A5066124186- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Obesity, Physical Activity, Diet
- Estrogen and related hormone effects
- Obesity and Health Practices
- Hormonal and reproductive studies
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Regulation of Appetite and Obesity
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Head and Neck Cancer Studies
- Physical Activity and Health
- COVID-19 Clinical Research Studies
- Histone Deacetylase Inhibitors Research
- Food Security and Health in Diverse Populations
- Brain Metastases and Treatment
- Metabolism, Diabetes, and Cancer
- Genetics, Aging, and Longevity in Model Organisms
University of Bristol
2016-2025
Medical Research Council
2022
MRC Epidemiology Unit
2021
University of Cagliari
2001
Oscillating levels of adrenal glucocorticoid hormones are essential for optimal gene expression, and maintaining physiological behavioural responsiveness to stress. The biological basis these oscillations is not known, but a neuronal "pulse generator" within the hypothalamus has remained popular hypothesis. We demonstrate that pulsatile hypothalamic activity required generating ultradian oscillations. show constant level corticotrophin-releasing hormone (CRH) can activate dynamic...
Serotonergic systems arising from the mid-rostrocaudal and caudal dorsal raphe nucleus (DR) have been implicated in facilitation of anxiety-related behavioral responses to anxiogenic drugs or aversive stimuli. In this study we attempted determine a threshold engage serotonergic neurons DR following exposure conditions an test. We manipulated intensity stimuli studies male Wistar rats by leaving them undisturbed (CO), briefly handling (HA), exposing open-field arena for 15-min under low-light...
Abstract The activity of the hypothalamic-pituitary-adrenal axis is characterized by an ultradian pulsatile pattern glucocorticoid secretion. Despite increasing evidence for importance pulsatility in regulating glucocorticoid-responsive gene transcription, little known about mechanism underlying synthesis and release. We tested hypothesis that ACTH release critical optimal adrenocortical function. Hypothalamic-pituitary-adrenal was suppressed oral methylprednisolone, (4 ng/h) infused 24h...
Objectives: To characterize the dynamics of pituitary-adrenal interaction during course coronary artery bypass grafting both on and off pump. Since our data pointed to a major change in adrenal responsiveness adrenocorticotropic hormone, we used reverse translation approach investigate molecular mechanisms underlying this rat model critical illness. Design: Clinical studies: Prospective observational study. Animal Controlled experimental Setting: Cardiac surgery operating rooms care units....
The hypothalamic–pituitary–adrenal axis is a vital neuroendocrine system that regulates the secretion of glucocorticoid hormones from adrenal glands. This characterized by dynamic ultradian hormonal oscillation, and in addition highly responsive to stressful stimuli. We have recently shown primary mechanism generating this rhythm systems-level interaction where adrenocorticotrophin hormone (ACTH) released pituitary stimulates glucocorticoids, which turn feedback at level rapidly inhibit ACTH...
Significance Our ability to respond stress depends on a remarkably dynamic process of hormone secretion. The rapid release glucocorticoid hormones from the adrenal glands is critical mount such an efficient response stress, particularly during inflammation. Although many key factors involved in this have been studied, way which these interact dynamically with one another regulate secretion has not investigated. Here, we develop mathematical model regulatory network controlling synthesis and,...
Public health attempts to prevent obesity in children and young people should aim minimize inequalities. Two Cochrane reviews examining interventions aiming childhood found that promoting (only) physical activity have a small beneficial effect on BMI for aged 5-18 years, as do alongside healthy eating 5-11 year olds. We examined whether the effectiveness of included these differed according eight factors associated with inequity: place, race/ethnicity, occupation, gender/sex, religion,...
The availability of active steroidogenic acute regulatory protein (StAR) and side-chain cleavage cytochrome P450 (P450scc) are rate-limiting steps for steroidogenesis. Transcription StAR P450scc genes depends on cyclic AMP-response element-binding (CREB) phosphorylation CREB co-activator, transducer regulated activity (TORC), which is by salt-inducible kinase 1 (SIK1). In the present study, we investigated relationship between TORC activation adrenocorticotrophic hormone (ACTH)-induced...