A5054764500- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Contact Dermatitis and Allergies
- Cardiac Ischemia and Reperfusion
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Congenital Heart Disease Studies
- Allergic Rhinitis and Sensitization
- Cardiovascular Function and Risk Factors
- Occupational exposure and asthma
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Electrospun Nanofibers in Biomedical Applications
- Blood transfusion and management
- Aortic aneurysm repair treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
University of Bristol
2016-2025
NIHR Bristol Cardiovascular Biomedical Research Unit
2016-2025
Bristol Royal Infirmary
2015-2024
Imperial College London
2011-2024
University Hospitals Bristol NHS Foundation Trust
2014-2024
University Hospitals Bristol and Weston NHS Foundation Trust
2022-2024
Hammersmith Hospital
2005-2024
Imperial College Healthcare NHS Trust
2014-2024
National Institute for Health Research
2017-2024
National Health Service
2014-2024
Background— Red blood cell transfusion can both benefit and harm. To inform decisions about transfusion, we aimed to quantify associations of with clinical outcomes cost in patients having cardiac surgery. Methods Results— Clinical, hematology, databases were linked the UK population register. Additional hematocrit information was obtained from intensive care unit charts. Composite infection (respiratory or wound septicemia) ischemic (myocardial infarction, stroke, renal impairment, failure)...
Whether a restrictive threshold for hemoglobin level in red-cell transfusions, as compared with liberal threshold, reduces postoperative morbidity and health care costs after cardiac surgery is uncertain.We conducted multicenter, parallel-group trial which patients older than 16 years of age who were undergoing nonemergency recruited from 17 centers the United Kingdom. Patients less 9 g per deciliter randomly assigned to transfusion (hemoglobin <7.5 deciliter) or <9 deciliter). The primary...
The use of radial-artery grafts for coronary-artery bypass grafting (CABG) may result in better postoperative outcomes than the saphenous-vein grafts. However, randomized, controlled trials comparing and have been individually underpowered to detect differences clinical outcomes. We performed a patient-level combined analysis compare CABG.
Pericytes are key regulators of vascular maturation, but their value for cardiac repair remains unknown.We investigated the therapeutic activity and mechanistic targets saphenous vein-derived pericyte progenitor cells (SVPs) in a mouse myocardial infarction (MI) model.SVPs have low immunogenic profile resistant to hypoxia/starvation (H/S). Transplantation SVPs into peri-infarct zone immunodeficient CD1/Foxn-1(nu/nu) or immunocompetent CD1 mice attenuated left ventricular dilatation improved...
Clinical trials in ischemic patients showed the safety and benefit of autologous bone marrow progenitor cell transplantation. Non-bone cells with proangiogenic capacities have been described, yet they remain clinically unexploited owing to their scarcity, difficulty access, low ex vivo expansibility. We investigated presence, antigenic profile, expansion capacity, potential from saphenous vein undergoing coronary artery bypass surgery.CD34-positive cells, negative for endothelial marker von...
Background —Atrial fibrillation (AF) increases the morbidity of CABG. The pathophysiology is uncertain, and its prevention remains suboptimal. This prospective, randomized study was designed to define role cardiopulmonary bypass (CPB) cardioplegic arrest in pathogenesis this complication. Methods Results —Two hundred patients were prospectively (1) on-pump conventional surgery [(100 patients, 79 men, mean age 63 (40 77) years)] with normothermic CPB heart or (2) off-pump 82 (38 86) on...
Abstract —Recent studies suggest that mast cell–derived neutral proteases can activate matrix-degrading metalloproteinases (MMPs). We have investigated the role of cell tryptase and chymase in activation MMPs human carotid endarterectomy specimens (atherosclerotic, n=32) postmortem arteries (control, n=17). In vitro degranulation cells atherosclerotic by compound 48/80 caused a significant increase MMP activity. Addition nonselective inhibitor antipain, specific trypsinlike protease...
To investigate further the mechanisms of action sildenafil, a highly selective and potent inhibitor type 5 cGMP phosphodiesterase (PDE5) that has proved effective in treatment erectile dysfunction, by assessing its effect on vitro formation cAMP corpus cavernosum rabbit.Male New Zealand White rabbits (2.5 kg) were killed their penises rapidly excised, cut into segments pooled. Penile then incubated with various concentrations sildenafil or papaverine. The was stimulated increasing sodium...
These studies examined the early time course of plaque development and destabilization in brachiocephalic artery apolipoprotein E-knockout mouse, effects pravastatin thereon, on established unstable plaques.Male mice were fed a high-fat, cholesterol-enriched diet from age 8 weeks. Animals euthanized at 1-week intervals between 4 9 weeks fat feeding. Acutely ruptured plaques observed arteries 3% animals up to including 7 feeding but 62% after weeks, which suggests that there is sharp increase...
Objective: Conventional coronary artery bypass grafting (CABG) is both safe and effective. Nevertheless, the use of cardiopulmonary (CPB) cardioplegic arrest are associated with several adverse effects. Over last 2 years there has been a revival interest in performing CABG on beating heart. In this prospective randomized study we evaluated efficacy safety off pump revascularization myocardial function. Methods: Eighty patients (65 males, mean age 61±9.7 years) undergoing first time were...
Autologous saphenous vein coronary artery bypass graft surgery is complicated by late failure due to neointima formation and subsequent atherosclerosis. Growth factors metalloproteinases (MMPs) act in concert promote formation. Tissue inhibitor of metalloproteinase-3 (TIMP-3), an extracellular matrix-associated MMP inhibitor, uniquely promotes apoptosis isolated vascular smooth muscle cells. Here, we overexpressed TIMP-3 at the luminal surface human veins before organ culture pig...