A5017300902- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Plant Taxonomy and Phylogenetics
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Sleep and related disorders
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Neural dynamics and brain function
- Dietary Effects on Health
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Diet and metabolism studies
- Psychological and Temporal Perspectives Research
- Genetics and Neurodevelopmental Disorders
- Marriage and Sexual Relationships
- Sirtuins and Resveratrol in Medicine
- Spaceflight effects on biology
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
University of Pittsburgh
2016-2025
Ohio Wesleyan University
2024
New England Biolabs (United States)
2022
Jackson Laboratory
2017-2021
University of Pittsburgh Medical Center
2011-2021
Circadian (United States)
2021
Center for Neurosciences
2019
The University of Texas Southwestern Medical Center
2007-2017
Southwestern Medical Center
2007-2017
VA Connecticut Healthcare System
2014-2017
Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated, mesolimbic dopamine pathway-specific knockdown brain-derived neurotrophic factor (BDNF), we showed that BDNF is required for the development this experience-dependent aversion. Gene profiling in nucleus accumbens indicates local obliterates most effects on gene expression within circuit, with...
Circadian rhythms and the genes that make up molecular clock have long been implicated in bipolar disorder. Genetic evidence patients suggests central transcriptional activator of rhythms, CLOCK, may be particularly important. However, exact role this gene development disorder remains unclear. Here we show mice carrying a mutation Clock display an overall behavioral profile is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower...
Although there are clear interactions between circadian rhythms and drug addiction, mechanisms for such remain unknown. Here we establish a role the Clock gene in regulating brain's reward circuit. Mice lacking functional display an increase cocaine excitability of dopamine neurons midbrain ventral tegmental area, key brain region. These phenotypes associated with increased expression phosphorylation tyrosine hydroxylase (the rate-limiting enzyme synthesis), as well changes several genes...
With aging, significant changes in circadian rhythms occur, including a shift phase toward "morning" chronotype and loss of rhythmicity circulating hormones. However, the effects aging on molecular human brain have remained elusive. Here, we used previously described time-of-death analysis to identify transcripts throughout genome that rhythm expression prefrontal cortex [Brodmann's area 11 (BA11) BA47]. Expression levels were determined by microarray 146 individuals. Rhythmicity was found ∼...
Hearing in Drosophila depends on the transduction of antennal vibration into receptor potentials by ciliated sensory neurons Johnston's organ, chordotonal organ. We previously found that a protein vanilloid subfamily (TRPV) channel subunit, Nanchung (NAN), is localized to cilia and required generate sound-evoked (Kim et al., 2003). Here, we show only other TRPV mutated behavioral mutant inactive ( iav ). The IAV forms hypotonically activated when expressed cultured cells; flies, it...
The trace biogenic amine tyramine is present in the nervous systems of animals ranging complexity from nematodes to mammals. Tyramine synthesized tyrosine by enzyme decarboxylase (TDC), a member aromatic amino acid family, but this has not been identified Drosophila or higher animals. To further clarify roles and its metabolite octopamine, we have cloned two TDC genes melanogaster, dTdc1 dTdc2. Although both gene products activity vivo, expressed nonneurally, whereas dTdc2 neurally. Flies...
During periods of reduced food availability, animals must respond with behavioral adaptations that promote survival. Despite the fact many psychiatric syndromes include disordered eating patterns as a component illness, little is known about neurobiology underlying changes induced by short-term calorie restriction. Presently, we demonstrate 10 d restriction, corresponding to 20–25% weight loss, causes marked antidepressant-like response in two rodent models depression and this dependent on...
Significance One-third of bipolar disorder (BPD) patients are lithium-responsive (LiR) for unknown reasons. Were lithium’s target to be identified, then BPD’s pathogenesis might unraveled. We identified and mapped the “lithium-response pathway,” which governs phosphorylation CRMP2 , a cytoskeleton regulator, particularly dendritic spines: hence, neural network modulator. Although “toggling” between inactive (phosphorylated) active (nonphosphorylated) is physiologic, “set-point” in LiR BPD...