A5063336626- Plant Molecular Biology Research
- Nanoplatforms for cancer theranostics
- Algebraic Geometry and Number Theory
- Plant Reproductive Biology
- Advanced Algebra and Geometry
- Analytic Number Theory Research
- Electrospun Nanofibers in Biomedical Applications
- Natural Fiber Reinforced Composites
- Block Copolymer Self-Assembly
- Nanoparticle-Based Drug Delivery
- Aluminum Alloys Composites Properties
- Flame retardant materials and properties
- Conducting polymers and applications
- Phase Change Materials Research
- Advanced Sensor and Energy Harvesting Materials
- Advanced Nanomaterials in Catalysis
- Copper-based nanomaterials and applications
- Plant Parasitism and Resistance
- Geometric Analysis and Curvature Flows
- Geometry and complex manifolds
- 3D Printing in Biomedical Research
- Fatigue and fracture mechanics
- Liquid Crystal Research Advancements
- Plant nutrient uptake and metabolism
- Homotopy and Cohomology in Algebraic Topology
Xi'an Jiaotong University
2021-2025
Zhejiang Lab
2025
Center for Life Sciences
2025
Sichuan University
2021-2023
Chinese Academy of Sciences
2012-2022
Center for Excellence in Molecular Plant Sciences
2006-2022
University of Chinese Academy of Sciences
2022
First Affiliated Hospital of Xiamen University
2021-2022
Fujian Medical University
2021
Kyushu University
2002-2020
Zygomorphic flowers, with bilateral (dorsoventral) symmetry, are considered to have evolved several times independently in flowering plants. In Antirrhinum majus , floral dorsoventral symmetry depends on the activity of two TCP-box genes, CYCLOIDEA ( CYC ) and DICHOTOMA DICH ). To examine whether same molecular mechanism asymmetry operates distantly related Rosid clade eudicots, which asymmetric flowers thought independently, we investigated function a homologue LjCYC2 papilionoid legume,...
Floral zygomorphy (flowers with bilateral symmetry) has multiple origins and typically manifests two kinds of asymmetries, dorsoventral (DV) organ internal (IN) asymmetries in floral planes, respectively, revealing the underlying key regulators plant genomes that generate superimpose various mechanisms to build up complexity different forms during development. In this study, we investigate loci affecting these development pea (Pisum sativum L.). Two genes, LOBED STANDARD 1 (LST1) KEELED...
The existence of lattice strain between two different materials can be used to control the fine structural configuration in a hybrid colloidal nanostructure. Enabled by such, relative position change Au and CdX Au-CdX from symmetric an asymmetric is demonstrated, which further lead tuning plasmon-exciton coupling hydrogen photocatalytic performance. These results provide new insight into plasmon enhanced mechanisms potential catalysts for photoreduction reactions.
Abscisic acid (ABA) regulates plant development and adaptation to environmental conditions. Although the ABA biosynthesis pathway in plants has been thoroughly elucidated, how biosynthetic genes are regulated at molecular level during is less well understood. Here, we show that tomato (Solanum lycopersicum) zinc finger transcription factor SlZFP2 involved regulation of fruit development. Overexpression resulted multiple phenotypic changes, including more branches, early flowering, delayed...
Inflammatory response plays a critical role in myocardial infarction (MI) repair. The neutrophil apoptosis and subsequent macrophage ingestion can result inflammation resolution initiate regeneration, while the therapeutic strategy that simulates enhances this natural process has not been established. Here, we constructed engineered apoptotic bodies (eNABs) to simulate apoptosis, which regulated enhanced MI eNABs were fabricated by combining body membrane excellent inflammation-tropism...
Tumorigenic environments, especially aberrantly overexpressed oncogenic microRNAs, play a critical role in various activities of tumor progression. However, developing strategies to effectively utilize and manipulate these microRNAs for therapy is still challenge. To address this challenge, spherical nucleic acids (SNAs) consisting gold nanoparticles the core antisense oligonucleotides as shell are fabricated. Hybridized oligonucleotide DNA sequence which doxorubicin conjugated (DNA-DOX)....
In this study, we show that combined use of Imatinib (IM) and arsenic sulfide [As 4 S (AS)] exerts more profound therapeutic effects in a BCR / ABL -positive mouse model chronic myeloid leukemia (CML) than either drug as single agent. A systematic analysis dynamic changes the proteome, phosphoproteome, transcriptome K562 cells after AS and/or IM treatment was performed to address mechanisms underlying synergy. Our data indicate promotes activities unfolded protein reaction (UPR)...
Tumor microenvironment (TME), as the "soil" of tumor growth and metastasis, exhibits significant differences from normal physiological conditions. However, how to manipulate distinctions achieve accurate therapy primary metastatic tumors is still a challenge. Herein, an innovative nanoreactor (AH@MBTF) developed utilize apparent (copper concentration H2O2 level) between cells eliminate based on H2O2-dependent photothermal-chemodynamic suppress through copper complexation. This constructed...
Abstract The normal operation of organelles is critical for tumor growth and metastasis. Herein, an intelligent nanoplatform (BMA EF ) fabricated to perform on‐demand destruction mitochondria golgi apparatus, which also generates the enhanced photothermal‐immunotherapy, resulting in effective inhibition primary metastasis tumor. BMA has a core mesoporous silica nanoparticles loaded with brefeldin A (BM), connected ethylenebis(oxyethylenenitrilo)tetraacetic acid (EGTA) folic co‐modified gold...
We report a general well-controlled synthetic strategy to achieve meticulous control of metallic shell growth at the single monolayer level with versatile core nanoparticles, thus facilitating investigation their scope for numerous applications. The central component this is introduce an intermediate phase in transfer reaction finely tune process. Two different typed nanoparticles distinct functionality and surface chemistry, including semiconductor are chosen demonstrate versatility our...
Abstract Background Heat-shock transcription factor 4 (HSF4) mutations are associated with autosomal dominant lamellar cataract and Marner cataract. Disruptions of the Hsf4 gene cause lens defects in mice, indicating a requirement for HSF4 fiber cell differentiation during development. However, neither relationship between crystallins nor detailed mechanism maintenance transparency by is fully understood. Results In an attempt to determine how underlying biomedical physiological mechanisms...
Abstract The management of oral squamous cell carcinoma (OSCC) poses significant challenges, leading to organ impairment and ineffective treatment deep‐seated tumors, adversely affecting patient prognosis. A cascade nanoreactor that integrates photodynamic therapy (PDT) chemodynamic (CDT) for comprehensive multimodal OSCC is introduced. Utilizing iron oxide mesoporous silica, the FMMSH drug delivery system, encapsulating photosensitizer prodrug δ‐aminolevulinic acid (δ‐ALA), developed....
Abstract Herein, an engineered nanocomposite (FZS HC ) was constructed containing zinc‐based nanozyme(ZS), Hemin and Ca 2+ ions with further surface modification of phospholipid folic acid (FA) for primary metastatic breast cancer therapy. During therapy, the FZS initially accumulated in tumor tissues through enhanced permeability retention effectand FA receptor‐mediated tumor‐targeting delivery. After that, dissociated to free loaded ZS acidic environment lysosome. The resulting then...