A5061881230- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Nerve injury and regeneration
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Neural and Behavioral Psychology Studies
- Neurological disorders and treatments
- Schizophrenia research and treatment
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Treatment of Major Depression
- Mental Health Research Topics
- Cannabis and Cannabinoid Research
- Attention Deficit Hyperactivity Disorder
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Pain Mechanisms and Treatments
- Regulation of Appetite and Obesity
James Cook University
2025
Yale University
2015-2024
Fraser Health
2024
National Institute of Advanced Industrial Science and Technology
2023
Osaka University
2023
University of the Sunshine Coast
2022
Aberdeen Royal Infirmary
2022
Connecticut Mental Health Center
2004-2020
Worcestershire Royal Hospital
2017
University of the Western Cape
2017
Although previous research has emphasized the beneficial effects of dopamine (DA) on functions prefrontal cortex (PFC), recent studies animals exposed to mild stress indicate that excessive DA receptor stimulation may be detrimental spatial working memory PFC (Arnsten and Goldman-Rakic, 1990; Murphy et al., 1994, 1996a,b, 1997). In particular, these have suggested supranormal D 1 receptors contribute actions in (Murphy 1996a). The current study directly tested this hypothesis by examining...
The effects of the psychotomimetic drug phencyclidine on neurochemistry and function prefrontal cortex in vervet monkeys were investigated. Monkeys treated with twice a day for 14 days displayed performance deficits task that was sensitive to function; ameliorated by atypical antipsychotic clozapine. Repeated exposure caused reduction both basal evoked dopamine utilization dorsolateral cortex, brain region has long been associated cognitive function. Behavioral decreased remained after...
The COVID-19 pandemic has made the world seem less predictable. Such crises can lead people to feel that others are a threat. Here, we show initial phase of in 2020 increased individuals' paranoia and their belief updating more erratic. A proactive lockdown people's capricious. However, state-mandated mask-wearing induced erratic behaviour. This was most evident states where adherence rules poor but rule following is typically common. Computational analyses participant behaviour suggested...
The mesolimbic dopamine (DA) system has been implicated in drug reward, locomotor sensitization, and responding for reward-related stimuli [termed conditioned reinforcers (CR)]. Here, we investigated the effect of brain-derived neurotrophic factor (BDNF), which enhances survival function dopaminergic neurons, on stimulant-induced sensitization CR. In experiment 1, BDNF was infused into nucleus accumbens (NAc) or ventral tegmental area over 2 weeks via chronically implanted minipumps (1–2.5...
Background: Stress exacerbates many neuropsychiatric disorders associated with prefrontal cortical (PFC) dysfunction. also impairs the working memory functions of PFC. Although stress research has focused on dopaminergic mechanisms, increases norepinephrine (NE) release in PFC, and intra-PFC infusions NE α-1-adrenoceptor agonists impair memory. The current study examined whether actions PFC contribute to stress-induced deficits performance.Methods: Rats were treated a pharmacological...
High concentrations of cocaethylene (EC), the ethyl ester benzoylecgonine, were measured in blood individuals who had concurrently used cocaine and ethanol. Since powerful reinforcing effects appear to be dependent on inhibition dopamine reuptake brain, we compared EC uptake system its behavioral with those cocaine. was equipotent respect binding [3H]GBR 12395 complex, [3H]dopamine into synaptosomes ability increase extracellular concentration nucleus accumbens following systemic...