A5031042628- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Corneal Surgery and Treatments
- Cytomegalovirus and herpesvirus research
- Neurological Disorders and Treatments
- Nuclear Receptors and Signaling
- Retinal and Macular Surgery
- Metabolism, Diabetes, and Cancer
- GDF15 and Related Biomarkers
- Carbon and Quantum Dots Applications
- Ophthalmology and Eye Disorders
- Genetic Associations and Epidemiology
- Thallium and Germanium Studies
- Pleural and Pulmonary Diseases
- Extraction and Separation Processes
- Actinomycetales infections and treatment
- Pancreatitis Pathology and Treatment
- Selenium in Biological Systems
- Personality Disorders and Psychopathology
- Occupational and environmental lung diseases
- Cerebral Venous Sinus Thrombosis
Shanghai Eye Disease Prevention & Treatment Center
2024
Anhui Medical University
2013-2024
First Affiliated Hospital of Anhui Medical University
2013-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Second Affiliated Hospital of Soochow University
2024
Soochow University
2018-2024
First Affiliated Hospital of Soochow University
2018-2024
Shanghai First People's Hospital
2022-2024
Guangzhou University
2023
Shanghai Jiao Tong University
2022-2023
BackgroundGlaucoma, particularly primary angle closure glaucoma (PACG), is a leading cause of global blindness. Nearly half all people with PACG are Chinese descent. Population-level screening has generally not been found to be cost-effective in high-income countries; however, this assessment rarely done low-income or middle-income countries. We aimed assess the cost-effectiveness and cost-utility population-level China.MethodsWe developed decision-analytic Markov models for separate...
Background: Glaucoma is a leading cause of irreversible blindness. Remodeling the scleral extracellular matrix (ECM) plays an important role in development glaucoma. The aim this study was to identify key genes and pathways for ECM remodeling sclera glaucoma by bioinformatics analysis explore potential therapeutic agents management. Methods: Genes associated with glaucoma, were detected using text mining tool pubmed2ensembl, assigned Gene Ontology (GO) biological process terms Kyoto...
Scleral extracellular matrix (ECM) remodeling is thought to play a critical role in the pathogenesis of glaucoma. Mechanical strain induced by elevated intraocular pressure can promote myofibroblast differentiation fibroblasts and result scleral ECM remodeling; however, underlying mechanism remains poorly understood. Yes-associated protein (YAP) mechanosensory key downstream transcriptional effector Hippo signaling pathway. Here, we investigated YAP mechanical strain-induced transformation...
Background This study assessed the quality distribution of non-mydriatic fundus photographs (NMFPs) in real-world glaucoma screening and analysed its influencing factors. Methods cross-sectional was conducted primary healthcare centres Yinzhou District, China, from 17 March to 3 December 2021. The bilateral NMFPs by Digital Reading Department Eye Hospital Wenzhou Medical University. Generalised estimating equations logistic regression models identified factors affecting image quality....
Chronic hypoxia-induced pulmonary vascular remodeling is a feature of chronic obstructive disease (COPD). Our previous reports indicate that neuron-derived orphan receptor 1 (NOR1) promoted smooth muscle cell proliferation in vitro. But it remains unclear whether NOR1 participated into COPD patients.For this study, we collected peripheral lung tissues 26 male patients with or without hypoxemia. We detected the all tissues. Primary human arterial cells were also cultured vitro and stimulated...
Abstract Direct comparison data on spatial patterns of visual field (VF) defects among primary angle-closure glaucoma (PACG), high-tension (HTG) and normal-tension (NTG) are not available. We aimed to compare the intraocular asymmetry VF loss patients with PACG, NTG HTG across different severity levels. A total 162 eyes 114 111 74 148 102 were included. categorized into 3 stages (early, moderate, advanced), each hemifield was divided 5 regions according Glaucoma test (GHT). The mean...
Surfactant protein D (SP-D) is an innate immunity molecule in the alveoli. However, associations between genetic variants of SP-D and radiation pneumonitis (RP) have never been investigated.The Linkage disequilibrium tagSNPs were analyzed by using Haploview 4.1. Eight genotyped among 396 lung cancer patients who received thoracic therapy with follow-up time (median [P25, P75]: 11[6, 18]) improved multiplex ligation detection reaction (iMLDR). The clinical characteristics, tagSNP alleles,...
Purpose. To identify the potential key genes and molecular pathways associated with keratoconus allergic disease. Methods. The pubmed2ensembl database was used to text mining (TMGs) collectively involved in GeneCodis program perform Gene Ontology (GO) biological process Kyoto Encyclopedia of Genes Genomes (KEGG) pathway enrichment analysis TMGs. protein-protein interaction (PPI) network TMGs established by STRING; significant gene modules hub PPI were further performed using Cytoscape...
<title>Abstract</title> Objective To explore the application value of different respiratory intervention techniques in therapy refractory persistent air leakage (PAL)after pulmonary surgery. Method A retrospective study was conducted 12 patients with PAL after surgery who were successfully treated by endoscopy Department Respiratory and Critical Care Medicine Fourth Hospital Affiliated to Soochow University First from December 2019 January 2024. According typies techniques, we divided them...
Abstract Background Ischemic stroke (IS) is a leading cause of death in elderly people. Previous studies on exploring the association between intraocular pressure (IOP), glaucoma and IS risk provided inconsistent results unclear elucidations. Methods Here, multiple genetic approaches were employed to investigate possible causality these traits. First, we performed traditional bidirectional mendelian randomization (MR) study explore causal relationship IOP, IS. Second, SNPs selected as...
Pulmonary Nocardiosis (PN) and invasive pulmonary aspergillosis (IPA) are opportunistic infections with high mortality.Immunosuppressive status is a major risk factor for the development of PN IPA, but co-infection Nocardia Aspergillus relatively rare.
To explore the value of our protocol respiratory endoscopy intervention in treatment refractory persistent air leakage(PAL) after pulmonary surgery. A retrospective study was conducted 12 patients with PAL surgery who were successfully treated by Department Respiratory and Critical Care Medicine Fourth Hospital Affiliated to Soochow University First from December 2019 January 2024. 4 types included protocol; A: chest tube drainage combined negative pressure suction; B: medical thoracoscopy...
Abstract Background Variants in the GABRA2 gene, which encodes α2 subunit of γ‐aminobutyric acid A receptor, have been linked to a rare form developmental and epileptic encephalopathy (DEE) referred as DEE78. Only eight patients reported globally. This study presents clinical presentation genetic analysis Chinese family with child diagnosed DEE78, due novel variant. Methods Genetic diagnosis was performed using trio‐whole exome sequencing, followed by bioinformatics predictions...
Abstract Myopia is a leading cause of visual impairment worldwide, whose pathogenesis remains poorly understood. We comprehensively performed phenome-wide Mendelian randomization analysis (MR-PheWAS) to explore causal factors and potential therapeutic targets for myopia in participants from the UK Biobank study. The revealed that 55 robust associations (1 disease, 2 employment, 3 cognitive functions, 4 sex-specific factor, mental health, 5 lifestyle environment, 10 sociodemographic, 12...
Abstract During targeted treatment, oncogene-addicted tumor cells often evolve from an initial drug-sensitive state through a drug-tolerant persister bottleneck toward the ultimate emergence of drug-resistant clones. The molecular basis underlying this therapy-induced evolutionary trajectory has not yet been completely elucidated. Here, we employed multifaceted approach and implicated convergent role transcription factor Yin Yang 1 (YY1) in course diverse kinase inhibitors. Specifically,...
Batch and column leaching tests are used to study thallium's release migration behaviour evaluate its potential toxicity risks in soil. The results indicate that concentrations of Tl using TCLP SWLP much higher than the threshold, indicating a high risk thallium pollution Furthermore, intermittent rate by Ca2+ HCl reached maximum value, demonstrating easy Tl. After leaching, form soil has changed, ammonium sulfate increased extractability. Additionally, extensive application calcium promote...