A5055906677- RNA Interference and Gene Delivery
- Ginseng Biological Effects and Applications
- Metabolomics and Mass Spectrometry Studies
- Phytochemicals and Antioxidant Activities
- Analytical Chemistry and Chromatography
- Immunotherapy and Immune Responses
- Advanced Chemical Sensor Technologies
- Antimicrobial Peptides and Activities
- Fatty Acid Research and Health
- Advanced biosensing and bioanalysis techniques
- Food Quality and Safety Studies
- Morinda citrifolia extract uses
- Microbial Metabolism and Applications
- Fungal Biology and Applications
- Seaweed-derived Bioactive Compounds
- MicroRNA in disease regulation
- Phytochemical Studies and Bioactivities
- HIV/AIDS drug development and treatment
- Aquaculture disease management and microbiota
- vaccines and immunoinformatics approaches
- Helicobacter pylori-related gastroenterology studies
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Tea Polyphenols and Effects
- Sexual Differentiation and Disorders
Sichuan University
2013-2025
State Key Laboratory of Biotherapy
2019-2024
Jinan University
2024
Ludong University
2021-2024
Xinjiang Normal University
2024
Shanxi Medical University
2024
Academy of State Administration of Grain
2024
Tianjin Chengjian University
2023
Henan University of Science and Technology
2023
Inner Mongolia Agricultural University
2023
Abstract Thrombosis and its complications are the leading cause of death in patients with diabetes. Metformin, a first-line therapy for type 2 diabetes, is only drug demonstrated to reduce cardiovascular diabetic patients. However, whether metformin can effectively prevent thrombosis potential mechanism action unknown. Here we show, prevents both venous arterial no significant prolonged bleeding time by inhibiting platelet activation extracellular mitochondrial DNA (mtDNA) release....
Development of personalized cancer vaccines based on neoantigens has become a new direction in immunotherapy. Two forms have been widely studied: tumor-associated antigen (including proteins, peptides, or tumor lysates)-pulsed dendritic cell (DC) and protein- peptide-adjuvant vaccines. However, different immune modalities may produce therapeutic effects responses when the same is used. Therefore, it necessary to choose more effective neoantigen vaccination method. In this study, we compared...
Abstract In situ vaccination is a desirable strategy for cancer immunotherapy due to its convenience and capacity target tumor antigens. Here, an in nanovaccine based on cationic peptide with cholesterol‐modified, DP7‐C, rationally designed, developed that easy preparate. The includes cocktail small interfering RNAs (siRNAs) immunologic adjuvant CpG ODNs, has synergistic effect the treatment. This can induce cell death, promote antigen presentation relieve immune suppression microenvironment...
The present study investigated the effects of lotus seedpod procyanidins (LSPCs) administered by oral gavage on cognitive deficits and oxidative damage mice at extremely low frequency electromagnetic field (ELF-EMF) exposure (50 Hz, 8 mT, 28 days). results showed that 90 mg kg−1 LSPCs treatment significantly increased body weight compared with ELF-EMF group effectively maintained liver index, thymus kidney index spleen close to normal. A water maze test indicated learning memory abilities...
Abstract Hepatocellular carcinoma (HCC) is one of the most lethal cancers in humans. The inhibition peptidyl‐prolyl cis / trans isomerase (Pin1) gene expression may have great potential treatment HCC. N ‐Acetylgalactosamine (GalNAc) was used to target liver. Cholesterol‐modified antimicrobial peptide DP7 (DP7‐C) acts as a carrier, GalNAc‐siRNA/DP7‐C complex increases uptake GalNAc‐siRNA and escape endosomes hepatocytes. In addition, DP7‐C nanoparticles hydrogel‐assisted GalNAc‐Pin1 siRNA...
, is a widely used medicinal fungus. The polyphenols extracted from this fungus exert antioxidant, anti-inflammatory, and hypoglycemic effects. In study, the fruiting bodies of
The treatment of metastatic lung cancer, a common complication many primary cancers, has historically been significant clinical challenge. Once metastasis occurs, patients' survival is often significantly shortened. Therefore, prevention and metastases an important aspect cancer treatment. In this study, simple, low-toxicity, cholesterol-modified cationic cell-penetrating peptide DP7 (DP7-C), in combination with siDR6 was used for intravenous administration the metastases. Initially,...
Antimicrobial peptides (AMPs) provide a promising strategy against infections involving multidrug resistant pathogens. In previous studies, we designed short 12 amino acid AMP DP7, using machine-learning method based on activity contribution matrix. DP7 shows broad-spectrum antimicrobial activities both in vitro and vivo. Here, aim to investigate the efficacy of Staphylococcus aureus (S. aureus) reveal potential mechanisms. First, by measuring killing kinetics S. comparing these results with...
Bioactive components in Gardenia oil were extracted by ultrasound-assisted extraction, identified and quantified HPLC-DAD/ESI-MS<sup>2</sup> HPLC-DAD analysis.
Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury during which inflammatory responses induce cell apoptosis, necrosis, and fibrosis. Metastasis-associated adenocarcinoma transcript 1 (MALAT1) multiple function long noncoding RNA that was found overexpressed injury. However, the roles MALAT1 in ARDS patients are still unknown.Total extracted from plasma, plasma exosome, peripheral blood mononuclear cells (PBMCs) 65 36 healthy controls. The six candidate miRNAs...
Background: Tribendimidine is a new anthelmintic agent synthesized by Chinese scientists. It broad spectrum with high activity against parasites. However, its disposition and metabolism remain unknown. Objective: To investigate the metabolism, disposition, metabolites of tribendimidine in healthy human volunteers. Methods: Twelve volunteers were chosen after clinical assessment health status laboratory tests. They received single oral doses 400mg enteric-coated tablets. Blood urine samples...
Abstract Peptides with suitable aggregation behavior and electrical properties are potential siRNA delivery vectors. However, identifying peptides ideal safety features is difficult owing to the variations in amino acid sequences. Here, a holistic program based on computer modeling single‐cell RNA sequencing (scRNA‐seq) used identify peptides. Stage one of this consists sequential screening process for candidates assembly ability; stage two cell subtype‐level analysis that screens high vivo...