A5010368679- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Treatment of Major Depression
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
- Mental Health and Psychiatry
- Tryptophan and brain disorders
- Electroconvulsive Therapy Studies
- Transcranial Magnetic Stimulation Studies
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Homelessness and Social Issues
- Family and Disability Support Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurotransmitter Receptor Influence on Behavior
- Body Image and Dysmorphia Studies
- Stress Responses and Cortisol
- Health disparities and outcomes
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Mental Health Treatment and Access
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Music Perception
University of Alabama at Birmingham
2021-2025
University of Alabama
2023-2024
Neurobehavioral Systems
2013-2023
University of California, Los Angeles
2013-2022
Yale University
2022
University of Washington
2022
Mental Illness Research, Education and Clinical Centers
2012-2021
VA Greater Los Angeles Healthcare System
2007-2021
Center for the Study of Healthcare Provider Behavior
2015-2021
American Psychological Association
2021
Curcumin is a polyphenolic compound derived from the plant Curcuma Long Lin that has been demonstrated to have antioxidant and anti-inflammatory effects as well on reducing beta-amyloid aggregation. It reduces pathology in transgenic models of Alzheimer's disease (AD) promising candidate for treating human AD. The purpose current study generate tolerability preliminary clinical biomarker efficacy data curcumin persons with AD.We performed 24-week randomized, double blind, placebo-controlled...
Social cognitive impairments are consistently reported in schizophrenia and associated with functional outcome. We currently know very little about whether these stable over the course of illness. In current study, 3 different aspects social cognition were assessed (emotion processing, Theory Mind [ToM], relationship perception) at distinct developmental phases illness: prodromal, first episode, chronic. this cross-sectional participants included 50 individuals prodromal risk syndrome for...
Context: Schizophrenia remains a highly disabling disorder, but the specific determinants and pathways that lead to functional impairment are not well understood.It is known whether these key of outcome lie on 1 or multiple pathways.Objective: To evaluate theoretically based models starting with early visual perception.The intervening variables were previously established drawn from 2 general categories: ability (ie, social cognition capacity) beliefs/motivation defeatist beliefs, expressive...
This study compared effects of two parent-mediated interventions on joint engagement outcomes as augmentations an early intervention program for toddlers with autism spectrum disorder (ASD).Participants included 86 (range 22-36 months) ASD and their primary caregiver. Caregiver-child dyads were randomized to receive 10 weeks hands-on parent training in a naturalistic, developmental behavioral (joint attention, symbolic play, regulation-JASPER) or parent-only psychoeducational (PEI). Dose was...
This study evaluated the longitudinal stability and functional correlates of social cognition during early course schizophrenia. Fifty-five first-episode schizophrenia patients completed baseline 12-month follow-up assessments 3 key domains (emotional processing, theory mind, social/relationship perception), as well clinical ratings real-world functioning symptoms. Scores on all cognitive tests demonstrated good with test-retest correlations exceeding .70. Higher scores were both robustly...
Long-acting, injectable, second-generation antipsychotic medication has tremendous potential to bring clinical stability persons with schizophrenia. However, long-acting medications are rarely used following a first episode of schizophrenia.To compare the efficacy injectable formulation risperidone oral in early course schizophrenia.A randomized trial performed at university-based research clinic, between 2005 and 2012. Eighty-six patients recent onset schizophrenia were receive or...
IMPORTANCEIn addition to dopaminergic hyperactivity, hypofunction of the N-methyl-D-aspartate receptor (NMDAR) has an important role in pathophysiology schizophrenia.Enhancing NMDAR-mediated neurotransmission is considered a novel treatment approach.To date, several trials on adjuvant NMDA-enhancing agents have revealed beneficial, but limited, efficacy for positive and negative symptoms cognition.Another method enhance NMDA function raise levels D-amino acids by blocking their...
<h3>Importance</h3> Neurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers clinical intervention studies. Research schizophrenia has established correlations among EAP, cognition, symptoms, functional outcome. Clarifying these associations by determining the pathways through which deficits EAP affect functioning would suggest when where to therapeutically intervene. <h3>Objectives</h3> To characterize from outcome...
Objective: The authors evaluated the effects of prenatal antidepressant exposure and maternal depression on infant gestational age at birth risk preterm birth. Method: Ninety women were followed in a prospective, naturalistic design through pregnancy with monthly assessments symptoms anxiety using Structured Clinical Interview for DSM-IV mood module depression, Hamilton Depression Rating Scale, Beck Inventory, Perceived Stress Scale. Participants included 49 major depressive disorder who...
ABSTRACT Aims Withdrawal symptoms have been linked to a propensity for relapse drug abuse. Inasmuch as this association applies methamphetamine (MA) abuse, an understanding of the course MA withdrawal may help direct treatment dependence. Previous studies manifested during abstinence from limited in size and scope. We asked (i) whether debilitating psychological and/or physical appear first several weeks abstinence, (ii) how craving evolves (iii) psychiatric (e.g. depression, psychosis)...
Various neuropsychiatric disorders, especially addictions, feature impairments in risky decision making; clarifying the neural mechanisms underlying this problem can inform treatment.To determine how methamphetamine-dependent and control participants differ brain activation during a decision-making task, resting-state functional connectivity within mesolimbic executive circuits, relationships between these measures.A case-control, magnetic resonance imaging study of healthy comparison at...
Altshuler LL, Abulseoud OA, Foland‐Ross L, Bartzokis G, Chang S, Mintz J, Hellemann Vinters HV. Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder. Bipolar Disord 2010: 12: 541–549. © 2010 The Authors. Journal compilation John Wiley & Sons A/S. Objectives: Several magnetic resonance imaging studies have found changes amygdala volumes adults mood disorders. cellular basis for these has been explored detail. Specifically, it is known whether...