This paper proposes a two-layer path-planning method, where an optimized artificial potential field (APF) method and improved dynamic window approach (DWA) are used at the global local layer, respectively. enables robot to plan better path under multi-obstacle environment while avoiding moving obstacles effectively. For part of planning, new repulsive is proposed based on APF method. The length smoothness taken as fitness functions particle swarm optimization (PSO) obtain obstacle influence...

e -p r o f mesenchymal to epithelial phenotype and reduced tumor size following combination losartan cisplatin treatment.Conclusions: Combination treatment attenuates the EMT pathway enhances cytotoxic effect of chemotherapy with in vitro vivo models NSCLC.This study suggests an important role for ASI therapy lung cancer.

To identify the 100 most cited papers in cataract surgery, we performed a comprehensive bibliometric analysis basing on literature search Thomson Reuters Web of Knowledge.The number citations, including total latest 5y citations and average citation per year (ACY), authorship, publication, major topics, journal country institution origin each paper were recorded then analyzed. Pearson's correlation was conducted to evaluate between published citations. The journal's impact factor (IF)...

The current study aims to identify the dysregulated pathway involved in carcinogenesis and essential survival-related genes among this early stage of lung adenocarcinoma (LUAD). Data from Cancer Genome Atlas (TCGA) including 526 tumor tissues LUAD 59 healthy were analyzed gain differentially expressed (DEGs). Gene ontology (GO) analysis was conducted with DAVID, while Kyoto Encyclopedia Genes Genomes (KEGG) DEGs performed, followed by gene set enrichment (GSEA) methods. Survival implemented...

Purpose. To identify the potential key genes and molecular pathways associated with keratoconus allergic disease. Methods. The pubmed2ensembl database was used to text mining (TMGs) collectively involved in GeneCodis program perform Gene Ontology (GO) biological process Kyoto Encyclopedia of Genes Genomes (KEGG) pathway enrichment analysis TMGs. protein-protein interaction (PPI) network TMGs established by STRING; significant gene modules hub PPI were further performed using Cytoscape...

Abstract Background To report a case in which silicone oil accidentally entered Berger’s space (BS) after vitrectomy and to explore the effective treatments possible etiological mechanisms. Case presentation A 68-year-old male underwent injection for treatment of retinal detachment (RD) right eye. Six months later, we noticed an unexpected lens-like round translucent substance located behind posterior lens capsule diagnosed it as BS filled by oil. Subsequently, conducted drainage second...

Abstract Myopia is a leading cause of visual impairment worldwide, whose pathogenesis remains poorly understood. We comprehensively performed phenome-wide Mendelian randomization analysis (MR-PheWAS) to explore causal factors and potential therapeutic targets for myopia in participants from the UK Biobank study. The revealed that 55 robust associations (1 disease, 2 employment, 3 cognitive functions, 4 sex-specific factor, mental health, 5 lifestyle environment, 10 sociodemographic, 12...

Abstract Background Ischemic stroke (IS) is a leading cause of death in elderly people. Previous studies on exploring the association between intraocular pressure (IOP), glaucoma and IS risk provided inconsistent results unclear elucidations. Methods Here, multiple genetic approaches were employed to investigate possible causality these traits. First, we performed traditional bidirectional mendelian randomization (MR) study explore causal relationship IOP, IS. Second, SNPs selected as...

Background: The normal tension glaucoma (NTG) has limited drug options since current anti-glaucoma medications are mostly designed to decrease intraocular pressure (IOP). emerging generative artificial intelligence (GAI) may provide an unprecedented approach for its repurposing research. Methods:First, we iteratively interactivated with ChatGPT using 10 independent queries. Each query consists of two prompts, which asked offer 20 candidates (DRCs) NTG. same process was employed find DRCs...

Abstract The traditional human-based fruit packing method is inefficient and costly. In response to the requirement of multiple fruits automatically in present market, a multiclass system based on computer vision designed. Firstly, image acquisition module captures images passes them recognition module, which converts RGB space HSV color extracts H S components. Secondly, by using morphological process target areas, class, size position are calculated. Finally, control manipulator grasps...

The track cleaning vehicle plays an important role in the and maintenance of modern tramway. To better monitor working conditions it eliminate occurrence accidents, a remote monitoring system is designed. Various types sensors are installed on to collect information data transmitted Tencent Cloud Database. software based QT helps administrators vehicle, providing warnings safety tips guarantee normal operation by acquiring from experimental results show that can remotely system, which...

Abstract Objectives Diabetic retinopathy (DR) is the leading cause of visual loss in working-age adults worldwide. Cheese a widely consumed dairy product, and cheese intake has various health benefiting effects. This study aimed to use Mendelian randomization (MR) investigate impact consumption on DR. Methods The genome-wide association (GWAS) summary statistic generated from 451486 European descent was introduced identify valid instrumental variables (IVs) for intake. As outcomes, GWAS data...

AIM: To present the multi-omics landscape of cutaneous melanoma (CM) and uveal (UM) from The Cancer Genome Atlas (TCGA). METHODS: differentially expressed genes (DEGs) between CM UM were found integrated into a gene ontology enrichment analysis. Besides, miRNAs also identified. We compared methylation level with identified methylated regions to integrate DEGs display relationship expression DNA methylation. transcription factors (TFs) RESULTS: Though had more mutational burden than UM, they...

Blood-based B-cell activating factor (BAFF), growth differentiation factor-15 (GDF-15) and osteopontin (OPN) have been identified to be promising biomarkers for the metastases of uveal melanoma (UM). This study intended assess their kinetics evaluate significance as a three-marker panel. A group 36 UM patients with 137 without were included in study. Their plasma OPN levels measured by ELISA; serum BAFF GDF-15 determined Luminex MAGPIX system. Receiver operating characteristic (ROC) analysis...

Abstract Supported by the Zhuhai Collaborative Innovation Project, we develop a Road-Rail Precision Cleaning Vehicle for rail of first modern tramway based on Tram Wave system in China, which has been built City. Development scheme overall mechanical structure, electrical control and condition monitoring man-machine interface realized. We also designed target recognition algorithm OpenCV to actuators like solenoid valve, electromagnetic clutch air pressure regulating valve so on.

This paper develops a double closed-loop control strategy aiming at the trajectory tracking of wheeled mobile robots (WMRs) under skidding and slipping. Firstly, kinematic model slipping dynamic are proposed to describe WMR slipping, respectively. Then, an anti-skidding controller based on Lyapunov direct anti-slipping terminal sliding mode (TSMC) separately devoted. All them consist effectively solve same time. In addition, radial basis function neural network (RBFNN) is employed estimate...

This study proposes a time-optimal control method for wheeled inverted pendulum (WIP) vehicle under specified paths. Firstly, the given path is described with parametric form, and kinematic model, velocity constraint acceleration are all parameterized same parameter as geometric path. Meanwhile, stabilization of body also formulated through coupling relationship to take underactuated characteristic into full consideration. Next, trajectory constructed by sequence minimum maximum trajectories...

In this paper, the author proposes to use PG-LSTM (physics guided long short-term memory neural network) model circuit and mechanical structure of micro-loudspeaker improve accuracy diaphragm displacement prediction. Compared with conventional physical model, takes into account influence temperature on loudspeaker system, reduces prediction errors caused by system nonlinear factors when input signal amplitude is large. The experimental results show that mean-squared-error...