A5102879913- Analytical chemistry methods development
- Electrochemical Analysis and Applications
- Fuel Cells and Related Materials
- Electrocatalysts for Energy Conversion
- Natural product bioactivities and synthesis
- Mercury impact and mitigation studies
- Traditional Chinese Medicine Analysis
- Magnolia and Illicium research
- Radioactive element chemistry and processing
- Extraction and Separation Processes
- Chromatography in Natural Products
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Mass Spectrometry Techniques and Applications
- Advancements in Solid Oxide Fuel Cells
- Arsenic contamination and mitigation
- Heavy Metals in Plants
- Analytical Chemistry and Chromatography
- Oxidative Organic Chemistry Reactions
- Ion-surface interactions and analysis
- Chemokine receptors and signaling
- Food Quality and Safety Studies
- Heavy metals in environment
- Medicinal Plant Pharmacodynamics Research
Peking University
2015-2025
Xuzhou Medical College
2025
Northeast Forestry University
2024
Shaanxi University of Chinese Medicine
2011-2024
North China University of Water Resources and Electric Power
2024
Wuhan Polytechnic University
2014-2023
Zhengzhou University
2023
Shenyang Jianzhu University
2009-2021
Science Exchange (United States)
2020
State Key Laboratory of Natural and Biomimetic Drugs
2016-2017
Molecular analyses of the chemokine fractalkine and its receptor CX3C-R1 in rat brain have revealed a striking polarization: is expressed constitutively neurons up-regulated by TNF-alpha IL-1beta astrocytes. Expression specific receptor, CX3C-R1, restricted to astrocytes microglia. We analyzed functional correlates this expression demonstrate that induces microglial cell migration activation. However, activity on may also be highly relevant inducing astrocyte-microglia interactions through...
Chemokines play a central role in immune and inflammatory responses. It has been observed recently that certain viruses have evolved molecular piracy mimicry mechanisms by encoding synthesizing proteins interfere with the normal host defense response. One such viral protein, vMIP-II, encoded human herpesvirus 8, identified vitro antagonistic activities against CC CXC chemokine receptors. We report here vMIP-II additional activity CX3CR1, receptor for fractalkine. To investigate potential...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting both upper and lower motor neurons (MNs) with large unmet medical needs. Multiple pathological mechanisms are considered to contribute the progression of ALS, including neuronal oxidative stress mitochondrial dysfunction. Honokiol (HNK) has been reported exert therapeutic effects in several neurologic models ischemia stroke, Alzheimer's Parkinson's disease. Here we found that honokiol also exhibited...
Fractalkine is an endothelial cell-derived CX3C chemokine that chemotactic mainly to mononuclear cells. was induced in rat aortic cells (RAEC) by interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and lipopolysaccharide (LPS) transcriptionally translationally. This induction correlated with increased NF-kappaB DNA binding activity as determined gel mobility shift assay. Supershift assays revealed the subunits p50 p65 were responsible for kappaB binding. Accordingly, we...
Zika virus (ZIKV) infection during pregnancy leads to severe congenital syndrome, which includes microcephaly and other neurological malformations. No therapeutic agents have, so far, been approved for the treatment of ZIKV in humans; as such, there is a need continuous effort develop effective safe antiviral drugs treat ZIKV-caused diseases. After screening natural product library, we have herein identified four products with anti-ZIKV activity Vero E6 cells, including gossypol, curcumin,...
Polyporus umbellatus is a well-known and important medicinal fungus in Asia. Its polysaccharides possess interesting bioactivities such as antitumor, antioxidant, hepatoprotective immunomodulatory effects. A qualitative quantitative method has been established for the analysis of 12 monosaccharides comprising based on high-performance liquid chromatography coupled with electrospray ionization-ion trap-time flight-mass spectrometry. The hydrolysis conditions were optimized by orthogonal...
OB (leptin) has been identified as a factor that suppresses appetite and stimulates metabolism. Attention focused on the hypothalamus its potential site of action, but could also act other brain regions. In addition, paradox high levels in obese humans remains unresolved. Here we show mice both long short form receptor are expressed not only amygdala pituitary. Recombinant murine elicited release corticotropin-releasing from superfused slice preparations containing or amygdala. Because...