A5014733785- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Spinal Fractures and Fixation Techniques
- Pituitary Gland Disorders and Treatments
- Immune cells in cancer
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Pluripotent Stem Cells Research
- Diversity and Career in Medicine
- Neurogenesis and neuroplasticity mechanisms
- Surgical Simulation and Training
- Epigenetics and DNA Methylation
- Vascular Malformations Diagnosis and Treatment
- Teratomas and Epidermoid Cysts
- Craniofacial Disorders and Treatments
- Estrogen and related hormone effects
- Neurosurgical Procedures and Complications
- Spinal Cord Injury Research
Cornell University
2016-2025
Weill Cornell Medicine
2017-2025
Neurological Surgery
2016-2025
Presbyterian Hospital
2015-2024
New York Hospital Queens
2015-2024
NewYork–Presbyterian Hospital
2015-2024
Memorial Sloan Kettering Cancer Center
2012-2024
Columbia University Irving Medical Center
2022
Creative Commons
2021
Lander Institute
2020
Recent work has highlighted the tumor microenvironment as a central player in cancer. In particular, interactions between and immune cells may help drive development of brain tumors such glioblastoma multiforme (GBM). Despite significant research into molecular classification glioblastoma, few studies have characterized comprehensive manner infiltrate situ within different GBM subtypes.In this study, we use an unbiased, automated immunohistochemistry-based approach to determine phenotype...
The excessive generation and accumulation of 40- 42-aa beta-amyloid peptides (Abeta40/Abeta42) in selectively vulnerable brain regions is a major neuropathological feature Alzheimer's disease. Abeta, derived by proteolytic cleavage from the precursor protein (betaAPP), normally secreted. However, recent evidence suggests that significant levels Abeta also may remain inside cells. Here, we have investigated subcellular compartments within which distinct amyloid species are generated they...
Alzheimer's disease (AD) is characterized by the age-related deposition of β-amyloid (Aβ) 40/42 peptide aggregates in vulnerable brain regions. Multiple levels evidence implicate a central role for Aβ pathophysiology AD. peptides are generated regulated cleavage an ≈700-aa precursor protein (βAPP). Full-length βAPP can undergo proteolytic either within domain to generate secreted sβAPPα or at N- and C-terminal domain(s) amyloidogenic peptides. Several epidemiological studies have reported...
BACKGROUND The endoscopic, endonasal, extended transsphenoidal approach is a minimal-access technique for managing craniopharyngiomas. Outcome measures such as return to employment and body mass index (BMI) have not been reported are necessary comparison with open transcranial approaches. Most prior reports of the endonasal unacceptably high cerebrospinal fluid (CSF) leak rates. OBJECTIVE To assess outcome surgery in consecutive series craniopharyngiomas special attention extent resection,...
The gold-standard surgical approach to the odontoid is via transoral route. This necessitates opening of oropharynx and associated with risks infection, swallowing breathing complications. endoscopic endonasal has potential reduce these complications as oral cavity avoided. There are fewer than 25 such cases reported date. authors present a consecutive, single-institution series 9 patients who underwent odontoid.The charts surgery between January 2005 August 2013 were reviewed. clinical...
Abstract A central mechanism of tumour progression and metastasis involves the generation an immunosuppressive ‘macroenvironment’ mediated in part through tumour-secreted factors. Here we demonstrate that upregulation Inhibitor Differentiation 1 (Id1), response to tumour-derived factors, such as TGFβ, is responsible for switch from dendritic cell (DC) differentiation myeloid-derived suppressor expansion during progression. Genetic inactivation Id1 largely corrects myeloid imbalance, whereas...
Abstract Background Safe sampling of central nervous system tumor tissue for diagnostic purposes may be difficult if not impossible, especially in pediatric patients, and an unmet need exists to develop less invasive tests. Methods We report our clinical experience with minimally molecular diagnostics using a clinically validated assay sequencing cerebrospinal fluid (CSF) cell-free DNA (cfDNA). All CSF samples were collected as part care, results reported both clinicians patients/families....
Pediatric brain tumors are the leading cause of cancer-related death in children United States and contribute a disproportionate number potential years life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary The Children's Brain Tumor Network (CBTN) is multi-institutional international clinical research consortium created advance therapeutic development through collection rapid distribution biospecimens data via open-science...
Abstract Background The prognosis for metastatic and recurrent tumors of the central nervous system (CNS) remains dismal, need newer therapeutic targets modalities is critical. cell surface glycoprotein B7H3 expressed on a range solid with restricted expression normal tissues. We hypothesized that compartmental radioimmunotherapy (cRIT) anti-B7H3 murine monoclonal antibody omburtamab injected intraventricularly could safely target CNS malignancies. Patients methods conducted phase I trial...
Presenilins (PS1/PS2) play a critical role in proteolysis of β-amyloid precursor protein (βAPP) to generate β-amyloid, peptide important the pathogenesis Alzheimer's disease. Nevertheless, several regulatory functions PS1 have also been reported. Here we demonstrate, neuroblastoma cells, that regulates biogenesis βAPP-containing vesicles from thetrans-Golgi network and endoplasmic reticulum. deficiency or expression loss-of-function variants leads robust vesicle formation, concomitant with...
OBJECTIVE The anterior skull base, in front of the sphenoid sinus, can be approached using a variety techniques including extended subfrontal, transfacial, and craniofacial approaches. These methods include risks brain retraction, contusion, cerebrospinal fluid leak, meningitis, cosmetic deformity. An alternate more direct approach is endonasal, transethmoidal, transcribriform, transfovea ethmoidalis approach. METHODS endoscopic, endonasal was used to treat conditions base arising sinus...
OBJECTIVE Deep-seated supratentorial intraparenchymal and intraventricular brain lesions can be difficult to access without causing significant trauma the overlying cortex intervening white matter tracts. Traditional retractors use multiple blades, which do not exert pressure in an equally distributed fashion. Tubular offer advantage. Although a commercially available frame-based tubular retractor system is on market (COMPASS; Compass, Inc., Rochester, MN), we modified existing off-the-shelf...
Evidence-based traumatic brain injury guidelines support cerebral perfusion pressure thresholds for adults at a class 2 level, but evidence is lacking in younger patients. The purpose of this study to identify the impact age-specific on short-term survival among patients with severe injury.
OBJECTIVE The expanded endonasal endoscopic transsphenoidal approach has become increasingly used for craniopharyngioma surgery in the pediatric population, but questions still persist regarding its utility younger children, recurrent and irradiated tumors, masses primarily located suprasellar region. narrow corridor, incomplete pneumatization, fear of hypothalamic injury have traditionally relegated this to application older children with mostly cystic craniopharyngiomas centered sella....
OBJECTIVE Craniopharyngiomas can be difficult to remove completely based on their intimate relationship with surrounding visual and endocrine structures. Reoperations are not uncommon but have been associated higher rates of complications lower extents resection. So radiation is often offered as an alternative reoperation. The endonasal endoscopic transsphenoidal approach has used in recent years for craniopharyngiomas previously removed craniotomy. impact this reoperations widely...
Endoscopic endonasal approaches (EEAs) to the skull base have evolved over last 20 years become an essential component of a comprehensive practice. Many case series show learning curve from earliest cases, in which authors were inexperienced or not using advanced closure techniques. It is generally accepted that once this achieved, plateau reached with little incremental improvement. Cases performed during early steep eliminated examine whether continued improvement exists "tail end" curve.
OBJECT Craniopharyngiomas are benign parasellar tumors for which surgical removal, although potentially curative, often leads to morbidity with resulting decreases in quality of life (QOL). The endonasal endoscopic approach is a minimal-access technique removing these and may reduce postoperative morbidity. QOL following this method resection craniopharyngiomas has not been documented. METHODS authors reviewed database consecutive surgeries done at Weill Cornell Medical College. Adult...
Gross-total resection (GTR) of craniopharyngiomas (CPs) is potentially curative and often the goal surgery, but endocrinopathy generally results if stalk sacrificed. In some cases, GTR can be attempted while still preserving stalk; however, manipulation or devascularization may cause this strategy risks leaving behind small tumor remnants that recur.
Estrogen reduces the risk of Alzheimer's disease in post-menopausal women, β-amyloid (Aβ) burden animal models disease, and secretion Aβ from neuronal cultures. The biological basis for these effects remains unknown. Here, utilizing cell-free systems derived both neuroblastoma cells primary neurons, we demonstrate that 17β-estradiol (17β-E2) stimulates formation vesicles containing precursor protein (βAPP) trans-Golgi network (TGN). Accelerated βAPP trafficking precludes maximal generation...
The authors report a case of nonachondroplastic dwarf with severe basilar invagination and compression the cervicomedullary junction (CMJ) due to juvenile rheumatoid arthritis. Initially excellent reduction decompression CMJ was achieved using posterior fixation. However, 1 month postoperatively symptoms recurred found imaging evidence recurrence as well. patient subsequently underwent an endoscopic transnasal resection dens assistance Iso-C navigation. He recovered well tolerated regular...
Object Simultaneous endoscopic third ventriculostomy (ETV) and tumor biopsy is a widely accepted therapeutic diagnostic procedure for patients with noncommunicating hydrocephalus secondary to pineal region tumor. Multiple approaches have been advocated, including the use of steerable fiberoptic or rigid lens endoscope via 1 2 trajectories. However, optimal approach has not established based on individual anatomical characteristics patient. Methods A retrospective review undergoing...