A5101713315- Photoacoustic and Ultrasonic Imaging
- Optical Coherence Tomography Applications
- Nanoplatforms for cancer theranostics
- Advanced Fluorescence Microscopy Techniques
- Neuroscience and Neural Engineering
- Congenital heart defects research
- Photodynamic Therapy Research Studies
- Pancreatic function and diabetes
- Mechanical and Optical Resonators
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Computational Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Thermography and Photoacoustic Techniques
- Smart Grid and Power Systems
- Image Processing Techniques and Applications
- Metamaterials and Metasurfaces Applications
- Power Systems and Technologies
- Biofuel production and bioconversion
- Cancer Research and Treatments
- Plasmonic and Surface Plasmon Research
- Extracellular vesicles in disease
- Advanced MEMS and NEMS Technologies
- Microbial Metabolic Engineering and Bioproduction
- Gold and Silver Nanoparticles Synthesis and Applications
- Analytical Chemistry and Sensors
Michigan State University
2018-2024
China Telecom (China)
2023-2024
State Grid Corporation of China (China)
2023-2024
China University of Mining and Technology
2024
Harbin Medical University
2010-2024
First Affiliated Hospital of Harbin Medical University
2024
Xiamen University of Technology
2024
British Council
2021
King Mongkut's Institute of Technology Ladkrabang
2021
Alexander von Humboldt Foundation
2021
Abstract Pluripotent stem cell-derived organoids can recapitulate significant features of organ development in vitro. We hypothesized that creating human heart by mimicking aspects utero gestation (e.g., addition metabolic and hormonal factors) would lead to higher physiological anatomical relevance. find produced using this self-organization-driven developmental induction strategy are remarkably similar transcriptionally morphologically age-matched embryonic hearts. also show they several...
Near-infrared confocal microendoscopy is a promising technique for deep in vivo imaging of tissues and can generate high-resolution cross-sectional images at the micron-scale. We demonstrate use dual-axis (DAC) near-infrared fluorescence microendoscope with 5.5-mm outer diameter obtaining clinical human colorectal mucosa. High-speed two-dimensional en face scanning was achieved through microelectromechanical systems (MEMS) scanner while micromotor used adjusting axial focus. In patients are...
A major contributing cause to breast cancer related death is metastasis. Moreover, metastasis often shows little symptoms until a large area of the organs occupied by metastatic cells. Breast multimodal imaging attractive since it integrates advantages from several modalities, enabling more accurate detection. Glycoprotein CD44 overexpressed on most cells and primary cell surface receptor for hyaluronan (HA). To facilitate diagnosis, we report an indocyanine green (ICG) HA conjugated iron...
Raman spectroscopic imaging has shown great promise for improved cancer detection and localization with the use of tumor targeting surface enhanced scattering (SERS) nanoparticles. With ultrasensitive multiplexing capabilities that SERS to offer, scientists have been investigating several clinical applications could benefit from this unique strategy. Recently, there a push develop new image-guidance tools surgical resection help surgeons sensitively specifically identify margins in real...
We present an integrated monolithic, electrostatic 3D MEMS scanner with a compact chip size of 3.2 × 2.9 mm 2 .Use parametric excitation near resonance frequencies produced large optical deflection angles up to ± 27° and 28.5° in the X-and Y-axes displacements 510 μm Z-axis low drive voltages at atmospheric pressure.When packaged dual axes confocal endomicroscope, horizontal vertical cross-sectional images can be collected seamlessly tissue field-of-view >1 1 0.41 , respectively, 5 frames/sec.
Ultra-flexible, highly-conductive and fully-transparent μECoG electrode arrays made of PEDOT:PSS–ITO–Ag–ITO on thin parylene C successfully achieved neurophysiology recording.
High frequency large scanning angle electrostatically actuated microelectromechanical systems (MEMS) mirrors are used in a variety of applications involving fast optical scanning. A 1-D parametrically resonant torsional micromirror for use biomedical imaging is analyzed here with respect to operation by duty-cycled square waves. Duty-cycled wave excitation can have significant advantages practical mirror regulation and/or control. The mirror's nonlinear dynamics under such Hill's equation...
We demonstrate vertical cross-sectional (XZ-plane) images of near-infrared (NIR) fluorescence with a handheld dual axes confocal endomicroscope that reveals specific binding Cy5.5-labeled peptide to pre-malignant colonic mucosa. This view is perpendicular the tissue surface, and similar used by pathologists. The scan head 10 mm in outer diameter (OD), integrates one dimensional (1-D) microelectromechanical systems (MEMS) X-axis scanner bulky lead zirconate titanate (PZT) based Z-axis...
Over the last decade, optical fiber-based forms of microscopy and endoscopy have extended realm applicability for many imaging modalities. Optical modalities permit use remote illumination sources enable flexible supporting creation portable hand-held instrumentations to interrogate within hollow tissue cavities. A common challenge in development such devices is design integration miniaturized mechanical components. Until recently, microelectromechanical systems (MEMS) sensors actuators been...
Progress toward early diagnosis of cancer would have significant clinical benefits in reducing mortality or prolonging life patients; thus, there is an important unmet need to image cellular features vivo and real time correlate pathological symptoms underlying cells responsible for such symptoms. In this paper, we describe a review microelectromechanical systems scanners-based endoscopic optical coherence tomography, confocal, two-photon, photoacoustic microscopy imaging. These advanced...
In this paper, a threshold signal detector is proposed to improve the state estimation accuracy of an extended Kalman filter (EKF) and validated experimentally with microelectromechanical system electrostatic microscanner. A first-order derivative Gaussian used detect locate rapid changes in voltage caused by crossing angle determined maximum overlap capacitive electrodes. The event-triggered measurement update step EKF provide intermittent but more accurate measurements than those sensor's...
Transplantation of human-induced pluripotent stem cell (hiPSC)-derived islet organoids is a promising replacement therapy for type 1 diabetes (T1D). It important to improve the efficacy transplantation by identifying new sites with high vascularization and sufficient accommodation support graft survival capacity oxygen delivery.
We present software-based methods for automatic phase control and mosaicing high-speed, Lissajous-scanned images. To achieve imaging speeds fast enough mosaicing, we first increase the image update rate tenfold from 3 to 30 Hz, then vertically interpolate each sparse in real-time eliminate fixed pattern noise. validate our by fluorescent beads automatically maintaining over course of one hour. mouse brain tissues at varying rates compare resulting mosaics. Using reconstructed data as...
Abstract Congenital heart defects (CHD) constitute the most common birth defect in humans, affecting approximately 1% of all live births. Our ability to understand how these disorders originate is hindered by our limited model complexity human vitro. There a pressing need develop more faithful organ-like platforms recapitulating complex vivo phenotypes study development and disease Here we report novel method generate organoids self-assembly using pluripotent stem cells. fully defined,...
Breast cancer is the leading cause of cancer-associated deaths among women. Techniques for non-invasive breast detection and imaging are urgently needed. Multimodality attractive since it can integrate advantages from several modalities, enabling more accurate detection. In order to accomplish this, indocyanine green (ICG)-conjugated superparamagnetic iron oxide nanoworm (NW-ICG) has been synthesized as a contrast agent. When evaluated in spontaneous mouse model, NW-ICG gave large tumor...
We describe a 2-D microelectromechanical systems (MEMS) scanner for handheld multispectral confocal microscope early detection and diagnosis of cervical cancer. This paper is an expansion work originally reported in the Proceedings IEEE International Conference on Optical MEMS Nanophotonics 2012. The fabrication process has been designed to improve performance dual-axis microscopy architecture. Dual-axis achieves comparable transverse depth resolution high numerical aperture (NA) single-axis...
Surface enhanced resonance Raman (SERS) is a powerful optical technique, which can help enhance the sensitivity of spectroscopy aided by noble metal nanoparticles (NPs). However, current SERS‐NPs are often suboptimal, aggregate under physiological conditions with much reduced SERS enhancement. Herein, robust one‐pot method has been developed to synthesize more uniform core diameters 50 nm, applicable both non‐resonant and resonant dyes. The resulting colloidally stable bright, enabling NP...