A5087899369- Neurotransmitter Receptor Influence on Behavior
- Substance Abuse Treatment and Outcomes
- Posttraumatic Stress Disorder Research
- Alcohol Consumption and Health Effects
- Treatment of Major Depression
- Traumatic Brain Injury Research
- Attention Deficit Hyperactivity Disorder
- Forensic Toxicology and Drug Analysis
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Alcoholism and Thiamine Deficiency
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Child Abuse and Trauma
- Opioid Use Disorder Treatment
- Homelessness and Social Issues
- Neural and Behavioral Psychology Studies
- Suicide and Self-Harm Studies
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Schizophrenia research and treatment
- Behavioral and Psychological Studies
- Behavioral Health and Interventions
- Sleep and related disorders
The University of Texas Health Science Center at San Antonio
2016-2025
South Texas Veterans Health Care System
2021-2024
Methodist Hospital
2020
Hudson Institute
2018
University of Virginia
2005-2011
University of Maryland, Baltimore County
2011
The University of Texas Health Science Center at Houston
1990-2008
South Texas Accelerated Research Therapeutics
2001-2008
University of Alabama
2005
National Institute on Alcohol Abuse and Alcoholism
2005
ContextEarly-onset alcoholism differs from late-onset by its association with greater serotonergic abnormality and antisocial behaviors. Thus, individuals early-onset may be responsive to treatment a selective agent.ObjectiveTo test the hypothesis that drinking outcomes associated early vs are differentially improved 5-HT3 (serotonin) antagonist ondansetron.DesignDouble-blind, randomized, placebo-controlled clinical trial.SettingsUniversity of Texas Health Science Center in Houston (April...
Effective and efficient treatment is needed for posttraumatic stress disorder (PTSD) in active duty military personnel.To examine the effects of massed prolonged exposure therapy (massed therapy), spaced (spaced present-centered (PCT), a minimal-contact control (MCC) on PTSD severity.Randomized clinical trial conducted at Fort Hood, Texas, from January 2011 through July 2016 enrolling 370 personnel with who had returned Iraq, Afghanistan, or both. Final follow-up was 11, 2016.Prolonged...
<h3>Importance</h3> Cognitive processing therapy (CPT), an evidence-based treatment for posttraumatic stress disorder (PTSD), has not been tested as individual among active-duty military. Group CPT may be efficient way to deliver treatment. <h3>Objective</h3> To determine the effects of on PTSD and co-occurring symptoms whether they differ when administered in or a group format. <h3>Design, Setting, Participants</h3> In this randomized clinical trial, 268 servicemembers consented assessment...
To determine whether group therapy improves symptoms of posttraumatic stress disorder (PTSD), this randomized clinical trial compared efficacy cognitive processing (cognitive only version; CPT-C) with present-centered (PCT) for active duty military personnel.Patients attended 90-min groups twice weekly 6 weeks at Fort Hood, Texas. Independent assessments were administered baseline, before sessions, and 2 weeks, months, 12 months posttreatment. A total 108 service members (100 men, 8 women)...
Agonists, or "replacement medications," are useful adjuncts in treatment of opiate and nicotine dependence.They have not been systematically examined cocaine dependence. Results early open trials with methylphenidate for dependence were equivocal. Twenty-four cocaine-dependent subjects enrolled an 11-week double-blind, placebo-controlled study methylphenidate. Assignment was random. Intake included a 2-day human laboratory procedure which received initial doses placebo. Subjects attended the...
Objective: Severe drinking can cause serious morbidity and death. Because the serotonin transporter (5-HTT) is an important regulator of neuronal 5-HT function, allelic differences at that gene may modulate severity alcohol consumption predict therapeutic response to 5-HT3 receptor antagonist, ondansetron. Method: The authors randomized 283 alcoholics by genotype in 5′-regulatory region 5-HTT (LL/LS/SS), with additional genotyping for another functional single-nucleotide polymorphism (T/G),...
Background The purpose of this study was to characterize the pharmacokinetics 2 homologues phosphatidylethanol ( PE th) and their combined total in uncoagulated, whole blood samples taken from participants a human clinical laboratory after consumption low doses ethanol (EtOH). Methods As part larger study, 14 male 13 female received either 0.25 or 0.50 g/kg oral EtOH during 15‐minute period. Blood were collected before throughout 6 hours each dose on day then every 3 days next days. th...
Many military service members with PTSD do not receive evidence-based specialty behavioral health treatment because of perceived barriers and stigma. Behavioral providers in primary care can deliver brief, effective treatments expanding access reducing The purpose this randomized clinical trial was to determine if a brief cognitive-behavior therapy delivered using the Primary Care Health model would be at co-occurring symptoms.A total 67 (50 men, 17 women) were trauma-focused intervention...
Background The purpose of this study was to examine the synthesis and elimination phosphatidylethanol ( PE th) 16:0/18:1 16:0/18:2 following consumption alcohol among 56 light heavy drinkers. Methods A transdermal monitor used promote absence 7 days prior, 14 after, in laboratory. Participants consumed a 0.4 or 0.8 g/kg dose 15 minutes. Blood breath samples were collected before, at various times up 360 minutes postconsumption, 2, 4, 7, 11, after consumption. Initial rates th synthesis, area...
Monitors of transdermal alcohol concentration (TAC) provide an objective measurement consumption that is less invasive than measurements in blood, breath or urine; however, there a substantial time delay the onset TAC compared to blood concentrations (BrACs). The current study examined characteristics between peak and BrAC.Data was aggregated from three experimental laboratory studies (N = 61; 32 men, 29 women) which participants wore monitor BrAC monitored while drinking one, two, three,...
Abstract Background Trauma-focused psychotherapies for combat-related posttraumatic stress disorder (PTSD) in military veterans are efficacious, but there many barriers to receiving treatment. The objective of this study was determine if cognitive processing therapy (CPT) PTSD among active duty personnel and would result increased acceptability, fewer dropouts, better outcomes when delivered In-Home or by Telehealth as compared In-Office Methods trial used an equipoise-stratified...
Importance Improved, efficient, and acceptable treatments are needed for combat-related posttraumatic stress disorder (PTSD). Objective To determine the efficacy of 2 compressed prolonged exposure (PE) therapy outpatient PTSD. Design, Setting, Participants This randomized clinical trial was conducted among military personnel veterans at 4 sites in Texas from 2017 to 2019. Assessors were blinded conditions. Data analyzed November 2020 October 2022. Interventions The interventions massed-PE,...
Subtyping alcoholics may provide a more accurate guide as to the course and character of disease. Classifications different ages onset problem drinking have so far resulted in categorical inconsistencies. In past, hospital‐based over‐represented those most severely ill, comprehensive evaluations psychopathology for discriminating between alcoholic subtypes been infrequent. heterogeneous treatment‐seeking, outpatient, population, we tested hypothesis that age represents continuum disease,...
In a residential hospital research ward setting, the effects of and preference for placebo, oxazepam (480 mg) diazepam (40, 80 160 were studied in human volunteers with histories sedative drug abuse. Doses p.o. administered every 3rd day under double-blind conditions. After an initial exposure to letter-coded test drugs, series choice days was scheduled on which subjects chose between two available alternatives. Compared oxazepam, produced greater liking (area time-action curve), peak...
On a residential research ward, the acute effects of placebo, 0.5 to 3.0 mg triazolam (TZ) and 100 600 pentobarbital (PTB) were examined using within-subject, double-blind design in male volunteers with documented histories drug abuse. Drug through use subject ratings including measures liking estimates street value, staff ratings, objective psychomotor/cognitive performance measures, performance, immediate delayed recognition memory tasks nighttime sleep quality. Staff showed that TZ PTB...
On a residential research ward, the acute effects of placebo, lorazepam (LZ) (1.5-9.0 mg) and meprobamate (MEP) (600-3600 were examined using within-subject double-blind Latin Square design in nine male subjects with histories drug abuse. Drug assessed objective performance tasks, subject estimates performance, staff ratings effects, sleep, mood, liking monetary street value. Generally, both LZ MEP produced comparable dose-related effects; had more rapid onset action on several measures...