A5101534427- Agriculture Sustainability and Environmental Impact
- Ruminant Nutrition and Digestive Physiology
- Reproductive Physiology in Livestock
- Genetic and phenotypic traits in livestock
- Agricultural Economics and Policy
- Eicosanoids and Hypertension Pharmacology
- Pulmonary Hypertension Research and Treatments
- Rheumatoid Arthritis Research and Therapies
- Effects of Environmental Stressors on Livestock
- Protease and Inhibitor Mechanisms
- Livestock Management and Performance Improvement
- Ginseng Biological Effects and Applications
- TGF-β signaling in diseases
- Natural Compounds in Disease Treatment
- Cancer-related Molecular Pathways
- Industrial Vision Systems and Defect Detection
- Crystal structures of chemical compounds
- Cholinesterase and Neurodegenerative Diseases
- Carcinogens and Genotoxicity Assessment
- Cell Adhesion Molecules Research
- Advancements in Photolithography Techniques
- Lung Cancer Treatments and Mutations
- Sphingolipid Metabolism and Signaling
- Signaling Pathways in Disease
- Autoimmune and Inflammatory Disorders Research
Jilin University
2017-2024
Qinhuangdao Second Hospital
2022
University of Wisconsin–Madison
2015-2020
China Pharmaceutical University
2017
University of Kentucky
2013-2016
Peking Union Medical College Hospital
2014-2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2015
Harbin Medical University
2008-2014
To compare the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with methotrexate (MTX) in treatment active rheumatoid arthritis (RA).Design: a multicentre, open-label, randomised controlled trial. All patients were assessed by trained investigators who unaware therapeutic regimen.207 RA randomly allocated (1:1:1) to MTX 12.5 mg once week, or TwHF 20 three times day, two combination. At week 12, if reduction 28-joint count Disease Activity Score (DAS28) was <30% monotherapy...
In this study, we designed two series of novel anthraquinone-based benzenesulfonamide derivatives and their analogues as potential carbonic anhydrase inhibitors (CAIs) evaluated inhibitory activities against off-target human II (hCA II) isoform tumor-associated IX IX) isoform. Most these compounds exhibited good hCA IX. The that the best inhibition were further studied MDA-MB-231, MCF-7, HepG2 cell lines under hypoxic normoxic conditions. Additionally, exhibiting antitumor activity subjected...
A survey regarding crop enterprise management, forages cost of production, dairy cattle management including reproductive housing, heat abatement, body condition scoring, nutrition, grouping strategies, and income over feed performance, was carried out from December 2016 to January 2018 on 50 farms by the Department Animal Science, Food Nutrition Università Cattolica del Sacro Cuore (Piacenza, Italy). total 41 herds (82%) completed survey. Average herd size 327 ± 162 lactating cows with...
20(S)-Rh2 is a ginsenoside isolated from Panax ginseng, which exhibits anti-cancer activities on various human cancer cells. A novel derivative, 2-Deoxy-Rh2 was synthesized and hybridized with protopanaxadiol 2-deoxy-glucose in an attempt to enhance the anticancer activity. Through screening antitumor effect against cell lines by MTT assay, especially resulted concentration-dependent time-dependent inhibition of viability MCF-7 breast Multiple methods were used explore cellular molecular...
Arterial thrombosis and its related diseases are major healthcare problems worldwide.Blebbistatin is an inhibitor of myosin II, which plays important role in thrombosis.The aim our study to explore the effect potential mechanism blebbistatin on arterial thrombosis.A ferric chloride (FeCl3) solution at a concentration 5% was used induce carotid artery mice.Immunohistochemistry immunofluorescence staining were detect expression or activation non-muscle heavy chain IIA (NMMHC IIA), tissue...
The purpose of this study was to investigate the effects sacubitril/valsartan on right ventricular (RV) function in patients with pulmonary hypertension (PH) due heart failure reduced ejection fraction (HFrEF). We prospectively enrolled HFrEF-induced PH admitted Department Cardiology between August 2018 and December 2019. Patients were randomized receive oral treatment or enalapril. Epidemiological data recorded before treatment. Echocardiography performed at admission 6 months follow-up,...
It has been previously reported by us that hypoxia activates lung 15-lipoxygenase (15-LO), which catalyzes arachidonic acid to 15-hydroxyeicosatetraenoic (15-HETE), leading the constriction of pulmonary artery (PA). Rho-associated serine/threonine kinase (ROK), a downstream effector small GTPase RhoA may be modulated G-protein and tyrosine kinase, plays an important role in smooth muscle contraction. However, whether 15-HETE induced PA vasoconstriction involves Rho/ROK pathway remains...
Cathepsin B is a lysosomal cysteine protease involved in many diseases. The present research demonstrates that derivatives of epoxysuccinyl-peptide are effective and selective cathepsin inhibitors. We synthesized series based on the well-known inhibitor E64d. Specifically, we substituted 2-methylpropane group at R1 position E64d with sulfane, such as ethyl(methyl) sulfane or benzyl(methyl) sulfane. also designed library molecules various substituents R2 to replace 2-methylbutane. By studying...
Transforming growth factor type 1 receptor (ALK5) is kinase associated with a wide variety of pathological processes, and inhibition ALK5 good strategy to treat many kinds cancer fibrotic diseases. Recently, series compounds have been synthesized as inhibitors. However, the study their selectivity against other potential targets remains elusive. In this research, data-set inhibitors were collected studied based on combination 2D-QSAR, molecular docking dynamics simulation. The quality QSAR...
Researchers occasionally use a single photomask to create stacked structure with identical patterns. This method is cost-effective but also challenging for precise overlay control, due the lack of coupled marks between successive layers. In this paper, an innovative approach has been developed address problem. By shifting exposure field specific offset, outer mark previous layer and inner current are aligned same coordinate position, allowing accurate measurement error. The raw values then...
In the title compound, [Cu(C(17)H(19)FN(3)O(3))(2)], Cu(II) atom (site symmetry ) exhibits a slightly distorted CuO(4) square-planar geometry defined by two bidentate O,O'-bonded 1-ethyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxyl-ate (perfloxacinate) anions.
We developed a nonlinear programming model that selects the optimal cropping plan and diet formulation to maximize farm income over feed cost (IOFC) in representative 200-lactating cow, 100-ha south-central Wisconsin farm. Nutrition requirements for 6 cow-groups were formulated according National Research Council equations. Then, selected group production level toward maximum IOFC, which included milk surplus sale, cost, purchasing cost. Yearly farm-produced feed, forage quality (NDF), costs...