A5100365808- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Gout, Hyperuricemia, Uric Acid
- Immune Response and Inflammation
- Tuberculosis Research and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Clostridium difficile and Clostridium perfringens research
- Inflammasome and immune disorders
- Gut microbiota and health
- Vasculitis and related conditions
- Drug-Induced Adverse Reactions
- Eosinophilic Disorders and Syndromes
- Mycobacterium research and diagnosis
- Biomarkers in Disease Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sarcoidosis and Beryllium Toxicity Research
- Autoimmune Bullous Skin Diseases
- Systemic Sclerosis and Related Diseases
- Salivary Gland Disorders and Functions
- Radiomics and Machine Learning in Medical Imaging
- Potassium and Related Disorders
Inner Mongolia Medical University
2016-2025
Harvard University
2025
Brigham and Women's Hospital
2025
Inner Mongolia Medical College Hospital
2014-2025
Xinxiang Medical University
2024
University of Lausanne
2023
First Affiliated Hospital of Jiamusi University
2019
Harbin Medical University
2019
Third Affiliated Hospital of Harbin Medical University
2019
Wuxi Third People's Hospital
2015
To compare the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with methotrexate (MTX) in treatment active rheumatoid arthritis (RA).Design: a multicentre, open-label, randomised controlled trial. All patients were assessed by trained investigators who unaware therapeutic regimen.207 RA randomly allocated (1:1:1) to MTX 12.5 mg once week, or TwHF 20 three times day, two combination. At week 12, if reduction 28-joint count Disease Activity Score (DAS28) was <30% monotherapy...
Gout is characterized by dysregulation of uric acid (UA) metabolism, and the gut microbiota may serve as a regulatory target. This two-month randomized, double-blind, placebo-controlled trial aimed to investigate additional benefits coadministering Probio-X alongside febuxostat. A total 160 patients with gout were randomly assigned either probiotic group (n = 120; [3 × 10
Abstract Objective Early personalized identification of systemic sclerosis (SSc) patients at risk for scleroderma renal crisis (SRC) can help provide better treatment and improve outcomes. This study aimed to create validate a new multi-predictor nomogram predict SRC compare it an existing model. Methods A retrospective multicentre observational was conducted using clinical data from SSc with registered in the Chinese Rheumatism Data Center (CRDC) database. Each patient matched four without...
The present comparative study aimed to investigate the effects of different doses febuxostat on uric acid, inflammatory factors serum, knee articular cavity, endothelin-1, and oxidative stress in patients with gout. 80 cases hyperuricemia admitted our hospital (January 2018- March 2020) were randomly distributed into two groups. control group was administered 40 mg tablets daily., whereas treatment daily. Data collected from groups patients, including acid level, TNF-α levels serum vascular...
Background: Psoriasis is a common immune-mediated inflammatory dermatosis. Generalized pustular psoriasis (GPP) the severe and rare type of psoriasis. The association between tumor necrosis factor-alpha induced protein 3 interacting 1 (TNIP1) gene was confirmed in people with multiple ethnicities. This study to investigate TNIP1 polymorphisms Chinese Han population. Methods: Seventy-three patients GPP, 67 palmoplantar pustulosis (PPP), 476 healthy controls were collected from Six single...
Evidence of active tuberculosis (ATB) in patients with rheumatic diseases are research priorities but limited data from China have been reported. Research targeting not taking anti-TNF biologics especially insufficient. We aimed to investigate the prevalence and risk factors ATB this at-risk population. conducted a tertiary hospital-based, multi-center, cross-sectional study by using stratified multi-stage cluster sampling strategy screen diseases. estimated identified among those who were...
Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease involving multiple organ systems. The Janus kinase/signal transduction and activator of transcription (JAK/STAT) signaling pathway key the pathogenesis pSS. Baricitinib, selective JAK1 JAK2 inhibitor, has been approved for treatment active rheumatoid arthritis reported in some other diseases including lupus erythematosus. We have found that baricitinib might be effective safe pSS pilot study. However, there no published...
Background To explore the associations of changes in serum inflammatory factors, matrix metalloproteinase-3 (MMP-3), 25-hydroxy vitamin D [25(OH)D], and intestinal flora with osteoporosis disease activity rheumatoid arthritis (RA) patients, so as to provide references for clinical diagnosis treatment. Methods A total 98 RA patients were selected objects study (RA group), divided into active-stage group (n = 56) remission-stage 42) according score (DAS28). Another 50 healthy people receiving...
Background: Toll-like receptor 4 (TLR4), a member of the pattern recognition receptors, has been reported to be involved in carcinogenesis. However, clinical impact TLR4 peripheral T-cell lymphomas (PTCL) remains unclear. Methods: The current study, using immunohistochemical staining, first examined and programmed cell death-ligand 1 (PD-L1) expression patients with PTCL, correlate PD-L1 clinicopathological parameters. Results: It was found that rates high were 41.7% 45.8%, respectively....
Serum galectin-3 (Gal-3) in patients with hypertension complicated diastolic dysfunction and its predictive value for efficacy were investigated. One hundred admitted to the First Affiliated Hospital of Jiamusi University from June 2017 December 2018 enrolled as group A, symptomatically treated conventional drugs. Further 80 individuals undergoing physical examination during same period B. Patients two groups subjected echocardiography observe mitral valve early peak flow velocity (EPFV),...
The objectives of this study were to screen for latent tuberculosis infection (LTBI) among patients with systemic lupus erythematosus (SLE) using the T-SPOT.TB assay and identify factors affecting results. SLE enrolled from 13 tertiary hospitals in eastern, central, western China September 2014 March 2016 screened detect LTBI. Basic information about subjects was collected, including gender, age, body mass index (BMI), course disease, evidence previous tuberculosis, Systemic Lupus...
Abstract Aim To describe the clinical characteristics of Chinese patients with psoriatic arthritis (PsA) using data recorded in Registry Psoriatic Arthritis (CREPAR). Methods This is a cross‐sectional study based on CREPAR registry, which prospective registry founded December 2018. Data regarding and treatment were collected during every visit. at enrollment extracted, analyzed, compared other registries or cohorts. Results A total 1074 registered from 2018 to June 2021. Of these, 929...
Previous studies have indicated a potential association between the alanine aminotransferase to high-density lipoprotein cholesterol (ALT/HDL-C) ratio and risk of Type 2 Diabetes Mellitus, but its relation with gestational diabetes mellitus (GDM) remains uncertain. This study aims investigate correlation ALT/HDL-C in early pregnancy GDM. is secondary analysis based on an open-source cohort study. A total 590 single pregnant women attending two hospitals Korea up 14 weeks gestation were...