A5087695394- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Acupuncture Treatment Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Healthcare and Venom Research
- Computational Drug Discovery Methods
- Cancer Treatment and Pharmacology
- Cancer therapeutics and mechanisms
- Traditional Chinese Medicine Studies
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Immune cells in cancer
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
Wuhan University
2016-2025
Renmin Hospital of Wuhan University
2016-2025
Ruijin Hospital
2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Guangdong Academy of Medical Sciences
2020-2023
Southern Medical University
2020-2023
Guangdong Provincial People's Hospital
2020-2023
Xinjiang Medical University
2021-2023
Liaoning University of Traditional Chinese Medicine
2011-2023
Low-grade endometrial stromal sarcoma (LG-ESS) is a rare tumor that lacks prognostic prediction model. Our study aimed to develop nomogram predict overall survival of LG-ESS patients.A total 1172 patients confirmed have between 1988 and 2015 were selected from the Surveillance, Epidemiology End Results (SEER) database. They further divided into training cohort validation cohort. The Akaike information criterion was used select variables for nomogram. discrimination calibration evaluated...
Abstract Heart failure creates a leading public health burden worldwide and cardiac fibrosis is hallmark of pathological remodeling which was found in HF patients. In this study, we detected the expression 9 candidate miRNAs plasma exosome samples from 31 patients, level miR‐21, miR‐425 miR‐744 altered. The downregulation also angiotensin II treated fibroblasts. Through functional identified that reduction relates to overexpression collagen 1 α‐SMA, result fibrogenesis Conversely, or...
Abstract Objective: Triple-negative breast cancer (TNBC) involves higher rates of recurrence and distant metastasis. The present study sought to characterize the risk factors for metastasis TNBC. Methods: Surveillance, Epidemiology, End Results (SEER) database was exploited enroll patients diagnosed with TNBC from 2010 2015. eligible were dichotomized into locoregional at time diagnosis. Patients’ demographics tumor features, treatment evaluated identify primary categorical variables...
Background SMARCA4, the essential ATPase subunit of SWI/SNF chromatin remodeling complex, regulates transcription through control structure and is increasingly thought to play significant roles in human cancers. This study aims explore potential role SMARCA4 with a view providing insights on pathologic mechanisms implicated here. Methods The different tumors were explored based Cancer Genome Atlas (TCGA), Genotype-tissue expression (GTEx), Tumor Immune Estimation Resource (TIMER), Gene Set...
Immune infiltration of tumors has been increasingly accepted as a prognostic factor in colon cancer. Here, we aim to develop novel immune signature, based on estimated landscape from tumor transcriptomes, predict the overall survival patients with The compositions 22 cell subtypes three microarray datasets were characterized CIBERSORT deconvolution algorithm. A immunoscore (PIS) model for prediction was established by using least absolute shrinkage and selection operator (LASSO) penalized...
To verify that miR-490-5p could influence hepatocellular carcinoma (HCC) cells' proliferation, invasion, cycle, and apoptosis by targeting BUB1.Quantitative real time-PCR (QRT-PCR) was used to determine the expression. Immunohistochemistry, qRT-PCR, Western blot were employed detect BUB1 transforming growth factor-beta (TGFβ/Smad) signaling-related proteins expression in hepatic tissues cells. The luciferase assay confirm relationship between BUB1. Cell Counting Kit-8, colony formation,...
Abstract Objectives The value of adjuvant radiotherapy for triple‐negative breast cancer (TNBC) has been controversial recently. This study aims to clarify the influence on survival TNBC patients after surgery based a large population analysis. Methods Surveillance, Epidemiology, and End Results (SEER) database was exploited select eligible from 2010 2014. categorical variables were examined by chi‐square tests. Breast cancer‐specific (BCSS) overall (OS) compared among who received or not...
Abstract Alternative polyadenylation (APA) is emerging as a major mechanism of posttranscriptional regulation. APA can impact the development and progression cancer, suggesting that genetic determinants might play an important role in regulating cancer risk. Here, we depicted pan-cancer atlas human quantitative trait loci (apaQTL), containing approximately 0.7 million apaQTLs across 32 types. Systematic multiomics analyses indicated could contribute to regulation by altering poly(A) motifs,...
Background The predictive efficacy of current biomarker immune checkpoint inhibitors (ICIs) is not sufficient. This study investigated the causality between radiomic biomarkers and immunotherapy response status in patients with stage IB–IV non-small cell lung cancer (NSCLC), including its biological context for ICIs treatment prediction. Methods CT images from 319 pretreatment NSCLC receiving January 2015 November 2021 were retrospectively collected composed a discovery (n=214), independent...
<title>Abstract</title> Whereas the role of OR7E47P in NSCLC is not clear, we explored impact on prognosis patients and possible mechanisms through bioinformatics experi-mental approaches. OR7E47P, underexpressed tumor tissues, associated with better enhanced immune benefits. Localization analyses showed may func-tions as a cytoplasmic processing pseudogene, regulating ROBO2 expression via OR7E47P/miR-183-5p/ROBO2 pathway at post-transcriptional level. Single-cell re-vealed that reduces...
It has been recognized that alpha-fetoprotein (AFP), as an oncofetal antigen, is re-expressed in large amounts adult tumor cells and serves clinically useful purposes tumor-marker assays. However, its biological activities are still undefined. In the present study, ability of AFP to stimulate tumor-cell growth was observed by vitro experimental system. Mouse ascites cancer derived from hepatoma-22(H-22) or Ehrlich carcinoma(EAC) were extracted intraperitoneally cultured RPMI 1640 medium...
Radiation-induced lung injury (RILI) is the main complication of radiotherapy for thoracic malignancies. Since naringenin, a potent immune-modulator, has been found to relieve bleomycin-induced fibrosis by restoring balance disordered cytokines, we sought determine whether naringenin would mitigate RILI and investigate underlying mechanism. Animals received fractionated irradiation in area induce RILI. Enzyme-linked immunosorbent assay MILLIPLEX assays were used serum bronchoalveolar lavage...
The present study aims to investigate the efficacy and mechanisms of peroxisome proliferator-activated receptor γ coactivator 1-α agonist, as adjuvant programmed death-1 (PD-1) blockade in hyporesponsive lung cancer cells-derived vivo tumor model, using bezafibrate.Mouse Lewis carcinoma (LLC) xenograft models were established treated with death-ligand 1 (PD-L1) monoclonal antibodies or without bezafibrate. Tumors peripheral blood mice harvested quality, quantity, function well energetic...
Abstract Circulating tumor cells (CTCs) provide a new approach for auxiliary diagnosis, therapeutic effect evaluation, and prognosis prediction cancer patients. The epithelial cell adhesion molecule (EpCAM)-based separation method (CellSearch) showed good clinical use in multiple types of cancer. Nevertheless, some non-small lung (NSCLC) have lower expression EpCAM are less frequently detected by CellSearch. Here, we present highly sensitive immunomagnetic to capture CTCs based on two...
Abstract Long non‐coding RNA s (lnc s) have emerged as important regulators of cancer, including colorectal cancer ( CRC ). The exact expression pattern long intergenic noncoding 00312 LINC 00312) in and its mechanisms action not been reported. Here, we found that is underexpressed tissues cell lines. Functional experiments suggested suppresses growth, migration invasion cells vitro attenuates tumour proliferation metastasis vivo. Mechanistically, was to regulate the malignancy by binding...
Background: Mainstream application of cancer immunotherapy is hampered by the low response rate most patients. A novel immunotherapeutic target or a biomarker predicting to needs be developed. Guanylate-binding protein 1 (GBP1) an interferon (IFN)-inducible guanosine triphosphatases (GTPases) involving inflammation and infection. However, immunological effects GBP1 in pan-cancer patients are still obscure. Methods: Using large-scale public data, we delineated landscape across 33 types. The...
The chemotherapeutic agent doxorubicin (DOX) is limited by its cardiotoxicity, posing challenges in application for non-small cell lung cancer (NSCLC). This study aims to explore the efficacy of polydopamine/Au nanoparticles loaded with DOX chemotherapy and photothermal therapy NSCLC achieve enhanced reduced toxicity.