and Analysis
Advanced Institute of Industrial Technology
2019-2025
Mie University
2014-2023
Tokyo Metropolitan University
2019-2021
Ritsumeikan University
2019
Seikei University
2019
Kobe University
2019
Chukyo University
2019
Dementia UK
2016
Mie University Hospital
2016
Previous studies have shown that the perception of facial and vocal affective expressions interacts with each other. Facial usually dominate when we perceive emotions face-voice stimuli. In most these studies, participants were instructed to pay attention face or voice. Few compared perceived without specific instructions regarding modality which should be directed. Also, used combinations voice expresses two opposing emotions, limits generalizability findings. The purpose this study is...
To investigate the effect of singing training on cognitive function in Alzheimer's disease (AD) patients.Ten AD patients (mean age 78.1 years) participated music therapy using once a week for 6 months (music group). Each session was performed with professional musicians karaoke and unique voice method (the YUBA Method). Before after intervention period, each patient assessed by neuropsychological batteries, functional magnetic resonance imaging (fMRI) while sang familiar songs device. As...
While music triggers many physiological and psychological reactions, the underlying neural basis of perceived experienced emotions during listening remains poorly understood. Therefore, using functional magnetic resonance imaging (fMRI), I conducted a comparative study different brain areas involved in perceiving feeling listening. measured fMRI signals while participants assessed emotional expression (perceived emotion) their responses to (felt emotion). found that cortical including...
Findings from previous studies suggest that physical exercise combined with cognitive training produces more positive effects on function in elderly people than alone. However, the brain plasticity associated these proposed benefits of therapy has not yet been investigated subjects. We hypothesized dual task group would experience greater alone and non-exercise control groups regard to both plasticity. This study effect musical accompaniment structural changes healthy people. Fifty-one...
Burning mouth syndrome (BMS) is an idiopathic orofacial pain condition. Although the pathophysiology of BMS not clearly understood, central and peripheral neuropathic mechanisms are thought to be involved. The authors compared brain response noxious heat stimuli in 16 right-handed women with primary 15 sex- age-matched healthy female controls. A thermal stimulus sequence 32 °C 40 49 was repeated 4 times a cycle. Warm were delivered Peltier thermode placed on right palm or lower lip for s...
Abstract Catheter ablation is an important non-pharmacological intervention for atrial fibrillation (AF), but its effect on the incidence of asymptomatic cerebral emboli and long-term effects cognitive function remain unknown. We prospectively enrolled 101 patients who underwent AF ablation. Brain magnetic resonance imaging (MRI) (72 patients) neuropsychological assessments (66 were performed 1–3 days (baseline) 6 months after Immediately ablation, diffusion-weighted MRI 3-dimensional double...
Cerebral amyloid angiopathy (CAA) is classified as type 1 with capillary β (Aβ) or 2 without Aβ. While it known that CAA activates complement, an inflammatory mediator, there no information on the relationship between Aβ and complement activation.We evaluated 34 autopsy brains, including 22 12 other neurodegenerative diseases. We assessed vascular density of by analyzing expression (C1q, C3d, C6, C5b-9), macrophage scavenger receptor (MSR), apolipoprotein E (ApoE).Capillary immunostaining...
Background: Lobar microbleeds (MBs) and cortical microinfarct (CMI) are caused by cerebral amyloid angiopathy in the elderly increase number Alzheimer's disease. Objective: The aim of this study is to elucidate effects lobar MBs CMIs on cognitive function. Methods: subjects were outpatients who visited memory clinic Mie University Hospital. Among 120 subjects, 109 patients fulfilled inclusion criteria. We quantitatively estimated using double inversion recovery 3D FLAIR images 3T MRI....
Melodic intonation therapy (MIT) is a treatment program for the rehabilitation of aphasic patients with speech production disorders. We report case severe chronic non-fluent aphasia unresponsive to several years conventional that showed marked improvement following intensive nine-day training on Japanese version MIT (MIT-J). The purposes this study were verify efficacy MIT-J by functional assessment and examine associated changes in neural processing magnetic resonance imaging. improved...
Background and Purpose- Cortical microinfarcts (CMIs) are small ischemic lesions found in cerebral amyloid angiopathy (CAA) embolic stroke. This study aimed to differentiate CMIs caused by CAA from those microembolisms, using 3-Tesla magnetic resonance imaging. Methods- We retrospectively investigated 70 patients with at least 1 cortical infarct <10 mm on 3-dimensional double inversion recovery Of the patients, 43 had an stroke history (Emboli-G) while 27 CAA-group. compared size, number,...
Objectives Clinical characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) include migraine, recurrent stroke, white matter lesions, vascular dementia. CADASIL is one the most common hereditary small vessel diseases. presentation varies a racial gap may exist between Asian Caucasian populations. This first nationwide epidemiological survey which aimed to elucidate clinical features in Japan. Moreover, registration database was...
A 63-year-old, right-handed professional chorus conductor developed right putaminal hemorrhage, and became unable to experience emotion while listening music. Two years later, neurological examination revealed slight left hemiparesis. Neuromusicological assessments impaired judgment of “musical sense,” the inability discriminate sound chords in pure intervals from those equal temperament. Brain MRI tractography identified old hemorrhagic lesion putamen fiber connectivity between insula...
Abstract Introduction This study aims to investigate the association between presence and frequency of cortical lesions ( CL s), clinical psychological features multiple sclerosis MS ). Methods A total 19 patients with were examined using double inversion recovery DIR ) sequences 3T magnetic resonance imaging MRI classified into two groups: non‐ . In‐house software was used quantitatively determine atrophy each brain region. Activities daily living ADL estimated Kurtzke Expanded Disability...
Constructional apraxia (CA) is usually diagnosed by having patients draw figures; however, the reported assessments only evaluate drawn figure. We designed a new assessment battery for CA (the Mie Apraxia Scale, MCAS) which includes both shape and drawing process, investigated its utility against other methods.We MCAS, evaluated inter- intrarater reliability. also sensitivity, specificity, positive negative predictive values in dementia patients, compared MCAS with batteries same...
BACKGROUND: While several studies support an association of white matter hyperintensity (WMH) volume and regional cerebral blood flow (rCBF) with cognitive decline in Alzheimer's disease (AD), no reports have simultaneously considered the effects both factors on decline. OBJECTIVE: The purpose present study was to compare WMH rCBF relation function by developing a new software program fuse magnetic resonance imaging (MRI) single photon emission computed tomography (SPECT) data. METHOD: We...
We aimed to determine whether neuropsychological deficits and brain atrophy could predict the efficacy of non-pharmacological interventions. Forty-six participants with mild-to-moderate dementia were monitored for 6 months; 25 underwent an intervention involving physical exercise music, 21 performed cognitive stimulation tasks. Participants categorized into improvement no-improvement subgroups. In exercise-with-music group, subgroup worse than on Rivermead Behavioural Memory Test at...
Abstract Objectives Cerebral microbleeds ( CMB s) are often observed in memory clinic patients. It has been generally accepted that deep s (D‐ result from hypertensive vasculopathy HV ), whereas strictly lobar SL ‐ cerebral amyloid angiopathy CAA ) which frequently coexists with Alzheimer's disease AD ). Mixed (M‐ have partially attributed to and also . The aim of this study was elucidate the differences between M‐ terms clinical features regional distribution. Materials We examined 176...
<b><i>Background:</i></b> Since the advent of magnetic resonance imaging technology, cerebral microbleeds can be diagnosed in vivo. However, underlying mechanism microbleed formation is not fully understood. <b><i>Objectives:</i></b> This study aimed to identify factors associated with after carotid artery stenting (CAS). <b><i>Method:</i></b> We retrospectively examined 125 patients who underwent CAS for stenosis....
Purpose: Deep brain stimulation (DBS) is an established therapy for Parkinson's disease (PD). However, deteriorating cognitive function after DBS a considerable problem affected patients. This study was undertaken to predict worsening based on pulvinar findings in susceptibility-weighted imaging (SWI). Methods: We examined 21 patients with PD who underwent along SWI and neuromelanin-sensitive MR (NMI). further assessed hypointensity findings, as well the area of substantia nigra (SN) pars...