A5042290638- Mesenchymal stem cell research
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Sports and Physical Education Research
- Dermatologic Treatments and Research
- Connective Tissue Growth Factor Research
- Inclusion and Disability in Education and Sport
- Regulation of Appetite and Obesity
- Cytokine Signaling Pathways and Interactions
- Children's Physical and Motor Development
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Systemic Sclerosis and Related Diseases
- Galectins and Cancer Biology
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Birth, Development, and Health
- Extracellular vesicles in disease
Hebei Medical University
2017-2025
Second Hospital of Hebei Medical University
2017-2025
Shandong Normal University
2022
Heilongjiang Bayi Agricultural University
2019
Leptin levels are increased in patients with systemic lupus erythematosus (SLE) but little is known on how this correlates several disease characteristics including the frequency of regulatory T cells (Tregs). Here we compared serum leptin circulating Tregs 47 vs. 25 healthy matched controls. Correlations activity were also analyzed, as well Treg proliferation potential. It was found that remarkably SLE to controls, particularly moderate and severe active SLE, increase correlated activity....
Objective The efficacy of sirolimus in treating severe or refractory systemic lupus erythematosus (SLE) has been confirmed by small-scale clinical trials. However, few studies focused on mild moderate SLE. Therefore, this study we elucidated add-on patients with Methods Data 17 consecutive SLE were retrospectively collected. Disease Activity Index-2000 (SLEDAI-2K), manifestation, laboratory data and peripheral T lymphocyte subsets cytokines collected before 6 months after treatment. cell...
T cells play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE), with their functions regulated by various metabolic pathways. This study explores SLE and therapeutic effects human umbilical cord-derived mesenchymal stem (hUC-MSCs) via reprogramming. Clinical data peripheral blood samples were collected from 15 patients matched healthy controls. CD4+ isolated activated vitro anti-CD3/CD28. Following 72 h co-culture hUC-MSCs, cell viability was assessed using CCK-8...
Sjogren's syndrome (SS) is a chronic autoimmune disease, particularly involving the lacrimal and salivary glands, with dryness as main symptom. To date, pathogenesis of SS not fully understood. Recently, numerous miRNAs were implicated in etiology pathogenesis.Ocular wash was collected from patients healthy controls. INF-γ-treated gland epithelial cells (SGECs) utilized vitro models. Expressions miR-223-3p inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) ocular specimens measured by...
To study the effects of prenatal cold stress on behavior and mood offspring in pregnant rats.Six SPF-class Wister rats were randomly divided into normal temperature control group with 3 each group. The female kept environment (22 ±2)℃, placed artificial intelligence climate chamber at(4 ±0.1)℃ for 7 days before birth, young after born. After born, they male (MR, 22), mother (FR, 15), (MC, (FC, 15) .In fourth generation offspring, open field experiment elevated cross maze test carried out.In...
Abstract Background: T cells play a crucial role in the development of systemic lupus erythematosus(SLE), and their function is mediated by various metabolic pathways enzyme activities. Here, we aim to analyze phenotype glucose metabolism peripheral blood CD4 + cells. Also, effects human umbilical cord-derived mesenchymal stem (hUC-MSCs) on proliferation, function, CD4+ SLE patients were assessed elucidate pathogenesis therapeutic mechanism hUC-MSCs based reprogramming. Methods: The clinical...