A5108047622- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Pain Mechanisms and Treatments
- Intensive Care Unit Cognitive Disorders
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- Airway Management and Intubation Techniques
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac and Coronary Surgery Techniques
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Veterinary Pharmacology and Anesthesia
- Nausea and vomiting management
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Hemoglobin structure and function
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2025
West China Medical Center of Sichuan University
2000-2025
Dalian Medical University
2021-2025
First Affiliated Hospital of Dalian Medical University
2022-2025
Hainan University
2023-2025
Second Xiangya Hospital of Central South University
2025
Central South University
2020-2025
Hunan Institute of Mental Health
2025
The bispectral (BIS) index and 95% spectral edge frequency (SEF) of the electroencephalograph (EEG) have been used to study anesthetic sedative effects intravenously (IV) administered drugs.This prospective was designed evaluate effectiveness BIS SEF for assessing level propofol-induced sedation amnesia during regional anesthesia. Ten consenting adult patients undergoing surgery with anesthesia were propofol in increments 10-20 mg IV, every 5-10 min until they became unresponsive tactile...
The aim of the present study was to evaluate single and joint associations maternal prepregnancy body mass index (BMI) gestational weight gain (GWG) with pregnancy outcomes in Tianjin, China.Between June 2009 May 2011, health care records 33,973 pregnant women were collected their children measured for birth length. independent BMI GWG based on Institute Medicine (IOM) guidelines risks neonatal examined by using Logistic Regression.After adjustment all confounding factors, positively...
Abstract Immune-related adverse events (irAEs), caused by anti-PD-1/PD-L1 antibodies, can lead to fulminant and even fatal consequences thus require early detection aggressive management. However, a comprehensive approach identify biomarkers of irAE is lacking. Here, we utilize strategy that combines pharmacovigilance data omics data, evaluate associations between multi-omics factors reporting odds ratio across different cancer types. We bivariate regression model LCP1 ADPGK accurately...
Histone deacetylase 6 (HDAC6) primarily catalyzes the removal of acetyl group from side chain acetylated lysine residues in cytoplasmic proteins such as α-tubulin and HSP90. HDAC6 is involved multiple disease-relevant pathways. Based on proteolysis targeting chimera strategy, we previously developed first degrader by tethering a pan-HDAC inhibitor with cereblon (CRBN) E3 ubiquitin ligase ligand. We herein report our new generation multifunctional degraders selective Nexturastat A CRBN ligand...
Abstract Ferroptosis, a newly defined mode of regulated cell death caused by unbalanced lipid redox metabolism, is implicated in various tissue injuries and tumorigenesis. However, the role ferroptosis stem cells has not yet been investigated. Glutathione peroxidase 4 (GPX4) critical suppressor peroxidation ferroptosis. Here, we study function GPX4 hematopoietic progenitor (HSPCs) mice with Gpx4 deficiency system. We find that deletion solely system no significant effect on number HSPCs...
Ciprofol is a propofol analogue with improved pharmacokinetic properties. A multi-centre, non-inferiority trial was conducted to compare the deep sedation properties of ciprofol and margin 8% in patients undergoing gastroscopy colonoscopy. In total, 289 were randomly allocated for surgery (259 colonoscopy 30 gastroscopy) at 1:1 ratio be given intravenous injections (0.4 mg/kg) or (1.5 mg/kg). The primary outcome success rate defined as completion no need an alternative sedative >5 top up...
Doxorubicin is an effective chemotherapy drug for treating various types of cancer. However, lethal cardiotoxicity severely limits its clinical use. Recent evidence has indicated that aberrant activation the cytosolic DNA-sensing cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-STING (stimulator interferon genes) pathway plays a critical role in cardiovascular destruction. Here, we investigate involvement this mechanism doxorubicin-induced (DIC). Mice were treated with...
The bispectral (BIS) index and 95% spectral edge frequency (SEF) of the electroencephalograph (EEG) have been used to study anesthetic sedative effects intravenously (IV) administered drugs.This prospective was designed evaluate effectiveness BIS SEF for assessing level propofol-induced sedation amnesia during regional anesthesia. Ten consenting adult patients undergoing surgery with anesthesia were propofol in increments 10-20 mg IV, every 5-10 min until they became unresponsive tactile...
The electroencephalogram (EEG) has been used to study the effects of anesthetic and analgesic drugs on central nervous system function. A prospective was designed evaluate accuracy various EEG parameters for assessing midazolam-induced sedation during regional anesthesia.Twenty-six consenting adult patients were administered 4.5-20 mg intravenous midazolam (in increments 0.5-1 bolus doses every 6-10 min) until they became unresponsive tactile stimulation (i.e., mild prodding or shaking)....
The low solubility of sevoflurane in blood suggests that this agent should enter and leave the body more rapidly than isoflurane. However, closeness isoflurane tissue/blood partition coefficients rates equilibration with elimination from tissues be similar. We tested both predictions, comparing nitrous oxide seven volunteers. measured rate at which alveolar (end-tidal) (FA) concentration increased toward an inspired (FI) 65%–70%, then concurrent rise FA mixed expired concentrations (FM)...
The correlation between the potency of inhaled anesthetics and their solubility in a hydrophobic phase provides an opportunity to define better characteristics anesthetic site action. implies that act solvent used has properties representative true We sought characterize this more accurately by testing for provided best diverse group anesthetics. determined halothane, enflurane, cyclopropane, fluroxene, isoflurane, sevoflurane, desflurane benzene, olive oil, Intralipid, n-octanol, lecithin....
Background Metastasis, the spread and growth of tumor cells to distant organ sites, represents most devastating attribute plays a major role in morbidity mortality cancer. Inflammation is crucial for malignant transformation survival. Thus, blocking inflammation expected serve as an effective cancer treatment. Among anti-inflammation therapies, chemokine modulation now beginning emerge from pipeline. CXC receptor-4 (CXCR4) its ligand stromal cell-derived factor-1 (CXCL12) interaction...
Chimeric apoptotic bodies promote M2 polarization of macrophages to modulate inflammation.
Parkinson's disease (PD) is a common neurodegenerative disorder, for which there are no effective disease-modifying therapies. The transcription factor ATF4 (activating 4) induced by multiple PD-relevant stressors, such as endoplasmic reticulum stress and oxidative damage. may exert either protective or deleterious effects on cell survival, depending the paradigm. However, role of in pathogenesis PD has not been explored. We find that levels increased neuromelanin-positive neurons substantia...