A5100320327- Diabetes and associated disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Immune Response and Inflammation
- Gut microbiota and health
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
- Liver Diseases and Immunity
- Gastric Cancer Management and Outcomes
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- IL-33, ST2, and ILC Pathways
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Dermatology and Skin Diseases
- Traditional Chinese Medicine Analysis
- Animal Virus Infections Studies
- Diet and metabolism studies
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
Xijing Hospital
2016-2025
Jilin University
2024-2025
Pfizer (United States)
1995-2025
Air Force Medical University
2004-2025
Nanjing Medical University
2024-2025
Center for Global Health
2025
University of Science and Technology of China
2025
Peking Union Medical College Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Ministry of Agriculture and Rural Affairs
2024
Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions people in the developing world. We have sequenced approximately 90 megabase (Mb) genome human filarial parasite Brugia malayi predict 11,500 protein coding genes 71 Mb robustly assembled sequence. Comparative analysis with free-living, model nematode Caenorhabditis elegans revealed that, despite these having maintained little conservation local synteny during 350 million years evolution, they...
The precise roles of B cells in promoting the pathogenesis type 1 diabetes remain undefined. Here, we demonstrate that cell depletion mice can prevent or delay diabetes, reverse after frank hyperglycemia, and lead to development suppress disease. To determine efficacy potential mechanism therapeutic depletion, generated a transgenic NOD mouse expressing human CD20 (hCD20) on cells. A single cycle treatment with an antibody specific for hCD20 temporarily depleted significantly delayed and/or...
Alveolar epithelial cell damage is an important determinant of the severity acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, molecular mechanisms alveolar death during development ALI/ARDS remain unclear. In this study, we explore role miR-29a-3p in and its mechanism. Plasma samples were collected from healthy controls ARDS patients. Mice intratracheally instilled with lipopolysaccharide (LPS) to establish injury. N6-adenosine (m6A) quantification, RNA-binding...
Pore-forming Gasdermin protein-induced pyroptosis in tumor cells promotes anti-tumor immune response through the release of pro-inflammatory cytokines and immunogenic substances after cell rupture. However, endosomal sorting complexes required for transport (ESCRT) III-mediated membrane repair significantly diminishes by repairing subsequently removing gasdermin pores. Here, we show that blocking calcium influx-triggered ESCRT III-dependent a biodegradable nanoparticle-mediated sustained...
Abstract Traditionally, lactate has been considered a ‘waste product’ of cellular metabolism. Recent findings have shown that is substance plays an indispensable role in various physiological functions and contributes to energy metabolism signal transduction during immune inflammatory responses. The discovery lactylation further revealed the regulating processes. In this review, we comprehensively summarize paradoxical characteristics microenvironment highlight pivotal roles homeostasis,...
T cells play an important role in the pathogenesis of diabetes nonobese diabetic (NOD) mouse. CD8 cytotoxic cell lines and clones were generated from lymphocytic infiltrate islets Langerhans young (7-wk-old). NOD mice by growing them on (NOD x B6-RIP-B7-1)F1 islets. These proliferate specifically to kill vitro. The are restricted H-2Kd, all bear antigen receptor encoded V beta 6. When these adoptively transferred irradiated female NOD, NOD-SCID, CB17-SCID mice, occurs very rapidly, within 10...
The fragile X mental retardation protein (FMRP) is a selective RNA-binding implicated in regulating translation of its mRNA ligands. absence FMRP results syndrome, one the leading causes inherited retardation. Delayed dendritic spine maturation was found patients as well Fmr1 knockout (KO) mice, indicating functional requirement synaptic development. However, biochemical link between deficiency and neuronal impairment during brain development has not been defined. How governs normal synapse...
Vertebrate immune systems contain T cells bearing either alpha beta or gamma delta T-cell antigen receptors (TCRs). perform all well-characterized effector functions, while the biological functions of + remain unclear. Of particular interest is role during epithelial infections, since are commonly abundant within epithelia. Eimeria spp. intracellular protozoa that infect epithelia most vertebrates, causing coccidiosis. This study shows in response to vermiformis, mice lacking display defects...
B-cells are important in the development of type 1 diabetes, but their role is not completely defined. Although produce autoantibodies, these thought to be pathogenic; however, antigen-presenting function postulated critical. To examine relative importance functions B-cells, we have generated nonobese diabetic (NOD) B-cell–deficient mice that express a transgene encoding mutant heavy chain immunoglobulin on cell surface cannot secrete immunoglobulins (mIgs). This allowed us dissect roles...
Both animal model and human studies indicate that commensal bacteria may modify type 1 diabetes (T1D) development. However, the underlying mechanisms by which gut microbes could trigger or protect from are not fully understood, especially interaction of with pathogenic CD8 T cells. In this study, using islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP)–reactive cell receptor NY8.3 transgenic nonobese diabetic mice, we demonstrated MyD88 strongly modulates CD8+...
Schizophrenia is associated with widespread cognitive impairments. Although deficits are one of the factors most strongly functional outcome in schizophrenia, current treatment strategies largely fail to ameliorate these To develop more efficient patients a better understanding pathogenesis needed. Accumulating evidence indicates that genetic risk schizophrenia may contribute dysfunction.To identify genomic regions jointly influencing and domains reaction time verbal-numerical reasoning, as...
Significance Our study demonstrated that the nucleotidebinding oligomerization domain, leucine-rich repeat and pyrin domaincontaining protein 3 (NLRP3) pathway plays an important role in type 1 diabetes (T1D) using a mouse model. NLRP3 is critical for chemokine receptors CCR5 CXCR3 expression on T cells, influencing pathogenic T-cell migration to islets. It also affects chemokines CCL5 CXCL10 islets, preventing cells from infiltration. Targeting this may be useful prevention treatment of T1D...
We recently showed that forkhead-box class O1 (FoxO1) activation protects against high glucose-induced injury by preventing mitochondrial dysfunction in the rat kidney cortex. In addition, FoxO1 has been reported to mediate putative kinase 1 (PINK1) transcription and promote autophagy response oxidative stress murine cardiomyocytes. this study, we ascertained whether overexpressing cortex reverses preestablished diabetic nephropathy animal models. The effect of on mitophagy signaling...
Autoimmune hepatitis (AIH) in humans is a severe inflammatory liver disease characterized by interface hepatitis, the presence of circulating autoantibodies, and hyper-gammaglobulinemia. There are two types AIH, type 1 (AIH-1) 2 (AIH-2), distinct autoimmune serology. Patients with AIH-1 positive for anti-smooth muscle and/or antinuclear whereas patients AIH-2 have anti-liver kidney microsomal cytosol autoantibodies. Cytochrome P4502D6 antigenic target 1, formiminotransferase cyclodeaminase...
Abstract Thrombosis and its complications are the leading cause of death in patients with diabetes. Metformin, a first-line therapy for type 2 diabetes, is only drug demonstrated to reduce cardiovascular diabetic patients. However, whether metformin can effectively prevent thrombosis potential mechanism action unknown. Here we show, prevents both venous arterial no significant prolonged bleeding time by inhibiting platelet activation extracellular mitochondrial DNA (mtDNA) release....
Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and intracranial volume (ICV). However, little known about the underlying etiology of these alterations. Here, we explored whether structure SCZ share genetic risk factors. Using conditional false discovery rate (FDR) analysis, integrated genome-wide association study (GWAS) data on (n = 82315) GWAS 7 ICV 11840). By conditioning FDR overlapping associations, this statistical approach increases power to discover...
OBJECTIVE B lymphocytes play an important role in the immunopathogenesis of autoimmune diabetes. We hypothesized that altered B-cell subset phenotype is associated with RESEARCH DESIGN AND METHODS Patients type 1 diabetes (T1D) (n = 81), latent adults (LADA) 82), or 2 (T2D) 95) and healthy control subjects 218) normal glucose tolerance (NGT) were recruited. determined percentage circulating B-lymphocyte subsets, including CD19+CD23−CD21+ (marginal zone [MZB]), CD19+CD23+CD21− (follicular...