A5085665261- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Genetic Mapping and Diversity in Plants and Animals
- Flexible and Reconfigurable Manufacturing Systems
- Substance Abuse Treatment and Outcomes
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Digital Transformation in Industry
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Corporate Governance and Management
- Collaboration in agile enterprises
- Learning Styles and Cognitive Differences
- Neurobiology and Insect Physiology Research
- Genetics and Physical Performance
- Innovation and Knowledge Management
- Treatment of Major Depression
- Software Engineering Techniques and Practices
- Behavioral Health and Interventions
- Mental Health Research Topics
- Scheduling and Optimization Algorithms
- Genetic Associations and Epidemiology
Binghamton University
2017-2023
Jackson Laboratory
2020-2022
Chemnitz University of Technology
2010-2015
Yale University
1997-2002
Operational Technologies Corporation (United States)
1998
Abstract Aims Alcohol use disorder is highly heterogeneous. One approach to understanding this heterogeneity the identification of drinker subtypes. A candidate classification consists reward and relief The current study examines a novel self-report measure reward, relief, habit drinking for its clinical correlates subjective response (SR) alcohol administration. Methods Non-treatment-seeking heavy drinkers (n = 140) completed brief scale (RRHDS). subset sample 67) an intravenous Individuals...
In March 2019, a scientific meeting was held at the University of California, Los Angeles (UCLA) Luskin Center to discuss approaches expedite translation neurobiological insights advances in treatment alcohol use disorder (AUD). A guiding theme that emerged while translational research AUD is clearly challenge, it also field ripe with opportunities. Herein, we seek summarize and disseminate recommendations for future using four sections. First, briefly review current landscape including...
Long-term abuse of marijuana by humans can induce profound behavioral deficits characterized cognitive and memory impairments. In particular, on tasks dependent frontal lobe function have been reported in cannabis abusers. the current study, we examined whether long-term exposure to Δ9-tetrahydrocannabinol, active ingredient marijuana, altered neurochemistry cortex rats. Two weeks administration Δ9-tetrahydrocannabinol reduced dopamine transmission medial prefrontal cortex, while metabolism...
Subchronic administration of phencyclidine to rats or monkeys produces prefrontal cortical cognitive dysfunction, as well reduced frontal dopamine utilization. In the current study, effects subchronic exposure on and acetylcholine release in cortex were assessed, using vivo microdialysis conscious rats. (5 mg/kg twice daily for 7 days) both basal extracellular concentrations increase produced by an acute challenge. The induced a high potassium concentration perfusate tended be after...
Abstract Background Interindividual variation in voluntary ethanol consumption and response is partially influenced by genetic variation. Discovery of the genes allelic variants that affect these phenotypes may clarify etiology pathophysiology problematic alcohol use, including use disorder. Genetically diverse mouse populations, which demonstrate heritable consumption, can be utilized to discover gene networks influence this trait. The Collaborative Cross (CC) recombinant inbred strains,...
It has a need to meet the demands of individual customers and solve problems in current production caused by changing markets global influence general competition situation. Utilization progress achieved information communication technologies are expected future for many manufacturing companies. This leads increasing consistent integration Information Communication Technology (ICT) into systems smaller subsystems components. Cyber-Physical System will be more involved systems. Mechatronic...
Abstract Drugs of abuse, including alcohol and stimulants like cocaine, produce effects that are subject to individual variability, genetic variation accounts for at least a portion those differences. Notably, research in both animal models human subjects point toward reward sensitivity impulsivity as being trait characteristics predict relatively greater positive subjective responses stimulant drugs. Here we describe use the eight collaborative cross (CC) founder strains 38 (reversal...
The paper introduces the conceptual framework advanced Learning Factory (aLF) highlighting its major functions for identifying learning modules, module configuration, interaction modes and transfer mechanisms in a generic factory. application of aLF is demonstrated by means two concrete examples training energy efficiency global production management.
The noncompetitive NMDA receptor antagonist phencyclidine (PCP) and the neuronal cannabinoid agonist Δ9-tetrahydrocannabinol (THC) are two agents shown to have psychotomimetic properties in humans. Both drugs increase dopamine release utilization prefrontal cortex, a brain region thought be dysfunctional schizophrenia. In present series of studies, effects acting at α-noradrenergic receptors on PCP- THC-induced increases cortical nucleus accumbens rat were examined. Clonidine, an α2...
Abstract Determining the mechanisms by which sex‐chromosome complement (SCC) affects learning, attention, and impulsivity has implications for observed sex differences in prevalence, severity, prognosis of psychiatric/neurodevelopmental disorders syndromes associated with aneuploidy. Here, Four Core Genotypes (FCG) mice were evaluated order to assess separable and/or interacting effects gonads (testes vs. ovaries) their secretions SCC (XX XY) acting via non‐gonadal on behavior. We tested FCG...
Phencyclidine (PCP) induces several distinct behavioral effects in humans and animals that appear to represent schizophrenia-like symptomatology. In humans, acute PCP exposure can induce both positive negative symptoms of schizophrenia. contrast, repeated lead enduring presentation Thus, administration may neurobiological defects mimic those present the brain patients with This chapter discusses some recent studies on rodent nonhuman primate dopamine (DA) systems how these underlie...
Klinefelter syndrome (KS; 47, XXY) and Turner (TS; 45, XO) are caused by two relatively common sex chromosome aneuploidies. These conditions associated with an increased odds of neuropsychiatric disorders, including attention deficit/hyperactivity disorder (ADHD), as well impairments in cognition that include learning delays, attentional dysfunction impulsivity. We studied cognitive functions the XY∗ mouse model, which allows comparison XXY to XY males (KS model), XO XX females (TS model)....
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United States last 10 years. Despite prevalence of disorder (CUD) personal societal problems it presents, there are currently no approved pharmaceutical treatments. The absence treatment options is due, part, our lack knowledge about etiology CUDs. There ample evidence that genetics plays a role increasing CUD risk but thus far, very few genes been identified human studies. Genetic studies mice...
Abstract Concerns about external validity of rodent models and translation findings across species are often based on narrow investigations populations with limited diversity. Sources individual variation – including genetics sex only infrequently encompassed in model organism studies. As most complex diseases, risk for cocaine use disorder is subject to considerable inter-individual variation. Explicit inclusion differences research may reveal conserved phenotypes molecular systems relevant...