A5016497110- Neurotransmitter Receptor Influence on Behavior
- Substance Abuse Treatment and Outcomes
- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Psychedelics and Drug Studies
- Schizophrenia research and treatment
- EEG and Brain-Computer Interfaces
- Attention Deficit Hyperactivity Disorder
- HIV Research and Treatment
- Treatment of Major Depression
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Heart Rate Variability and Autonomic Control
- HIV/AIDS Research and Interventions
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Opioid Use Disorder Treatment
- Gambling Behavior and Treatments
Baylor College of Medicine
2010-2021
Walter Reed National Military Medical Center
2019
Michael E. DeBakey VA Medical Center
2009-2018
Menninger Clinic
2017
Veterans Health Administration
2016
University of Kansas
2016
Rockefeller University
2016
Royal Blackburn Teaching Hospital
2013
University of California, Los Angeles
1998-2011
Neurobehavioral Systems
1992-2009
Background: Mood disturbances in methamphetamine (MA) abusers likely influence drug use, but the neurobiological bases for these problems are poorly understood.Objective: To assess regional brain function and its possible relationships with negative affect newly abstinent MA abusers.Design: Two groups were compared by measures of mood cerebral glucose metabolism ([ 18 F]fluorodeoxyglucose positron emission tomography) during performance a vigilance task.Setting: Participants recruited from...
Ketamine produces rapid antidepressant effects in treatment-resistant depression (TRD), but the magnitude of response varies considerably between individual patients. Brain-derived neurotrophic factor (BDNF) has been investigated as a biomarker treatment and implicated mechanism action ketamine. We evaluated plasma BDNF associations with symptoms 22 patients TRD enrolled randomized controlled trial ketamine compared to an anaesthetic control (midazolam). significantly increased levels...
This study documented the association between neurocognitive impairment and methamphetamine dependence in a sample of 27 methamphetamine-dependent individuals who achieved 5 to 14 days continuously monitored abstinence 18 control subjects. Methamphetamine-dependent performed significantly worse than subjects on measures sensitive attention/psychomotor speed, verbal learning memory, executive systems fluency. These findings are first demonstrate that is associated with impairments across...
Clinical and neuropathological evaluation of elderly subjects with dementia has traditionally concentrated upon the focal distribution brain disease, ignoring changes in complex connections that link areas are crucial for cognition. We examined two most common forms (dementia Alzheimer type or DAT, multi-infarct MID); used electroencephalographic (EEG) coherence to examine effects these illnesses on functional between areas. studied known be linked by different types connections: (i) dense...
Retrospective reports suggest that chronic use of methamphetamine is associated with a prolonged abstinence syndrome; however, there are no prospective studies confirming this. Nineteen non‐treatment‐seeking methamphetamine‐dependent volunteers participated in study mood during initial abstinence. Moderate levels depression were reported the first several days abstinence, minimal thereafter. The most prominent symptoms anhedonia, irritability, and poor concentration. syndrome dependence...
Previous research has focused on developing theories of addiction that may explain behavior in cocaine- and methamphetamine-dependent individuals. The primary goal this report was to compare contrast the prevalence self-reported measures impulsivity, depression, lifetime stress sensation-seeking healthy controls versus individuals with cocaine or methamphetamine use disorders. Twenty-nine disorders 31 were matched control participants several demographic variables. All administered...
The objective of this study was to examine the association between psychiatric symptoms and methamphetamine dependence. A four-hour survey administered 1,580 arrestees sampled from 14 most populous counties in California. included items assessing demographic profile, history substance dependence, symptomatology. In 12 months prior assessment, methamphetamine-dependent individuals were more likely report depressive suicidal ideation than denying even after controlling for profile dependence...
The primary objective of this study was to compare and contrast psychotic symptoms reported by cocaine‐ methamphetamine‐dependent individuals. Participants included 27 cocaine‐dependent 25 males, as well 15 18 females. After screening, participants were excluded if they met criteria for any Axis I diagnosis other than nicotine dependence, or methamphetamine cocaine dependence (ie, had use either but both). administered the newly developed Psychotic Symptom Assessment Scale (PSAS), which...
A variety of preclinical models have been constructed to emphasize unique aspects addiction‐like behavior. These include Negative Reinforcement (“Pain Avoidance”), Positive (“Pleasure Seeking”), Incentive Salience (“Craving”), Stimulus Response Learning (“Habits”), and Inhibitory Control Dysfunction (“Impulsivity”). We used a survey better understand why methamphetamine‐dependent research volunteers (N = 73) continue use methamphetamine, or relapse methamphetamine after period cessation use....
Cocaine dependence is associated with an increased risk of infectious diseases. The innate immune system triggers effector pathways to combat microbial pathogens through expression tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). It not known whether cocaine alters the capacity monocytes respond a bacterial challenge in humans. In cocaine-dependent volunteers control subjects, we analyzed monocyte TNF-alpha IL-6 at rest response ligand, lipopolysaccharide (LPS), over 24-h...
Modafinil improves working memory in healthy subjects and individuals diagnosed with schizophrenia Attention Deficit/Hyperactivity Disorder, though the effects of modafinil have not been evaluated on methamphetamine-dependent subjects. This double-blind, placebo-controlled study whether a daily dose 400 mg modafinil, administered over three consecutive days, would enhance performance measure relative to test at baseline following 3 days placebo administration 11 methamphetamine addicted,...