A5100419201- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Insect Resistance and Genetics
- Periodontal Regeneration and Treatments
- Insect-Plant Interactions and Control
- Maternal Mental Health During Pregnancy and Postpartum
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Genomics and Phylogenetic Studies
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
- Microbial Metabolic Engineering and Bioproduction
- Tissue Engineering and Regenerative Medicine
- Fungal Biology and Applications
- Plant Molecular Biology Research
- Breastfeeding Practices and Influences
- Maternal and Perinatal Health Interventions
- Plant Reproductive Biology
- Cholesterol and Lipid Metabolism
- Insect Pest Control Strategies
- bioluminescence and chemiluminescence research
- Plant Gene Expression Analysis
- Monoclonal and Polyclonal Antibodies Research
Shenzhen Maternity and Child Healthcare Hospital
2019-2024
Washington University in St. Louis
2021-2024
China Medical University
2020-2024
Shenyang Center for Disease Control and Prevention
2021-2024
Chongqing University
2024
Wuhan University
2024
Shandong University of Traditional Chinese Medicine
2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Northeast Forestry University
2012-2024
North Sichuan Medical University
2024
Coronavirus disease 2019 (COVID-19), which emerged in Wuhan, China December 2019, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has become a major global public h...
Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying mechanisms are not fully understood, especially paradox between low survival rate of transplanted cells and beneficial effects generated by these cells. Herein, in myocardial infarction (MI) model, we found that MSCs released apoptotic bodies (ABs) to enhance angiogenesis improve cardiac functional reclovery via regulating macroautophagy/autophagy...
Extracellular vesicles (EVs) derived from living cells play important roles in donor cell-induced recipient tissue regeneration. Although numerous studies have found that undergo apoptosis after implantation an ischemic-hypoxic environment, the played by EVs released apoptotic are largely unknown. In this study, we obtained (apoVs) human deciduous pulp stem and explored their effects on dental regeneration process. Our work showed apoVs were ingested endothelial (ECs) elevated expression of...
Chimeric apoptotic bodies promote M2 polarization of macrophages to modulate inflammation.
Abstract Objectives Pulp regeneration brings big challenges for clinicians, and vascularization is considered as its determining factor. We previously accomplished pulp with autologous stem cells from deciduous teeth (SHED) aggregates implantation in teenager patients, however, the underlying mechanism needs to be clarified regenerating adults. Serving an important effector of mesenchymal (MSCs), exosomes have been reported promote angiogenesis tissue effectively. Here, we aimed investigate...
Inflammation plays a crucial role in triggering regeneration, while inadequate or chronic inflammation hinders the regenerative process, resulting refractory wounds. Inspired by ideal regeneration mode lower vertebrates and human oral mucosa, realigning dysregulated to heightened acute response provides promising option for wound therapy. Neutrophils play important roles initiation resolution. Here, hybrid biomaterial is used stimulate transiently inflammatory responses precise tempospatial...
The fall armyworm, Spodoptera frugiperda (Noctuidae: Lepidoptera), is a wide-reaching notorious insect pest of important cereal crops, which has developed resistance to multiple classes insecticides. It invaded the Sichuan Province China in 2019. In this study, we performed monitoring insecticides for 11 field-collected populations from Sichuan, and all were susceptible emamectin benzoate chlorpyrifos. variations level indoxacarb (resistance ratio (RR), 9.23-45.53-fold), spinetoram (RR,...
Next-generation sequencing (NGS) technologies have generated enormous amounts of shotgun read data, and assembly the reads can be challenging, especially for organisms without template sequences. We study power genome comparison based on data using three alignment-free sequence statistics, D(2), D(*)(2) D(s)(2), both theoretically by simulations. Theoretical formulas detecting relationship between two sequences related through a common motif model are derived. It is shown that outperform...
Regenerative endodontic procedures (REPs) are a new option for the treatment of dental pulp or periapical diseases in permanent teeth with open apices. Histologically, tissues formed root canal after REPs mainly cementum- bone-like mineralised tissues, but not real dentine-pulp complex. Therefore, how to promote complex regeneration and improve clinical effects has become prominent research topic. Stem cells from apical papilla (SCAP) derived that can differentiate into primary odontoblasts...
Abstract Background Most studies have showed that maternal depression is associated with pregnancy complications. However, there were limited evidences in Chinese population. We examined the associations of antenatal symptoms outcomes, especially for low birth weight. Methods A total 1377 singleton pregnant women recruited from Nanshan Maternity & Child Healthcare Hospital Shenzhen this prospective cohort study. Depression assessed by Edinburgh postnatal scale (EPDS) questionnaire second...
Harnessing developmental processes for tissue engineering represents a promising yet challenging approach to regenerative medicine. Tooth avulsion is among the most serious traumatic dental injuries, whereas functional tooth regeneration remains uncertain. Here, we established strategy using decellularized matrix (DTM) combined with human pulp stem cell (hDPSC) aggregates simulate an odontogenesis-related microenvironment. The bioengineered teeth reconstructed by this regenerated...
Estrogen deficiency is one of the most frequent causes osteoporosis in postmenopausal women. Under chronic inflammatory conditions caused by estrogen deficiency, activated T cells contribute to elevated levels proinflammatory cytokines, impaired osteogenic differentiation capabilities bone marrow mesenchymal stem (BMMSCs), and disturbed regulatory cell (Treg)/Th17 balance. However, therapeutic strategies that re-establish immune homeostasis this disorder have not been well developed. Here,...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still epidemic around the world. manipulation of SARS-CoV-2 restricted to biosafety level 3 laboratories (BSL-3). In this study, we developed a ΔN-GFP-HiBiT replicon delivery particles (RDPs) encoding dual reporter gene, GFP-HiBiT, capable producing both GFP signal and luciferase activities. Through optimal selection GFP-HiBiT demonstrated superior stability convenience for antiviral evaluation. Additionally, established RDP...
Salidroside, a valuable phenylethanoid glycoside, is obtained from plants belonging to the Rhodiola genus, known for its diverse biological properties. At present, salidroside still far large-scale industrial production due lower titer and higher process cost. In this study, we have first time increased by enhancing UDP-glucose supply in situ. We constructed an vivo regeneration system that works conjunction with transferase innovatively improve availability. And coculture was formed order...
Ly-6A is a murine antigen which implicated in lymphocyte activation and may be involved of hematopoietic stem cells. Antibody cross-linking studies antisense experiments have suggested that coactivation molecule. To better understand the function Ly-6A, we used gene targeting to produce null mice are healthy normal numbers percentages lineages. However, T lymphocytes from Ly-6A–deficient animals proliferate at significantly higher rate response antigens mitogens than wild-type littermates....
Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II detoxification enzymes involved in glycosylation of lipophilic endobiotics and xenobiotics, including phytoalexins. Nicotine, one the most abundant secondary plant metabolites tobacco, is highly toxic to herbivorous insects. Plant-herbivore competition impetus for evolution large superfamilies UGTs other enzymes. However, UGT functions green peach aphid (Myzus persicae) adaptation unknown. In this study, we show that...
Zinc oxide nanoparticles (ZnONPs) are one of the most important nanomaterials that widely used in food, cosmetic and medical industries. Humans often exposed to ZnONPs via inhalation, they may reach brain where neurotoxic effects could occur systemic distribution. However, mechanisms underlying how produce remain unclear. In this study, we aimed investigate novel mechanism involved ZnONPs-induced neurotoxicity.We demonstrated for first time pulmonary exposure by intratracheal instillation...
Abstract Background Reconstruction of complex critical-size defects (CSD) in the craniofacial region is a major challenge, and soft tissue regeneration crucial determining therapeutic outcomes CSD. Stem cells from apical papilla (SCAP) are neural crest-derived mesenchymal stem (MSCs) that homologous to represent promising source for regeneration. Exosomes, which contain compound bioactive compounds, key factors cell paracrine action. However, roles exosomes derived SCAP (SCAP-Exo) not fully...