A5065130264- Substance Abuse Treatment and Outcomes
- Opioid Use Disorder Treatment
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Forensic Toxicology and Drug Analysis
- Pain Mechanisms and Treatments
- Healthcare professionals’ stress and burnout
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Alcohol Consumption and Health Effects
- Smoking Behavior and Cessation
- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Mental Health Treatment and Access
- Prenatal Substance Exposure Effects
- Pain Management and Opioid Use
- COVID-19 and Mental Health
- Pharmacology and Obesity Treatment
- Pharmacological Receptor Mechanisms and Effects
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pharmaceutical Practices and Patient Outcomes
- Complementary and Alternative Medicine Studies
- Receptor Mechanisms and Signaling
- Pharmacogenetics and Drug Metabolism
- Pain Management and Placebo Effect
University of California, Los Angeles
2015-2024
Neurobehavioral Systems
2014-2024
Los Angeles Medical Center
2023
University of Southern California
2021
National Institute on Drug Abuse
2011-2018
National Center for Advancing Translational Sciences
2018
VA Puget Sound Health Care System
2018
University of California, San Diego
2018
National Drug Addiction Center
2018
Institute of Forensic Science
2018
Background: Mood disturbances in methamphetamine (MA) abusers likely influence drug use, but the neurobiological bases for these problems are poorly understood.Objective: To assess regional brain function and its possible relationships with negative affect newly abstinent MA abusers.Design: Two groups were compared by measures of mood cerebral glucose metabolism ([ 18 F]fluorodeoxyglucose positron emission tomography) during performance a vigilance task.Setting: Participants recruited from...
ABSTRACT Aims Previous research has reported that both contingency management (CM) and cognitive‐behavioral therapy (CBT) are efficacious interventions for the treatment of stimulant abusers. The present study sought to directly compare effectiveness alone in combination reducing use. Design Randomized clinical trial. Participants Stimulant‐dependent individuals ( n = 171). Intervention CM, CBT or combined CM CBT, 16‐week conditions. condition participants received vouchers stimulant‐free...
ABSTRACT Aims Withdrawal symptoms have been linked to a propensity for relapse drug abuse. Inasmuch as this association applies methamphetamine (MA) abuse, an understanding of the course MA withdrawal may help direct treatment dependence. Previous studies manifested during abstinence from limited in size and scope. We asked (i) whether debilitating psychological and/or physical appear first several weeks abstinence, (ii) how craving evolves (iii) psychiatric (e.g. depression, psychosis)...
Elevated mortality has been observed among individuals with opioid use disorder (OUD) treated in addiction specialty clinics or programs. Information about OUD patients general healthcare settings is needed light of the current effort to integrate services into primary systems. This study examined rates, causes death, and associated risk factors a large system.Mortality data were linked electronic health records 2576 cared for university system from 2006 2014.There 465 deaths confirmed...
Ibudilast, a neuroimmune modulator which selectively inhibits phosphodiesterases (PDE)-3, -4, -10, and -11, macrophage migration inhibitory factor (MIF), shows promise as novel pharmacotherapy for alcohol use disorder (AUD). However, the mechanisms of action underlying ibudilast's effects on human brain remain largely unknown. Thus, current study examined efficacy ibudilast to improve negative mood, reduce heavy drinking, attenuate neural reward signals in individuals with AUD. Fifty-two...
Gamma‐hydroxybutyric acid (GHB) is gaining popularity as a drug of abuse. Reports toxicity and lethality associated with GHB use have increased. This survey study was designed to identify patterns use, its effects, withdrawal syndrome. A inquiring about the effects administered 42 users. The results showed that used increased feelings euphoria, relaxation, sexuality. Adverse occurred more frequently in daily users polydrug than occasional Loss consciousness reported by 66% overdose 28%%...
Institutions across the world are working to develop initiatives aimed at supporting well-being of healthcare workers (HCWs) facing psychological impacts novel coronavirus (COVID-19) pandemic.This Commentary identifies risks that HCWs experiencing, reviews sources fear and stress, describes implementation a three-tiered model for provision emotional support mental health services clinical nonclinical HCWs.The recognizes fluid, everevolving nature COVID-19 pandemic includes proactive,...
Background Subjective response to alcohol has been examined as a marker of alcoholism risk. The A 118 G single‐nucleotide polymorphism ( SNP ) the mu‐opioid receptor OPRM1 gene previously associated with subjective in heavy drinkers. This study seeks extend literature by examining effect OPRM 1 genotype on responses sample alcohol‐dependent individuals. secondary aim this is examine severity predictor alcohol. Methods Nontreatment seeking problem drinkers n = 295) were assessed laboratory...