A5075061733- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Hydrogels: synthesis, properties, applications
- Advanced Photocatalysis Techniques
- Phagocytosis and Immune Regulation
- Dental materials and restorations
- Protease and Inhibitor Mechanisms
- Pharmacological Effects of Natural Compounds
- Alkaloids: synthesis and pharmacology
- Oral microbiology and periodontitis research
- Micro and Nano Robotics
- Advanced biosensing and bioanalysis techniques
- Proteoglycans and glycosaminoglycans research
- Electrospun Nanofibers in Biomedical Applications
- Dental Implant Techniques and Outcomes
- Advancements in Transdermal Drug Delivery
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Dendrimers and Hyperbranched Polymers
Northwest Institute For Non-Ferrous Metal Research
2024
Xi'an Jiaotong University
2017-2023
China XD Group (China)
2017-2020
Microbial infection has been considered as one of the most critical challenges in bioengineering applications especially tissue regeneration, which engenders severe threat to public health. Herein, a hydrogel performing properties rapid self-healing, on-demand antibiosis and controlled cargo release was fabricated by simple assembly Fe complex cross-linker hyaluronic acid gel network. This is able locally degrade Fe3+ kill bacteria needed because hyaluronidase excreted surrounding bacteria,...
Multiresponsive adjuvant nanoparticles (RMmAGL) are fabricated to perform tumor-specific photothermal therapy while regulating the behavior of tumor-associated immune cells for primary tumor eradication and metastasis inhibition. Core-satellite-like RMmAGL have a core mannose-functionalized mesoporous silica loaded with TLR7 agonist imiquimod (R837@MSN-mannose) connected via hydrazone bonds satellites glutamine (Glu)- lysine (Lys)-comodified gold (AuNPs-Glu/Lys). During therapy, acidic...
Chimeric apoptotic bodies promote M2 polarization of macrophages to modulate inflammation.
An injectable hydrogel was developed using mesoporous silica nanoparticles to co-deliver miR222 and aspirin, osteogenesis enhanced by stimulating innervation.
Abstract Development of new therapeutic scaffolds to selectively destruct tumors under gentle conditions meanwhile promoting adipose tissue formation would be a promising strategy for clinical treatment breast cancer. Herein, stimuli‐responsive scaffold composed polyacrylic acid‐ g ‐polylactic acid (PAA‐ ‐PLLA) modified graphene oxide (GO) with cleavable bond in between (GO‐PAA‐ ‐PLLA), gambogic (GA), and polycaprolactone (PCL) is fabricated then preseeded on adipose‐derived stem cells...
Estrogen deficiency is one of the most frequent causes osteoporosis in postmenopausal women. Under chronic inflammatory conditions caused by estrogen deficiency, activated T cells contribute to elevated levels proinflammatory cytokines, impaired osteogenic differentiation capabilities bone marrow mesenchymal stem (BMMSCs), and disturbed regulatory cell (Treg)/Th17 balance. However, therapeutic strategies that re-establish immune homeostasis this disorder have not been well developed. Here,...
Multiple amino acid (glutamine and lysine)-modified gold nanoparticles a with pH-switchable zwitterionic surface were fabricated through coordination bonds using ferrous iron (Fe2+) as bridge ions, which are able to spontaneously selectively assemble in tumor cells for accurate therapy combining enzyme-triggered photothermal H2O2-dependent catalytic medicine. These showed electric neutrality at pH 7.4 (hematological system) prevent endocytosis of normal cells, could be positively charged 6.8...
Modular microparticles induce antigen-specific immune tolerance by inducing apoptosis and promoting T reg differentiation.
Abstract Implantation of biomedical devices accompanying infections has caused severe problems to public health that require feasible solutions. In this study, a simple approach is reported fabricate antimicrobial and antifouling dual‐functional coating. This coating consists substrate‐independent layer‐by‐layer (LBL) film formed by poly (diallyldimethylammonium) (PDDA) (styrenesulfonate) (PSS), where parts PSS PDDA are physically substituted hetero‐bifunctional polyethylene glycol (PEG)...
A dual responsive hydrogel based on MSNs was fabricated to offer a strategy for sequential tumor therapy and tissue regeneration.
Herein, we reveal a double emulsion method combining the sol–gel to prepare poly(lactic-<italic>co</italic>-glycolic acid) microspheres with different porous structures for sequential release of two types biomolecules.
Herein, a rambutan-like nanocomplex (PDA-SNO-GA-HA-DOX, PSGHD for short) was designed to enable effective and accurate tumor therapy. The consists of an S-nitrosothiol-functionalized polydopamine (PDA-SNO) core gambogic acid-derivatized hyaluronic acid (HA-GA) shell with doxorubicin (DOX) as the cargo. Due HA section, can be rapidly selectively internalized by cells instead healthy in 12 h co-incubation. After that, is able gradually release both DOX (agent chemotherapy) GA enhancing thermal...
Tumor recurrence caused by metastasis is a major cause of death for patients.
The combination of therapeutic and diagnostic functions in a single platform has aroused great interest due to the more optimal synergistic effects that can be obtained as compared any theranostic approach alone.
Tissue fibrosis caused by implantation of tissue engineering scaffolds is an urgent problem in clinical research.
Berberine (BB) has demonstrated significant inhibitory effects on tumorigenesis and progression. However, its clinical application is hindered by challenges such as low bioavailability due to limited cell membrane permeability, nontargeted accumulation away from solid tumors, increased toxicity associated with intravenous administration. To overcome these challenges, a lipophilic salt-forming strategy was employed enhance lipophilicity, thereby promoting permeability targetability for tumor...