A5100620151- Extracellular vesicles in disease
- Aquaculture disease management and microbiota
- Orthodontics and Dentofacial Orthopedics
- Pain Mechanisms and Treatments
- Aquaculture Nutrition and Growth
- Dental Radiography and Imaging
- MicroRNA in disease regulation
- Botulinum Toxin and Related Neurological Disorders
- Diabetes Treatment and Management
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Temporomandibular Joint Disorders
- Immune cells in cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacology and Obesity Treatment
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Muscle Physiology and Disorders
- Diabetic Foot Ulcer Assessment and Management
- Phagocytosis and Immune Regulation
- Diabetes and associated disorders
- Biochemical effects in animals
- Thyroid Disorders and Treatments
- Hemodynamic Monitoring and Therapy
- Cardiovascular Health and Risk Factors
Second Hospital of Shanxi Medical University
2023-2025
Shanxi Medical University
2023-2025
Zunyi Medical University
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Guangdong Ocean University
2024
Air Force Medical University
2016-2024
Chengdu University
2023-2024
Jilin Agricultural University
2023-2024
China Medical University
2023-2024
As the major interface between body and external environment, skin is liable to various injuries. Skin injuries often lead severe disability, exploration of promising therapeutic strategies great importance. Exogenous mesenchymal stem cell (MSC)-based therapy a potential strategy due apparent effects, while underlying mechanism still elusive. Interestingly, we observed extensive apoptosis exogenous bone marrow cells (BMMSCs) in short time after transplantation mouse wound healing models....
Extracellular vesicles (EVs) derived from living cells play important roles in donor cell-induced recipient tissue regeneration. Although numerous studies have found that undergo apoptosis after implantation an ischemic-hypoxic environment, the played by EVs released apoptotic are largely unknown. In this study, we obtained (apoVs) human deciduous pulp stem and explored their effects on dental regeneration process. Our work showed apoVs were ingested endothelial (ECs) elevated expression of...
Skin serves as the major interface between external environment and body which is liable to many kinds of injuries. Mesenchymal stem cell (MSC) therapy has been widely used became a promising strategy. Pre-treatment with chemical agents, hypoxia or gene modifications can partially protect MSCs against injury, pre-treated show improved differentiation, homing capacity, survival paracrine effects regard attenuating injury. The aim this study was investigate whether exosomes from educated...
Inflammatory response plays a critical role in myocardial infarction (MI) repair. The neutrophil apoptosis and subsequent macrophage ingestion can result inflammation resolution initiate regeneration, while the therapeutic strategy that simulates enhances this natural process has not been established. Here, we constructed engineered apoptotic bodies (eNABs) to simulate apoptosis, which regulated enhanced MI eNABs were fabricated by combining body membrane excellent inflammation-tropism...
Background: Embryonic stem cells (ES) have a great potential for cell-based therapies in regenerative medicine. However, the ethical and safety issues limit its clinical application. ES-derived extracellular vesicles (ES-EVs) been reported suppress cellular senescence. Mesenchymal (MSCs) are widely used cell therapy. In this study, we investigated beneficial effects of ES-EVs on aging MSCs to further enhancing their therapeutic effects. Methods:In vitro, explored rejuvenating senescent by...
Estrogen deficiency is one of the most frequent causes osteoporosis in postmenopausal women. Under chronic inflammatory conditions caused by estrogen deficiency, activated T cells contribute to elevated levels proinflammatory cytokines, impaired osteogenic differentiation capabilities bone marrow mesenchymal stem (BMMSCs), and disturbed regulatory cell (Treg)/Th17 balance. However, therapeutic strategies that re-establish immune homeostasis this disorder have not been well developed. Here,...
Thyroid disorders are associated with various dietary factors and nutritional elements. The aim of this study was to investigate the relationships between vitamin E intake prevalence thyroid dysfunction antibody positivity using data from National Health Nutrition Examination Survey (NHANES) database.
The aim of the present study was to use sudomotor function test, Sudoscan, as a screening method for evaluation asymptomatic diabetic distal symmetric polyneuropathy in Chinese type 2 diabetes patients. As result, more attention could be paid those patients who easily neglected and underdiagnosed everyday clinic.A total 394 were enrolled tested symptoms clinical signs neuropathy using Neurological Symptom Score, Neuropathy Disability vibration perception threshold. Sudoscan carried out,...
BACKGROUND Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) plays a crucial role in metabolizing and detoxifying endogenous exogenous substances. However, its contribution to the progression of liver damage remains unclear. AIM To determine mechanism UGT1A1 progression. METHODS We investigated relationship between expression injury through clinical research. Additionally, impact on was analyzed mouse model study. RESULTS Patients with gene mutations showed varying degrees damage,...
Abstract Radiation enteritis is the most common complication of pelvic radiotherapy, but there no effective prevention or treatment drug. Apoptotic T cells and their products play an important role in regulating inflammation maintaining physiological immune homeostasis. Here it shown that systemically infused cell‐derived apoptotic extracellular vesicles (ApoEVs) can target mice irradiated intestines alleviate radiation enteritis. Mechanistically, elevates synthesis intestinal 2′3′ cyclic...
<title>Abstract</title> <bold>Background </bold>Osteosarcoma has been a common bone malignancy occurring in children and adolescents. Attributing to high tumor heterogeneity, none specific breakthrough received targeted gene therapy for osteosarcoma, although it’s still of great potential immunotherapy clinical application. In the study, 5 GEO profiles containing transcriptome information 109 osteosarcoma samples, single cell sequencing data composed 6 cases as well 43 local hospital tissue...
ABSTRACT Gastric cancer (GC) prognosis is significantly influenced by intratumoral microbiomes, which modulate host–immune interactions. This study analyzed data from the The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to identify immune genes associated with GC conducted prognostic subtypes. patients were classified into two distinct phenotypes C1 C2 based on non-negative matrix factorization consensus clusters. Phenotype exhibited a better characteristics,...
Type 2 diabetes mellitus (T2DM) is more prevalent in aging populations. Older adults with have higher rates of macro and micro vascular complications. Our study assessed whether age an independent factor for both large small nerve dysfunctions Chinese patients T2DM. This cross-sectional involved a total 950 type (mean age: 60.01±12.30 years). Diabetic peripheral neuropathy (DPN) was according to clinical symptoms physical examinations by using symptom score (NSS), the disability (NDS),...
Abstract Background Embryonic stem cell-derived extracellular vesicles (ESC-EVs) possess therapeutic potential for a variety of diseases and are considered as an alternative ES cells. Acute kidney injury (AKI) is common acute severe disease in clinical practice, which seriously threatens human life health. However, the roles mechanisms ESC-EVs on AKI remain unclear. Methods In this study, we evaluated effects physiological repair pathological using murine ischemia-reperfusion injury-induced...
Type H vessels couple angiogenesis with osteogenesis, while sympathetic cues regulate vascular and skeletal function. The crosstalk between nerves type in bone remains unclear. Here, we first identify close spatial connections bone, particularly metaphysis. Sympathoexcitation, mimicked by isoproterenol (ISO) injection, reduces mass. Conversely, beta-2-adrenergic receptor (ADRB2) deficiency maintains mass the physiological condition. In vitro experiments reveal indirect modulation of via...
Arsenic (As) and copper (Cu) are two common contaminants in the environment. When organisms exposed to As or/ Cu large quantities or for sustained periods, oxidative stress is induced, adversely affecting kidney function. However, molecular mechanisms involved Cu-induced nephrotoxicity remain elusive. In this experiment, wild-type C57BL/6 Nrf2-knockout mice (n = 24 each) were arsenic trioxide chloride alone combination. Our research findings indicate that exposure can activate Nrf2...