A5062737889- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Economic and Financial Impacts of Cancer
- Ferroptosis and cancer prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Infrared Thermography in Medicine
- S100 Proteins and Annexins
- Nitric Oxide and Endothelin Effects
- Pectus Deformity Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Environmental and Sediment Control
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac tumors and thrombi
- Medical Imaging and Pathology Studies
Charité - Universitätsmedizin Berlin
2021-2024
Humboldt-Universität zu Berlin
2024
Third Affiliated Hospital of Harbin Medical University
2024
Harbin Medical University
2024
Hainan Medical College Hospital
2023
Guangdong Academy of Medical Sciences
2019-2022
Southern Medical University
2020-2022
Guangdong Provincial People's Hospital
2019-2022
South China University of Technology
2020-2022
Jiangxi Provincial Cancer Hospital
2022
Abstract Objectives To develop and validate a preoperative CT-based nomogram combined with radiomic clinical–radiological signatures to distinguish preinvasive lesions from pulmonary invasive lesions. Methods This was retrospective, diagnostic study conducted August 1, 2018, May 2020, at three centers. Patients solitary nodule were enrolled in the GDPH center divided into two groups (7:3) randomly: development ( n = 149) internal validation 54). The SYSMH ZSLC Center formed an external...
ObjectivesThis study aims to develop and evaluate preoperative CT-based peritumoral tumoral radiomic features predict tumor spread through air space (STAS) status in clinical stage I lung adenocarcinoma (LUAD).Materials methodsFrom June 2018 December 2019, a retrospective diagnostic investigation was done. Patients with pathologically confirmed STAS (N = 256) were eventually enrolled. The development cohort consisted of 191 patients (74.6%) chosen randomly 7:3 ratio, whereas the validation...
Background The predictive efficacy of current biomarker immune checkpoint inhibitors (ICIs) is not sufficient. This study investigated the causality between radiomic biomarkers and immunotherapy response status in patients with stage IB–IV non-small cell lung cancer (NSCLC), including its biological context for ICIs treatment prediction. Methods CT images from 319 pretreatment NSCLC receiving January 2015 November 2021 were retrospectively collected composed a discovery (n=214), independent...
The KEAP1-NFE2L2 (Kelch-like ECH-associated protein 1 (KEAP1)-Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2)) mutations are associated with resistance to chemotherapy or immunotherapy in non-small cell lung cancer (NSCLC). Conversely, it has been reported that NFE2L2 potentiate improved clinical outcome immunotherapy. However, therapeutic benefits for patients KEAP1/NFE2L2 remain unclear. purpose of this study was investigate the association between and NSCLC prognosis, explore whether...
BackgroundThe efficacy and safety of neoadjuvant treatment over surgery alone that chemoradiotherapy (NCRT) chemotherapy (NCT) in resectable esophageal carcinoma remains inconclusive. This study (NewEC) used global data to comprehensively evaluate these comparisons provide a preferable strategy for patient subsets.MethodsThis included meta-analysis randomized controlled trials (RCTs) identified from inception May 2019 PubMed, EMBASE, the Cochrane Central Register Controlled Trials,...
Oncolytic viruses are of growing importance in cancer therapeutics since they combine direct oncolytic effect and the stimulation antitumor immunity. Emerging evidences showed that function is dependent on immune response tumor microenvironment, modulation immunity could influence their efficacy. Here we combined interleukin 10 (IL-10) adenovirus Ad-hTERT to treat lung explored underlying mechanism under combination therapy. Lewis carcinoma (LLC) B16F10 tumor-bearing immunocompetent C57BL/6...
Pectus excavatum (PE) is one of the most common chest wall defects. Accurate assessment PE deformities critical for effective surgical intervention. Index-based evaluations have become standard objectively estimating PE, however, these indexes cannot represent whole information CT images and may associated with significant error due to individual differences. To overcome limitations, this paper developed a computer-aided diagnosis (CAD) system based on convolutional neural network (CNN)...
Glucagon‐like peptide‐1 (GLP‐1) regulates glycemic excursions by augmenting insulin production and inhibiting glucagon secretion. Liraglutide, a long‐acting GLP‐1 analog, can improve control for treating type 2 diabetes prevent neutrophil extravasation in inflammation. Here, we explored the role of liraglutide development therapy murine lung liver cancers. In this study, substantially decreased circulating extracellular trap (NET) markers myeloperoxidase, elastase, dsDNA Lewis cancer (LLC)...
The current study aims to identify the dysregulated pathway involved in carcinogenesis and essential survival-related genes among this early stage of lung adenocarcinoma (LUAD). Data from Cancer Genome Atlas (TCGA) including 526 tumor tissues LUAD 59 healthy were analyzed gain differentially expressed (DEGs). Gene ontology (GO) analysis was conducted with DAVID, while Kyoto Encyclopedia Genes Genomes (KEGG) DEGs performed, followed by gene set enrichment (GSEA) methods. Survival implemented...
A polymeric nanocarrier with a cascade of magnetic and TAT targeting enhanced the therapeutic efficacy alectinib towards ALK-positive lung cancer.
e21551 Background: Molecular characterization studies revealed recurrent KEAP1/ NFE2L2 alterations in non-small cell lung cancer (NSCLC). Previous have confirmed that KEAP1/NFE2L2 mutations are a poor prognostic factor for chemotherapy patients with NSCLC. Nevertheless, it is unclear whether (MUT) of liquid biopsy can predict the efficacy immunotherapy Methods: Two independent cohorts (the OAK and POPLAR study cohort) data from approximately 853 advanced NSCLC were used to analyze effect on...
Abstract Purpose: Autophagy has a critical involvement in the initiation and progression of various cancers, including colorectal cancer (CRC). The feasibility using autophagy-related genes as prognostic tools for CRC patients is yet to be determined. Methods: We gathered RNA sequencing data clinical details (CRC) from TCGA our training set used GSE39582 dataset GEO database validation. Autophagy-related (ARGs) were obtained Human Database. Using R limma package, we identified differentially...
Pleural invasion (PI) is considered to be an adverse prognostic factor in non-small cell lung cancer (NSCLC). However, the roles of PI pathologic (p)T3-4N0M0 NSCLC remain controversial. Therefore, this study aimed evaluate predictive value patients with pT3-4N0M0 NSCLC.
The robust performance of machine learning techniques provides good application prospects for neuroimaging, not only breaking the limitations human eye recognition, but also improving generalization ability image features. By introducing and neuroimaging into field acupuncture, " acupuncture-point-disease" target advantage can be more objectively visually exploited, making it efficient clinical use. synthesizing relevant literature, author takes multidisciplinary intersection as a starting...
Background Owing to the cytotoxic effect, it is challenging for clinicians decide whether post-operative adjuvant therapy appropriate a non-small cell lung cancer (NSCLC) patient. Radiomics has proven its promising ability in predicting survival but research on actionable model, particularly supporting decision of therapy, limited. Methods Pre-operative contrast-enhanced CT images 123 NSCLC cases were collected, including 76, 13, 16, and 18 from R01 AMC cohorts The Cancer Imaging Archive...
e14087 Background: Immune-related adverse events (irAEs) have been shown to be associated with the efficacy of immune checkpoint inhibitors in patients advanced cancer, but reported effect sizes varied greatly previous trials. We did a meta-analysis assess and further explored correlation irAEs cancer. Methods: systematically searched database inception January, 2019 for randomized trials inhibitor cancer that had available data overall survival (OS) progression-free (PFS), irAEs. calculated...
Because of the many important anatomical structures located closely together at very small distances, mediastinal surgery has been traditionally demanding and challenging within thoracic surgery. With their great variability, masses in anterior, middle or posterior compartment result surgical indications with different principle focuses. The technical opportunities robotic assistance can thereby most effectively support requirement precision for all oncological aspects. Anterior operations...
Long non-coding RNAs (lncRNAs) participate in the regulation of immune response and carcinogenesis, shaping tumor microenvironment, which could be utilized construction prognostic signatures for non-small cell lung cancer (NSCLC) as supplements. Data patients with stage I-III NSCLC was downloaded from online databases. The least absolute shrinkage selection operator used to construct a lncRNA-based model. Differences microenvironments pathways were explored high-risk low-risk groups,...
A patient with pulmonary MALT lymphoma who was admitted to the hospital due fever underwent complete resection and final diagnosis by minimally invasive VATS surgery.Central Picture legend: CT image of a 57-year-old male lung lesion 27 x 29 50 mm in LLL.
e20037 Background: In recent years, there has been a better understanding of ways to use DNA damage and repair (DDR) mechanisms improve overall sensitivity and/or overcome resistance traditional treatments. The DDR network is quite complex highly dynamic with as many 450 proteins integral the repair. current study identify key dysregulated genes its related pathways especially in early progression lung adenocarcinoma. Methods: TCGA dataset adenocarcinoma (LUAD) including 59 healthy tissues...
Background: The current study aims to identify the key dysregulated genes and its related pathways in early progression of lung adenocarcinoma (LUAD). Methods: TCGA dataset LUAD including 59 healthy tissues 517 tumor were utilized detect differentially expressed mRNAs lncRNAs. Gene ontology (GO) analysis was conducted with DAVID, while Kyoto Encyclopedia Genes Genomes (KEGG) pathway performed using gene set enrichment (GSEA) methods. Findings: 41 lncRNAs 2,047 screened out as they LUAD....