A5102718324- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Natural Compounds in Disease Treatment
- Plant chemical constituents analysis
- Natural Compound Pharmacology Studies
- Traditional and Medicinal Uses of Annonaceae
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Essential Oils and Antimicrobial Activity
- Phytochemical compounds biological activities
- Magnolia and Illicium research
- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemical Studies and Bioactivities
- Phytochemistry and Bioactive Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Psidium guajava Extracts and Applications
- Sesquiterpenes and Asteraceae Studies
- Bioactive natural compounds
- Chemical synthesis and alkaloids
- Synthesis and Biological Activity
- Bioactive Compounds and Antitumor Agents
- Synthesis of Organic Compounds
- Ziziphus Jujuba Studies and Applications
- Beetle Biology and Toxicology Studies
- Genomics, phytochemicals, and oxidative stress
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2015-2017
Xinjiang Institute of Materia Medica
2015-2017
State Council of the People's Republic of China
2015-2017
Tianjin University of Traditional Chinese Medicine
2014
Jiangxi University of Traditional Chinese Medicine
2005-2010
Ten new carbazole alkaloids, claulansines A–J (1–10), and seven known analogues (11–17) were isolated from the stems of Clausena lansium. Their structures established on basis extensive spectroscopic analyses, their absolute configurations determined by CD experiments computational methods. Screening results indicated that compounds 1, 6, 8–10, 13, 14, 17 showed selective neuroprotective effects at concentration 10 μM.
Three novel sesquiterpenoid-based meroterpenoids of psidials A−C (1−3) have been isolated from the leaves Psidium guajava L. Their complete structures were elucidated by spectral and chemical methods, that 1 was confirmed single-crystal X-ray diffraction analysis. Psidial B (2) C (3) represented new skeleton 3,5-diformylbenzyl phloroglucinol-coupled sesquiterpenoid. A possible biosynthetic pathway for 2−3 postulated. showed activity to enzyme PTP1B in 10 μM.
Guajavadimer A (1), a dimeric sesquiterpene-based meroterpenoid which possessed an unprecedented two caryophyllenes, benzylphlorogulcinol, and flavonone-fused complicated stereochemical skeleton, was isolated from the leaves of Psidium guajava L. Its structure absolute configuration were elucidated on basis spectroscopic data X-ray crystallography. (1) showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells.
Twelve new dihydroagarofuran sesquiterpene polyol esters, triptersinines A–L (1–12), and eight known pyridine alkaloids were isolated from the leaves of Tripterygium wilfordii. Their structures elucidated on basis spectroscopic analyses, including UV, IR, NMR experiments (1H–1H COSY, NOESY, HSQC, HMBC). Furthermore, in an vitro bioassay, compounds 1, 9, 11, 13, 14, 18 showed moderate inhibitory effects nitric oxide production LPS-induced macrophages at 5 μM; all inactive when tested against...
The methanol fraction of an ethanolic extract from the roots Polygala tenuifolia Willd. showed antagonistic action on neurotoxicity induced by glutamate and serum deficiency in PC12 cells. Bioassay-guided fractionation led to isolation six new triterpenoid saponins, onjisaponins V - Z, Vg ( 1 6), together with ten known saponins 7 16). structures 6 were elucidated spectroscopic chemical methods. Screening results indicated that compounds 16 neuroprotective effects against at concentration 10...
Magterpenoid A (1), possessing a rare 4,6,11-trioxatricyclo[5.3.1.01,5]undecane framework with an irregular monoterpenoid moiety, magterpenoid B (2), unprecedented 6/6/6/6 polycyclic skeleton, and C (3), novel terpenoid quinone C6–C3 unit, were isolated from the bark of Magnolia officinalis var. biloba. Plausible biogenetic pathways 1-3 are presented. Compounds 1 3 exhibited significant PTP1B inhibitory activities IC50 values 1.44 0.81 μM, respectively.
Twelve new A,D-seco-limonoids, clauemargines A–L (1–12), and three known analogues were isolated from the stems of Clausena emarginata. The absolute configurations 1 5 confirmed by X-ray crystallography ECD spectroscopy, respectively. Compounds 1, 2, 8–10, 13 showed moderate inhibitory effects on LPS-induced NO production (IC50 values < 10 μM).
Six new alkaloid glycosides (<bold>1–6</bold>), along with two quinoline alkaloids (<bold>7–8</bold>), were obtained from the stems of <italic>Clausena lansium</italic>. Compounds <bold>4</bold>, <bold>6</bold>, <bold>9</bold>, <bold>17</bold> and <bold>18</bold> showed moderate inhibitory effects on LPS-induced NO production in murine microglial BV2 cells.
Dracaena, a remarkably long-lived and slowly maturing species of plant, is world famous for its ability to produce dragon's blood, precious traditional medicine used by different cultures since ancient times. However, there no detailed high-quality genome available this at present; thus, the molecular mechanisms that underlie important traits are largely unknown. These factors seriously limit protection regeneration rare endangered plant resource. Here, we sequenced assembled Dracaena...
Tripterlides A–F are new abietane derivatives, obtained from <italic>Tripterygium wilfordii</italic>. <bold>1–4</bold> novel 14(13 → 12),18(4 3)-<italic>diabeo</italic>-abietanoids possessing a 6/6/5 tricyclic ring system.
Thirteen dihydroagarofuran derivatives, including 12 new sesquiterpenoid esters and one known alkaloid, were obtained from the leaves of Tripterygium wilfordii. Spectroscopic techniques ECD method used for structure elucidation compounds. The structures compounds 1 8 confirmed by single-crystal X-ray crystallographic analyses. Compounds 8, 9, 11, 12, 13 increased cell viability okadaic acid treated PC12 cells 60.4 ± 23.0% to 72.4 14.1, 71.5 11.5, 75.7 15.6, 81.2 13.1, 86.2 25.5% at 10 μM,...