A5050311601- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Craniofacial Disorders and Treatments
- Neurosurgical Procedures and Complications
- Cleft Lip and Palate Research
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Spinal Fractures and Fixation Techniques
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Brain Metastases and Treatment
- Pituitary Gland Disorders and Treatments
- Trauma and Emergency Care Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Diversity and Career in Medicine
- Radiomics and Machine Learning in Medical Imaging
- Trigeminal Neuralgia and Treatments
- Surgical Simulation and Training
- Patient-Provider Communication in Healthcare
- Facial Trauma and Fracture Management
- Global Health Workforce Issues
University of California, San Diego
2016-2025
Rady Children's Hospital-San Diego
2017-2025
UC San Diego Health System
2024-2025
Neurological Surgery
2018-2025
University of Tennessee at Knoxville
2024
University of Tennessee Medical Center
2024
Primary Source
2023
University of San Diego
2022
American Society of Plastic Surgeons
2022
VA San Diego Healthcare System
2020
Significance One-third of bipolar disorder (BPD) patients are lithium-responsive (LiR) for unknown reasons. Were lithium’s target to be identified, then BPD’s pathogenesis might unraveled. We identified and mapped the “lithium-response pathway,” which governs phosphorylation CRMP2 , a cytoskeleton regulator, particularly dendritic spines: hence, neural network modulator. Although “toggling” between inactive (phosphorylated) active (nonphosphorylated) is physiologic, “set-point” in LiR BPD...
To investigate early effects of beta-amyloid (Aβ) on neuronal function, elderly normal controls (NCs, age range 58–97) were scanned with Pittsburgh Compound-B (PIB) positron emission tomography (a measure Aβ) as well functional magnetic resonance imaging brain activation) while performing an episodic memory–encoding task natural scenes (also performed by young NCs; 18–30). Relationships between Aβ and activation assessed across task-positive (regions that activate for subsequently remembered...
OBJECTIVE The available evidence suggests that the clinical benefits of extended resection are limited for chemosensitive tumors, such as primary CNS lymphoma. Oligodendroglioma is generally believed to be more sensitive chemotherapy than astrocytoma comparable grades. In this study authors compare survival benefit gross-total (GTR) in patients with oligodendroglioma relative astrocytoma. METHODS Using Surveillance, Epidemiology, and End Results (SEER) Program (1999-2010) database,...
Background Intraoperative MRI has been shown to improve gross-total resection of high-grade glioma. However, the knowledge authors, cost-effectiveness intraoperative not established. Purpose To construct a clinical decision analysis model for assessing in treatment Materials and Methods An integrated five-state microsimulation was constructed follow patients with One-hundred-thousand treated were compared 100 000 who without from initial debulking until death (median age at resection, 55...
Abstract There is an increased risk of cerebrovascular accidents (CVA) in individuals with PHACES, yet the precise causes are not well understood. In this analysis, we aimed to examine role arteriopathy PHACES syndrome as a potential contributor CVA. We analyzed clinical and radiological data from 282 patients suspected syndrome. features, including presence infantile hemangioma features based on magnetic resonance angiography or computed tomography angiography, according Garzon criteria. To...
Background: Chordoma is a rare primary tumor originating from embryonic notochord remnants, with limited systemic therapeutic options due to poor understanding of its genomic landscape. This study aims characterize the genetic alterations in chordoma using large national patient-level repository, AACR Project GENIE, identify potential targets and improve disease modeling. Methods: A retrospective analysis samples was conducted GENIE database. Targeted sequencing data were analyzed for...
Skull base neurosurgery requires a trainee to develop an intimate familiarity with three-dimensional anatomy of the target region as well approach corridor. This begins careful study two-dimensional representations including stylized drawings, exemplar dissections, and intraoperative videos. The transition from two- understanding this is challenging, often accomplished through painstaking cadaveric practice.
The pathogenesis, surgical techniques, and outcomes of pituitary adenomas (PAs) remain variable. We compared our techniques perioperative/long-term PA to highlight the hybrid microscopic/endoscopic technique used optimize efficiency, cost savings, in surgery. Consecutive cases performed from January 2017 through February 2020 were evaluated retrospectively. A analysis by approach was combining this primarily microscopic series, with endoscopic visual assist, a separate cohort consecutive...
Abstract The nature of the neurophysiological effects opioids, especially those responsible for their analgesic properties, are unknown, hindering efforts to develop non-addictive alternatives. Fentanyl and hydromorphone were administered patients experiencing semi-chronic, clinically-relevant pain after surgical implantation electrodes localization seizure onset. Opioids suppressed beta oscillations in lateral amygdala, ventral dorsolateral prefrontal cortices, increased medial amygdala...
INTRODUCTION: Contraindications to anterior cervical disc arthroplasty (ACDA) include ossification of the posterior longitudinal ligament (OPLL) and significant bridging osteophytes. CT is gold standard for identifying these findings, although whether a combination MRI plain radiographs sufficient not established. METHODS: Ten senior spine surgeons evaluated predetermined ACDA candidates’ preoperative MRIs X-rays in blinded, random review over two separate sessions. Reviewers identified...
INTRODUCTION: Chronic spinal cord injury (SCI) is a devasting condition leaving individuals with permanent deficits. Stem cell replacement provides therapeutic treatment potential for replacement, trophic support, and axon regeneration. METHODS: Three patients underwent bilateral NSI-566 implantation were followed up to 60 months prospective data collection including ISNCSCI scores, functional pain surveys, electromyography (EMG) Brain Motor Control Assessment (BMCA). RESULTS: The procedure...
INTRODUCTION: Total Intravenous Anesthesia (TIVA) has been widely adopted in neurosurgery. TIVA is favored for its ability to maintain a stable hemodynamic profile and control intracranial pressure. In addition, shown have minimal impact on neurophysiological monitoring. Despite these advantages, EEG-guided volatile anesthesia neurosurgery presents compelling alternative. Utilizing EEG, specifically, density spectral array (DSA), anesthetic delivery can be tailored individual physiological...
INTRODUCTION: Post-stroke motor deficits pose a substantial public health challenge, impacting approximately 40 million individuals globally and leading to significant long-term disability. Rehabilitation efforts, both conventional novel, achieve less than 60% recovery of upper extremity function. To date, no study has assessed electromyographic (EMG) in patients with due stroke. METHODS: With IRB approval, (> 18 years) admitted for ischemic or hemorrhagic subcortical stroke isolated...
INTRODUCTION: The newest generation distal thrombectomy catheters are intended for use with larger wires in lieu of a microcatheter triaxial aspiration systems used the treatment LVO strokes. METHODS: stroke time cards and outcomes all patients from October 2022 to March 2023 April September at our institution were retrospectively reviewed. intervals question correspond thrombectomies performed prior after implementation Penumbra Red 43 catheter institution, respectively. Patients posterior...
A 3-year-old male presented with a history of nasal dermoid cyst intracranial extension as well concomitant isolated the middle cranial fossa. Initially, at 2 years age, he underwent successful transnasal endoscopic resection an anterior skull base cyst. He then for staged right sphenoid bone lesser wing because interval growth between imaging studies. right-sided transorbital neuroendoscopic approach (TONES) was utilized lesion resection. gross-total achieved, no complications. Excellent...