A5028328929- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Pituitary Gland Disorders and Treatments
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Radiomics and Machine Learning in Medical Imaging
- Intracranial Aneurysms: Treatment and Complications
- Bone Tumor Diagnosis and Treatments
- Fetal and Pediatric Neurological Disorders
- Oral and Maxillofacial Pathology
- Facial Nerve Paralysis Treatment and Research
- Medical Imaging and Analysis
- Sarcoma Diagnosis and Treatment
- Medical Image Segmentation Techniques
- Teratomas and Epidermoid Cysts
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Spine and Intervertebral Disc Pathology
- Surgical Simulation and Training
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
The University of Texas Health Science Center at Houston
2024
Boston Children's Hospital
2020-2023
Cornell University
2016-2017
New York Hospital Queens
2017
Neurological Surgery
2017
NewYork–Presbyterian Hospital
2017
Stanford University
2017
Weill Cornell Medicine
2017
We propose a method for the automated identification of key white matter fiber tracts neurosurgical planning, and we apply in retrospective study 18 consecutive patients with brain tumors. Our is designed to be relatively robust challenges tractography, which include peritumoral edema, displacement, mass effect caused by lesions. The proposed has two parts. First, learn data-driven parcellation or cluster atlas using groupwise registration spectral clustering multi-fiber tractography from...
Abstract Diffusion MRI (dMRI) is the only noninvasive method for mapping white matter connections in brain. We describe SlicerDMRI, a software suite that enables visualization and analysis of dMRI neuroscientific studies patient-specific anatomic assessment. SlicerDMRI has been successfully applied multiple human brain health disease, here, we especially focus on its cancer research applications. As an extension module 3D Slicer medical image computing platform, clinically relevant...
Purpose Peritumoral edema impedes the full delineation of fiber tracts due to partial volume effects in image voxels that contain a mixture cerebral parenchyma and extracellular water. The purpose this study is investigate effect incorporating free water (FW) model for white matter tractography presence edema. Materials methods We retrospectively evaluated 26 consecutive brain tumor patients with diffusion MRI T2-weighted images acquired presurgically. Tractography arcuate fasciculus (AF)...
OBJECTIVE The authors describe the supraorbital keyhole approach to contralateral medial optic nerve and tract, both in a series of cadaveric dissections 2 patients. They also discuss indications contraindications for this procedure. METHODS In 3 cadaver heads, bilateral minicraniotomies were performed expose ipsilateral nerves. extent exposure was assessed. patients, used remove pathology tract. RESULTS craniotomy provided better superomedial than it did same portion nerve. patients...
OBJECTIVE Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy was recently approved for use in the treatment of medication-refractory essential tremor (ET). Previous work has described lesion appearance and volume on MRI up to 6 months after treatment. Here, authors report volumetric segmentation associated edema immediate postoperative period 1 year following treatment, relate these radiographic characteristics with clinical outcome. METHODS Seven patients ET underwent MRgFUS...
OBJECTIVE Sporadic cases of endonasal intraaxial brainstem surgery have been reported in the recent literature. The authors endeavored to assess feasibility and limitations endoscopic for approaching lesions ventral portion brainstem. METHODS Five human cadaveric heads were used anatomy record various measurements. Extended transsphenoidal transclival approaches performed. After exposing brainstem, white matter dissection was attempted through this window, additional key measurements taken....
Cellular therapies offer a promising therapeutic strategy for the highly malignant brain tumor, glioblastoma (GBM). However, their clinical translation is limited by lack of effective target identification and stringent testing in pre-clinical models that replicate standard treatment GBM patients. In this study, we show detection cell surface death receptor (DR) on CD146-enriched circulating tumor cells (CTC) captured from blood mice bearing patients diagnosed with GBM. Next, developed...
The authors present 4 cases in which they used intraoperative CT (iCT) scanning to provide real-time image guidance during endonasal odontoid resection. While has previously been as a confirmatory test after resection, the authors’ knowledge this is first time it operating room setup, well advantages and pitfalls of approach, are discussed. A mobile scanner was conjunction with craniospinal neuronavigation patients who underwent endoscopic odontoidectomy for basilar invagination. All...
OBJECTIVE Endoscopic endonasal approaches are increasingly performed for the surgical treatment of multiple skull base pathologies. Preventing postoperative CSF leaks remains a major challenge, particularly in extended approaches. In this study, authors assessed potential use modern multimaterial 3D printing and neuronavigation to help model these defects develop specifically tailored prostheses reconstructive purposes. METHODS Extended endoscopic were on 3 human cadaveric heads....
ABSTRACT BACKGROUND AND PURPOSE Diffusion magnetic resonance imaging (dMRI) provides preoperative maps of neurosurgical patients’ white matter tracts, but these suffer from echo‐planar (EPI) distortions caused by field inhomogeneities. In clinical planning, are generally not corrected and thus contribute to the uncertainty fiber tracking. Multiple image processing pipelines have been proposed for image‐registration‐based EPI distortion correction in healthy subjects. this article, we perform...
We describe the feasibility of using minimally invasive robotic laser interstitial thermotherapy (LITT) for achieving an anterior two-thirds as well a complete corpus callosotomy.Ten probe trajectories were plotted on normal magentic resonance imaging (MRI) scans Brainlab Stereotactic Planning Software (Brainlab, Munich, Germany). The NeuroBlate® System (Monteris Medical, MN, USA) was used to conform thermal burn callosum along trajectory probe. distance ideal entry site from either coronal...
Vertebral artery injury (VAI) is a potential catastrophic complication of Goel and Harms C1-C2 posterior arthrodesis. Meticulous study preoperative spinal CT angiography together with neuronavigation plays fundamental role in avoiding VAI. Doppler ultrasonography may be an additional intraoperative tool, providing real-time identification the vertebral (VA) thus helping its preservation.Thirty-three consecutive patients unstable odontoid fractures underwent Surgery was performed aid lateral...
ABSTRACT BACKGROUND AND PURPOSE Functional magnetic resonance imaging (fMRI) is becoming widely recognized as a key component of preoperative neurosurgical planning, although intraoperative electrocortical stimulation (ECS) considered the gold standard surgical brain mapping method. However, acquiring and interpreting ECS results can sometimes be challenging. This retrospective study assesses whether availability fMRI impacted decision‐making when was problematic or unobtainable. METHODS...