A5049548909- Cardiovascular and exercise physiology
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cardiac Structural Anomalies and Repair
- Glioma Diagnosis and Treatment
- Congenital Heart Disease Studies
- Sports Performance and Training
- RNA Interference and Gene Delivery
- Nuclear Materials and Properties
- Advanced biosensing and bioanalysis techniques
- Nuclear physics research studies
- Nuclear reactor physics and engineering
- Muscle metabolism and nutrition
- Fusion materials and technologies
- Monoclonal and Polyclonal Antibodies Research
- 3D Printing in Biomedical Research
- Cardiac Imaging and Diagnostics
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Cell Image Analysis Techniques
- RNA and protein synthesis mechanisms
- Aortic Disease and Treatment Approaches
- Microstructure and mechanical properties
Mie University
2015-2025
Fukuoka Children's Hospital and Medical Center for Infectious Diseases
2014-2025
National Institute of Advanced Industrial Science and Technology
2015-2024
Kyushu University Hospital
2020-2024
Osaka University
1990-2024
Kyushu University
2007-2024
Laboratoire de Recherche en Sciences Végétales
2024
Toho University Ohashi Medical Center
2015-2024
Toho University
2014-2024
Jikei University School of Medicine
2020-2024
Low-intensity resistance exercise training combined with blood flow restriction (REFR) increases muscle size and strength as much conventional high loads. However, the cellular mechanism(s) underlying hypertrophy gains induced by REFR are unknown. We have recently shown that both mammalian target of rapamycin (mTOR) signaling pathway protein synthesis (MPS) were stimulated after an acute bout high-intensity in humans. Therefore, we hypothesized would enhance mTOR stimulate MPS. measured MPS...
The loss of skeletal muscle mass during aging, sarcopenia, increases the risk for falls and dependence. Resistance exercise (RE) is an effective rehabilitation technique that can improve strength; however, older individuals are resistant to stimulation protein synthesis (MPS) with traditional high-intensity RE. Recently, a novel method, low-intensity RE, combined blood flow restriction (BFR), has been shown stimulate mammalian target rapamycin complex 1 (mTORC1) signaling MPS in young men....
Artificial micro‐/nanoswimmers have various potential applications including minimally invasive diagnosis and targeted therapies, environmental sensing monitoring, cell manipulation analysis, lab‐on‐a‐chip devices. Inspired by natural motile bacteria such as E. Coli , artificial bacterial flagella (ABFs) are one kind of magnetic helical microswimmers. ABFs can perform 3D navigation in a controllable fashion with micrometer precision under low‐strength rotating fields (<10 mT) promising...
Glycosuria produced by sodium–glucose co-transporter-2 (SGLT-2) inhibitors is associated with weight loss. SGLT-2 reportedly might reduce the occurrence of cardiovascular events. Epicardial adipose tissue (EAT) a pathogenic fat depot that may be coronary atherosclerosis. The present study evaluated relationship between an inhibitor (dapagliflozin) and EAT volume. In 40 diabetes mellitus patients artery disease (10 women 30 men; mean age all was 67.2 ± 5.4 years), volume compared...
The double differential cross sections at ${\ensuremath{\theta}}_{\mathrm{lab}}$ between $0.0\ifmmode^\circ\else\textdegree\fi{}$ and $12.3\ifmmode^\circ\else\textdegree\fi{}$ the polarization transfer ${D}_{\mathrm{NN}}$ $0\ifmmode^\circ\else\textdegree\fi{}$ for ${}^{90}\mathrm{Zr}(p,n)$ reaction are measured a bombarding energy of 295 MeV. A multipole decomposition technique is applied to extract $L=0$, $L=1$, $L=2$, $L=3$ contributions. Gamow-Teller (GT) strength $B(\mathrm{GT})$ in...
Single-joint resistance training with blood flow restriction (BFR) results in significant increases arm or leg muscle size and single-joint strength. However, the effect of multijoint BFR on both restricted limb non-restricted trunk muscles remain poorly understood. To examine impact bench press hypertrophic response to (chest) (upper-arm) multi-joint strength, 10 young men were randomly divided into either (BFR-T) non-BFR (CON-T) groups. They performed 30% one repetition maximal (1-RM)...
Introduction: Blood flow restriction in combination with low-intensity resistance exercise (REFR) increases skeletal muscle size to a similar extent as compared traditional high-intensity training. However, there are limited data describing the molecular adaptations that occur after REFR. Purpose: To determine whether hypoxia inducible factor-1 alpha (HIF-1α) and REDD1 mRNA expressed differently REFR no blood (CONTROL). Secondly, is able induce changes expression of several anabolic...
Abstract Transmission electron microscopic studies have been performed on lattice defects in 6H silicon carbide single crystals; the crystals were subjected to microhardness indentation tests between room temperature and 1200°C then uniaxial compression at temperatures from 1100 1650°C. It was observed that their basal dislocations, main introduced by deformation, dissociated into Shockley partials separated very wide stacking faults, energy of which evaluated be 2.5 ± 0·9 mJ m−2. The...
Cancer stem cells (CSCs) play an important role in disease recurrence after radiation treatment as a result of intrinsic properties such high DNA repair capability and antioxidative capacity. It is unclear, however, how CSCs further adapt to escape the toxicity repeated irradiation regimens used clinical practice. Here, we have exposed population murine glioma (GSCs) fractionated order investigate associated adaptive changes, with ultimate goal identifying targetable factor that regulates...
Ferroptosis, an iron-dependent form of regulated cell death, is a major death mode in myocardial ischemia reperfusion (I/R) injury, along with mitochondrial permeability transition-driven necrosis, which inhibited by cyclosporine A (CsA). However, therapeutics targeting ferroptosis during I/R injury have not yet been developed. Hence, we aimed to investigate the therapeutic efficacy deferasirox, iron chelator, against hypoxia/reoxygenation-induced cultured cardiomyocytes and injury.
An intramolecular oxidative C(sp3)–H amination from unprotected anilines and bonds readily occurs under mild conditions using t-BuOK, molecular oxygen N,N-dimethylformamide (DMF). Success of this process, which requires mildly acidic N–H an activated bond (BDE < 85 kcal/mol), stems synergy between basic, radical, oxidizing species working together to promote a coordinated sequence deprotonation: H atom transfer oxidation that forges new C–N bond. This process is applicable for the synthesis...
Abstract SiC single crystals of 6H polytype were plastically deformed by uniaxial compression at a constant strain rate temperatures between 1100 and 1800°C, their critical resolved shear stress τc strain-rate sensitivity measured as function temperature. The flow [ydot] was found to be expressible in the form (τc − τi) n exp (−U/kT), where activation energy U, exponent τi evaluated 3·4 ± 0·7 eV, 3·1 0·4 3 MPa, respectively. present study indicates that plastic under deformation conditions...
Epicardial adipose tissue (EAT) may be associated with arrhythmogenesis. P-wave indices such as dispersion and variation indicated a slowed conduction velocity within the atria. This study investigated effect of dapagliflozin on EAT volume indices.
This study was aimed at evaluating the efficacy and safety of oral immunotherapy (OIT) in children with severe cow's milk allergy. The subjects comprised 28 (aged 3–12 years) allergic symptoms that were induced by ≤ 10 mL an food challenge test (OFC). randomly allocated to treatment group (n = 14) control 14); former received rush for 2 weeks, followed a gradual increase volume 100 1 year, latter completely eliminated year. Both groups underwent OFC after had significantly higher rates...
The skin is an immune organ that contains innate and acquired systems thus able to respond exogenous stimuli producing large amount of proinflammatory cytokines including IL-1 family members. role the epidermal not limited initiation local inflammatory responses, but also induction systemic inflammation. However, association persistent release members from severe diseases such as psoriasis, epidermolysis bullosa, atopic dermatitis, blistering desmoglein-1 deficiency syndrome with in organs...
The metabolic preference of malignant glioma for glycolysis as an energy source is a potential therapeutic target. As result the cellular heterogeneity these tumors, however, relation between glycolytic preference, tumor formation, and cell clonogenicity has remained unknown. To address this issue, we analyzed profiles isogenic glioma-initiating cells (GICs) in mouse model.GICs were established by overexpression H-Ras(V12) Ink4a/Arf-null neural stem cells. Subpopulations obtained single-cell...
Abstract OBJECTIVES To examine the outcomes of patients with classical hypoplastic left heart syndrome following extracardiac total cavopulmonary connection. METHODS We retrospectively analyzed 812 cases that underwent connection at our hospital between 1994 and 2022. With a median follow-up 10.1 years, we compared survival rate, Fontan-related events, liver function, postoperative haemodynamics, freedom from reintervention, exercise tolerance in 109 (cH group), 205 heterotaxy (Hx 498 other...
Tissue-conserving partial mastectomy surgeries are often used to treat breast cancer, in which malignancies and surrounding margin tissues removed. Morphologies of assessed intraoperatively by a histopathologist, requiring excision time-consuming preparation for microscopic examination. Changes morphology appear only after the mutation cells involved tumor propagation, suggesting that margins perhaps conserved tissue may already contain cancer-converted prior morphological changes. In...