A5008578879- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects of Natural Compounds
- Photodynamic Therapy Research Studies
- Toxoplasma gondii Research Studies
- Nanoplatforms for cancer theranostics
- Herpesvirus Infections and Treatments
- Phytochemistry and biological activity of medicinal plants
- Research on Leishmaniasis Studies
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Magnolia and Illicium research
- Rabies epidemiology and control
- Environmental Toxicology and Ecotoxicology
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Groundwater and Isotope Geochemistry
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Toxin Mechanisms and Immunotoxins
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- Water Quality and Pollution Assessment
Hebei Medical University
2015-2025
National Medical Products Administration
2021-2025
Southern University of Science and Technology
2019-2025
Second Hospital of Hebei Medical University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Dalian Medical University
2024-2025
Second Affiliated Hospital of Dalian Medical University
2025
Northeast Agricultural University
2025
ShenZhen People’s Hospital
2018-2025
Guangdong Ocean University
2025
To compare the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with methotrexate (MTX) in treatment active rheumatoid arthritis (RA).Design: a multicentre, open-label, randomised controlled trial. All patients were assessed by trained investigators who unaware therapeutic regimen.207 RA randomly allocated (1:1:1) to MTX 12.5 mg once week, or TwHF 20 three times day, two combination. At week 12, if reduction 28-joint count Disease Activity Score (DAS28) was <30% monotherapy...
To assess the efficacy/safety of ivarmacitinib, a selective Janus kinase (JAK) 1 inhibitor, in patients with moderate-to-severe active rheumatoid arthritis (RA) who had an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). Patients were randomised (1:1:1) receive either placebo (n=188), ivarmacitinib 4 mg (n=189) or 8 once daily, background csDMARDs allowed. After 24 weeks, on switched for additional 28 while those continued their initial dosage....
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting both upper and lower motor neurons (MNs) with large unmet medical needs. Multiple pathological mechanisms are considered to contribute the progression of ALS, including neuronal oxidative stress mitochondrial dysfunction. Honokiol (HNK) has been reported exert therapeutic effects in several neurologic models ischemia stroke, Alzheimer's Parkinson's disease. Here we found that honokiol also exhibited...
Environmental factors play an important role in the development of rheumatoid arthritis (RA). Among these factors, smoking is generally considered to be established risk factor for RA. Data regarding impact diet on RA limited. This study assessed dietary patterns susceptibility Chinese populations. was a large scale, case-control composed 968 patients with and 1037 matched healthy controls. Subjects were recruited from 18 teaching hospitals. Socio-demographic characteristics intakes 5 years...
Abstract Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression multiple clinical cohorts comprising 402 primary, locally recurrent metastatic NPCs. We show that SSTR2 induced by Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via NF-κB pathway. Using cell-based preclinical...
Against tumor-dependent metabolic vulnerability is an attractive strategy for tumor-targeted therapy. However, inhibitors are limited by the drug resistance of cancerous cells due to their plasticity and heterogeneity. Herein, choline metabolism was discovered spatially resolved metabolomics analysis as which highly active in different cancer types, a choline-modified small molecule-drug conjugates (SMDCs) design developed fool tumor into indiscriminately taking chemotherapy drugs targeted...
Tripterygium wilfordii Hook F (TwHF) alone or in combination with methotrexate (MTX) has been shown to be more effective than MTX monotherapy controlling the manifestations subjects disease-modifying antirheumatic drug (DMARD)-naïve active rheumatoid arthritis (RA) over a 6-month period. The long-term impact of these therapies on disease activity and radiographic progression RA not examined.Patients DMARD-naïve enrolled "Comparison Treatment Active Rheumatoid Arthritis" (TRIFRA) study were...
Thickened skin is a major clinical feature in patients with systemic sclerosis (SSc). We investigated changes of thickness SSc using both high frequency ultrasound (HFU) and the modified Rodnan score (mRSS) to evaluate feasibility application HFU involvement relationship between profiles. recruited 31 consecutive age-matched sex-matched healthy controls this prospective, cross-sectional study. Skin was measured by an 18-MHz ultrasonic probe at five different sites. Total (TST) categorical...
Curcumin has a therapeutic effect on ulcerative colitis, but the underlying mechanism yet to be elucidated. The aim of present study was clarify possible mechanisms. Dextran sulfate sodium‑induced colitis mice were treated with curcumin via gavage for 7 days. effects disease activity index (DAI) and pathological changes colonic tissue in determined. Interleukin (IL)‑6, IL‑10, IL‑17 IL‑23 expression levels measured by ELISA. Flow cytometry used detect ratio mouse spleen regulatory T cells...
Abstract Atmospheric particle is one of the risk factors for respiratory disease; however, their injury mechanisms are poorly understood, and prevention methods highly desirable. We constructed artificial PM 2.5 (aPM ) particles according to size composition actual collected in Beijing. Using these particles, we created an inhalation-injury animal model. These aPM simulate physical chemical characteristics , inhalation rat results a time-dependent change lung suggesting declined function,...
Leptin levels are increased in patients with systemic lupus erythematosus (SLE) but little is known on how this correlates several disease characteristics including the frequency of regulatory T cells (Tregs). Here we compared serum leptin circulating Tregs 47 vs. 25 healthy matched controls. Correlations activity were also analyzed, as well Treg proliferation potential. It was found that remarkably SLE to controls, particularly moderate and severe active SLE, increase correlated activity....
Prostate cancer (PCa) is a major serious malignant tumor and commonly diagnosed in older men. Identification of novel cancer-related genes PCa important for understanding its tumorigenesis mechanism developing new therapies against PCa. Here, we used RNA sequencing to identify the specific genes, which are upregulated cell lines tissues. The division cycle associated protein (CDCA) family, plays critical role proliferation, our RNA-Sequencing data. Moreover, found that CDCA2 overexpressed,...
Objective The efficacy of sirolimus in treating severe or refractory systemic lupus erythematosus (SLE) has been confirmed by small-scale clinical trials. However, few studies focused on mild moderate SLE. Therefore, this study we elucidated add-on patients with Methods Data 17 consecutive SLE were retrospectively collected. Disease Activity Index-2000 (SLEDAI-2K), manifestation, laboratory data and peripheral T lymphocyte subsets cytokines collected before 6 months after treatment. cell...