A5100380347- Bladder and Urothelial Cancer Treatments
- Tissue Engineering and Regenerative Medicine
- Lung Cancer Treatments and Mutations
- Urinary and Genital Oncology Studies
- Phytochemistry and Biological Activities
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Biological and pharmacological studies of plants
- Bioactive natural compounds
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Metabolomics and Mass Spectrometry Studies
- Chronic Myeloid Leukemia Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Xijing Hospital
2025
Air Force Medical University
2025
Shanghai Jiao Tong University
2025
Songjiang District Central Hospital
2025
Institute of Medical Biology
2025
Academy of Medical Sciences
2025
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2022-2024
Affiliated Hospital of Southwest Medical University
2024
Sichuan University
2024
ABSTRACT Background The clinical implications of different EML4‐ALK fusion variants remain poorly elucidated in the era second‐generation ALK inhibitors. Methods This was a retrospective cohort study, wherein patients diagnosed with locally advanced or metastatic non‐small cell lung cancer harboring were stratified into two cohorts based on their first‐line treatment: Cohort 1 received alectinib, while 2 crizotinib. Statistical analysis employed to investigate impact and TP53 status efficacy...
Three unique pyrano[4,3-c][2]benzopyran-1,6-dione derivatives and a new furo[3,2-c]pyran-4-one, named phelligridins C-F (2-5), together with hispolon (8), (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one (9), 4-hydroxybenzaldehyde, protocatechualdehyde, syringic acid, protocatechuic caffeic isoergosterone, octadecyl ferulate were isolated identified from the ethanolic extract of Phellinus igniarius. Their structures determined by spectroscopic methods including IR, MS, 1D 2D NMR experiments. The...
Aims To characterise the mutational profiles of poorly differentiated thyroid carcinoma (PDTC) and anaplastic (ATC) to identify markers with potential diagnostic, prognostic therapeutic significance. Methods results Targeted next‐generation sequencing a panel 18 carcinoma‐related genes was performed on tissue samples from 41 PDTC 25 ATC patients. Genetic alterations their correlations clinicopathological factors, including survival outcomes, were also analysed. Our showed that had...
Polypharmacology is a promising paradigm in modern drug discovery. Herein, we have discovered series of novel PI3K and HDAC dual inhibitors which the hydroxamic acid moiety as zinc binding functional group was introduced to quinazoline-based pharmacophore through an appropriate linker. Systematic structure–activity relationship studies resulted lead compounds 23 36 that simultaneously inhibited with nanomolar potencies demonstrated favorable antiproliferative activities. Compounds...
Against tumor-dependent metabolic vulnerability is an attractive strategy for tumor-targeted therapy. However, inhibitors are limited by the drug resistance of cancerous cells due to their plasticity and heterogeneity. Herein, choline metabolism was discovered spatially resolved metabolomics analysis as which highly active in different cancer types, a choline-modified small molecule-drug conjugates (SMDCs) design developed fool tumor into indiscriminately taking chemotherapy drugs targeted...
The mechanisms of action natural products and the identification their targets have long been a research hotspot. Ganoderic acid A (GAA) is earliest most abundant triterpenoids discovered in Ganoderma lucidum. multi-therapeutic potential GAA, particular its anti-tumor activity, has extensively studied. However, unknown associated pathways together with low limit in-depth compared to other small molecule anti-cancer drugs. In this study, GAA was modified at carboxyl group synthesize series...
Abstract Background Renal interstitial fibrosis (RIF) is a progressive, irreversible terminal kidney disease with poor prognosis and high mortality. Angiopoietin-like 4 (ANGPTL4) known to be associated in various organs, but its impact on the RIF process remains unclear. This study aimed elucidate role underlying mechanisms of ANGPTL4 progression RIF. Methods In vivo, chronic (CKD) rat model renal was established via intragastric administration adenine at different time points (4 6 weeks)....
We herein report a new compound: 10-chloromethyl-11-demethyl-12-oxo-calanolide A (20, EC50 = 7.4 nM, SI 1417), which demonstrates druggable profile with 32.7% oral bioavailability in rat, tolerated single dose toxicity mice, and especially the feature of highly efficient suppression wild-type HIV-1 Y181C mutant at an nM 0.46 respectively.
The development of improved or targeted drugs that discriminate between normal and tumor tissues is the key therapeutic issue in cancer research.However, an analytical method with a high accuracy sensitivity to achieve quantitative assessment targeting anticancer even intratumor heterogeneous distribution these at early stages drug research major challenge.Mass spectrometry imaging label-free molecular technique provides spatial-temporal information on metabolites organisms, its application...
Background: Pin1 is a member of the evolutionarily conserved peptidyl-prolyl isomerase (PPIase) family proteins. Following phosphorylation, Pin1-catalyzed prolyl-isomerization induces conformational changes, which serve to regulate function many phosphorylated proteins that play important roles during oncogenesis. Thus, inhibition provides unique means disrupting oncogenic pathways and therefore represents an appealing target for novel anticancer therapies. Methods: As between yeast humans,...
Three new compounds were isolated from the stems of Dendrobium candidum: (S)-3,4,4′-trihydroxy-5,α-dimethoxybibenzyl (1), named dendrocandin C; (S)-3,4,4′-trihydroxy-5-methoxy-α-ethoxybibenzyl (2), D; and 3,3′,4,4′-tetrahydroxy-5-methoxybibenzyl (3), E. Their structures elucidated by 1D- 2D-NMR spectroscopy mass spectroscopy. The exhibited potent antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging test, with IC50 values 34.2, 34.5, 15.6 μM for 1, 2, 3,...
Sixteen new neolignans and lignans (1–16), together with 12 known analogues, have been isolated from an ethanol extract of the bark Machilus robusta. Compounds 1 2 showed activity against HIV-1 replication in vitro, IC50 values 2.52 2.01 μM, respectively. At 10 6, 8, 9 reduced dl-galactosamine-induced hepatocyte (WB-F344 cells) damage, could additionally attenuate rotenone-induced PC12 cell damage. The compounds (−)-pinoresinol (17) (+)-lyoniresinol (18) were active serum deprivation induced
Helicobacter pylori infection (HPI) is a prevalent infectious disease associated with gastric ulcer, cancer, and many nongastrointestinal disorders. To identify genes that may serve as microbial markers for HPI, we performed shotgun metagenomic sequencing of fecal samples from 313 Chinese volunteers who had undergone C14 breath test. Through comparing differences in intestinal community structure between H. pylori-positive pylori-negative individuals, identified 58 HPI-associated species (P...
To investigate the clinical characteristics and survival outcomes of patients with malignant transformation arising from ovarian mature cystic teratoma (MT-MCT).This retrospective study included MCTs at Peking Union Medical College Hospital (PUMCH) during 1990.01-2020.12. When pathologic histology was MT-MCT, detailed information collected.Overall, 7229 MCT 22 MT-MCT were enrolled. The rate all 0.30%. Most 51 (21-75) years old, tumor mass size 10 (3-30) cm. typical symptoms mainly abdominal...
Metabolic perturbation score-based mass spectrometry imaging (MPS-MSI) is proposed to reveal the spatially resolved functional metabolic response associated with disease progression or drug action including metabolism pathways, species, biofunction, biotransformation. The MPS-MSI enables exploration of therapeutic adverse effects, regional heterogeneous responses treatment, possible molecular mechanisms, and even potential targets. was demonstrated be a promising tool not only for efficacy...
ABSTRACT Antiviral effectors and cytokines are critical components of host innate immunity. However, the regulatory mechanisms governing roles these molecules in host–virus interactions still unclear. Although long non-coding RNAs (lncRNAs) have been recognized as key players various biological processes, their involvement complement system antiviral defenses remains to be explored. In this study, we discovered a novel, unannotated lncRNA, called DARVR. DARVR was found an intergenic lncRNA...
The present study was performed to investigate the effect of bicyclol, a synthetic anti-hepatitis drug with anti-oxidative and anti-inflammatory properties, on anti-tuberculosis (anti-TB) drug-induced liver injury related mechanisms in rats. Bicyclol given rats by gavage 2 h before oral administration an anti-TB once day for 30 days. Liver evaluated biochemical histopathological examinations. Lipid peroxidation, mitochondrial function, activity antioxidants were measured spectrophotometric...
Tumor-infiltrating immune cells are closely related to the prognosis of bladder cancer.Analysis tumor infiltrating is usually based on immunohistochemical analysis.Since many cell marker proteins not specific for different cells, which may induce misleading or incomplete.CIBERSORT an algorithm estimate types in a mixed population using gene expression data.In this study, CIBERSORT was used identify infiltration signatures.The profiles, mutation data, and clinical data were collected from The...
The differential diagnosis of mucoepidermoid carcinoma (MEC) from neoplasm undergoing mucinous features brings more pitfalls to pathologists. Combining specific